Effects of calcitriol on parathyroid function and on bone remodelling in secondary hyperparathyroidism

Nephrology Dialysis Transplantation

Volumn 18, Issue 4, 2003, Pages 743-749

  Falcão Pedrosa Costa, André ^a   Machado dos Reis, Luciene ^a   Custódio Ribeiro, Melani ^a   Affonso Moysés, Rosa Maria ^a   Jorgetti, Vanda ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bone biopsy; Calcitriol; Calcium; Histomorphometry; PTH; Secondary hyperparathyroidism

Indexed keywords

CALCIFEDIOL; CALCITRIOL; CALCIUM; CITRATE SODIUM; GLUCONATE CALCIUM; PARATHYROID HORMONE; PHOSPHORUS;

ADULT; ARTICLE; BONE EROSION; BONE REMODELING; BONE TURNOVER; CALCIUM METABOLISM; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CONTROLLED STUDY; DIALYSIS; DRUG RESPONSE; FEMALE; HUMAN; HYPOCALCEMIA; MALE; METABOLIC DISORDER; MORPHOMETRICS; OSSIFICATION; OSTEOID; PARATHYROID FUNCTION; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE METABOLISM; PRIORITY JOURNAL; SCHOOL CHILD; SECONDARY HYPERPARATHYROIDISM; VITAMIN D METABOLISM;

ADULT; BONE REMODELING; CALCITRIOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; HYPERPARATHYROIDISM, SECONDARY; INFUSIONS, INTRAVENOUS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; PARATHYROID GLANDS; PROBABILITY; PROGNOSIS; PROSPECTIVE STUDIES; RENAL DIALYSIS; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 0037386337     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/gfg017     Document Type: Article

References (27)

1. Goodman WG. Recent developments in the management of secondary hyperparathyroidism. Kidney Int 2001; 59: 1187-1201
2. Drüeke TB. Parathyroid gland hyperplasia in uremia. Kidney Int 2001; 59: 1182-1183
3. Slatopolsky EA, Weerts C, Thielan J, Horst R, Harter H. Marked suppression of secondary hyperparathyroidism by intravenous administration of 1,25-dihydroxycholecalciferol in uremic patients. J Clin Invest 1984; 74: 2136-2143
4. Rodriguez M, Caravaca F, Fernandea E et al. Parathyroid function as a determinant of the response to calcitriol treatment in hemodialysis patients. Kidney Int 1999; 56: 306-317
5. Cannella G, Bonucci E, Rolla D et al. Evidence of healing of secondary hyperparathyroidism in chronically hemodialyzed uremic patients treated with long-term intravenous calcitriol. Kidney Int 1994; 46: 1124-1132
6. Ramirez JA, Goodman WG, Gornbein J et al. Direct in vivo comparison of calcium-regulated parathyroid hormone secretion in normal volunteers and patients with secondary hyperparathyroidism. J Clin Endocrinol Metab 1993; 76: 1489-1494
7. Brown EM. Four parameter model of the sigmoidal relationship between parathyroid hormone release and extracellular calcium concentration in normal and abnormal parathyroid tissue. J Clin Endocrinol Metab 1983; 56: 572-581
8. Malluche HH, Faugere M-C. Methodology of mineralized bone histology. In: Malluche HH, Faugere M-C, eds. Atlas of Mineralized Bone Histology. Karger, Basel, Switzerland, 1986; 17-24
9. Dos Reis LM, Martins CT, Jorgetti V. Histochemical staining of bone aluminum: comparison of aluminon and acid solochrome azurine and their correlation with bone aluminum content. Rev Hosp Clin Fac Med S Paulo 1997; 52: 171-174
10. Parfitt AM, Drezner MK, Glorieux FH et al. Bone histomorphometry: standardization of nomenclature, symbols and units. J Bone Miner Res 1987; 6: 595-610
11. Jorgetti V, Ricco Soeiro NM, Mendes V et al. Aluminum-related osteodystrophy and desferrioxamine treatment: role of phosphorus. Nephrol Dial Transplant 1994; 9: 668-674
12. Ghazali A, Fardellone P, Pruna A et al. Is low plasma 25-(OH) vitamin D a major risk factor for hyperparathyroidism and Looser's zones independent of calcitriol? Kidney Int 1999; 55: 2169-2177
13. Salusky I, Goodman WG. Parathyroid gland function in secondary hyperparathyroidism. Pediatr Nephrol 1996; 10: 359-363
14. Gogusev J, Duchambon P, Hory B, Giovannini M, Sarfatie E, Drüeke TB. Depressed expression of calcium receptor in parathyroid gland tissue of patients with primary or secondary hyperparathyroidism. Kidney Int 1997; 51: 328-336
15. 2+ - sensing expression in parathyroid adenoma. Calcif Tissue Int 1999; 64: 271-272
16. Felsenfeld AJ, Rodriguez M, Dunlay R, Llach F. A comparison of parathyroid-gland function in hemodialysis patients with different forms of renal osteodystrophy. Nephrol Dial Transplant 1991; 6: 244-251
17. Ureña P, Bernard-Poenaru O, Cohen-Solal M, de Vernejoul MC. Plasma bone-specific alkaline phosphatase changes in hemodialysis patients treated by alfacalcidol. Clin Nephrol 2002; 57: 261-273
18. Delmez JA, Tindira C, Grooms P, Dusso A, Windus DW, Slatopolsky E. Parathyroid hormone suppression by intravenous 1,25-dihydroxyvitamin D. A role for increased sensitivity to calcium. J Clin Invest 1989; 83: 1349-1355
19. Dunlay R, Rodriguez M, Felsenfeld AJ, Llach F. Direct inhibitory effect of calcitriol on parathyroid function (sigmoidal curve) in dialysis. Kidney Int 1989; 36: 1093-1098
20. Malberti F, Surian M, Cosci P. Effect of chronic intravenous calcitriol on parathyroid function and set point of calcium in dialysis patients with refractory hyperparathyroidism. Nephrol Dial Transplant 1992; 7: 822-828
21. Ramirez JA, Goodman WG, Belin T, Gales B, Segre GV, Salusky IB. Calcitriol therapy and calcium-regulated PTH secretion in patients with secondary hyperparathyroidism. Am J Physiol (Endocrinol Metab) 1994; 267: E961-E967
22. Moysés RMA, Pereira RC, Dos Reis LM, Sabbaga E, Jorgetti V. Dynamic tests of parathyroid hormone secretion using hemodialysis and calcium infusion cannot be compared. Kidney Int 1999; 56: 659-665
23. 3 in fetal bone. Science 1997; 197: 1086-1088
24. Holtrop ME, Cox KA, Clark MB, Holick MF, Anast CS. 1,25-dihydroxycholecalciferol stimulates osteoclasts in rat bones in the absence of parathyroid hormone. Endocrinology 1981; 108: 2293-2301
25. Langub MC, Koszewski NJ, Turner HV et al. Bone resorption and mRNA expression of IL-6 and IL-6 receptor in patients with renal osteodystrophy. Kidney Int 1996; 50: 515-520
26. 2, a vitamin D analog with reduced bone resorbing activity in vitro. J Am Soc Nephrol 2000; 11: 1857-1864
27. Pahl M, Jara A, Bover J, Felsenfeld A. Studies in a hemodialysis patient indicating that calcitriol may have a direct suppressive effect on bone. Nephron 1995; 71: 218-223