Phase 1 trial of prevention of hydrocephalus after intraventricular hemorrhage in newborn infants by drainage, irrigation, and fibrinolytic therapy

Pediatrics

Volumn 111, Issue 4, 2003, Pages 759-765

  Whitelaw, Andrew ^a,d   Pople, Ian ^b   Cherian, Shobha ^a   Evans, David ^c   Thoresen, Marianne ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b FRENCHAY HOSPITAL   (United Kingdom)

^c SOUTHMEAD HOSPITAL   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Fibrinolysis; Hydrocephalus; Intraventricular hemorrhage; Irrigation; Newborn infant

Indexed keywords

CYTOKINE; FIBRINOLYTIC AGENT; TISSUE PLASMINOGEN ACTIVATOR;

ARTICLE; BRAIN HEMORRHAGE; BRAIN INJURY; CAUSE OF DEATH; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID DRAINAGE; CLINICAL ARTICLE; CLINICAL TRIAL; DISABILITY; EXTRACTION; FIBRINOLYTIC THERAPY; GESTATIONAL AGE; HUMAN; HYDROCEPHALUS; INFANT; INTRAVENOUS CATHETER; LAVAGE; NEWBORN; PHASE 1 CLINICAL TRIAL; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; SHUNTING; SURVIVAL RATE;

BRAIN DAMAGE, CHRONIC; CATHETERIZATION; CEREBRAL HEMORRHAGE; CEREBRAL VENTRICLES; DRAINAGE; ERYTHROCYTE TRANSFUSION; HUMANS; HYDROCEPHALUS; INFANT; INFANT, NEWBORN; IRRIGATION; MORBIDITY; PILOT PROJECTS; POSTOPERATIVE COMPLICATIONS; THROMBOLYTIC THERAPY; TREATMENT OUTCOME; VENTRICULOPERITONEAL SHUNT; VENTRICULOSTOMY;

EID: 0037386039     PISSN: 00314005     EISSN: None     Source Type: Journal    
DOI: 10.1542/peds.111.4.759     Document Type: Article

References (31)

1. Volpe, JJ. Neurology of the Newborn. 4th ed. Philadelphia, PA: Saunders; 2001:428-493
2. Murphy BP, Inder TE, Rooks V, et al. Posthemorrhagic ventricular dilatation in the premature infant: natural history and predictors of outcome. Arch Dis Child. 2002;87:F37-F41
3. Ventriculomegaly Trial Group. Randomised trial of early tapping in neonatal post-hemorrhagic ventricular dilatation. Arch Dis Child. 1990; 65:3-10
4. Kennedy CR, Ayers S, Campbell MJ, Elbourne D, Hope P, Johnson A. Randomized, controlled trial of acetazolamide and furosemide in post-hemorrhagic ventricular dilatation in infancy: follow-up at 1 year. Pediatrics. 2001;108:597-607
5. Whitelaw A, Mowinckel MC, Fellman V, Abildgaard U. Endogenous tissue plasminogen activator in neonatal cerebrospinal fluid. Eur J Pediatr. 1996;155:117-119
6. Whitelaw A, Mowinckel MC, Larsen M, Rokas E, Abildgaard U. Intraventricular streptokinase increases cerebrospinal D dimer in preterm infants with posthemorrhagic ventricular dilatation. Acta Paediatr. 1994;83:270-272
7. Whitelaw A, Mowinckel MC, Abildgaard U. Low levels of plasminogen in cerebrospinal fluid after intraventricular hemorrhage: a limiting factor for clot lysis? Acta Paediatr. 1995;84:933-936
8. Hansen A, Whitelaw A, Lapp C, Brugnara C. Cerebrospinal fluid plasminogen activator inhibitor-1: a prognostic factor in posthemorrhagic hydrocephalus. Acta Paediatr. 1997;86:995-998
9. Whitelaw A, Rivers RPA, Creighton L, Gaffney P. Low dose intraventricular fibrinolytic treatment to prevent posthemorrhagic hydrocephalus. Arch Dis Child. 1992;67:12-14
10. Whitelaw A, Saliba E, Fellman V, Mowinckel M-C, Acolet D, Marlow N. A phase 1 study of intraventricular recombinant tissue plasminogen activator for the treatment of posthemorrhagic hydrocephalus. Arch Dis Child. 1996;75:F20-F26
11. Hansen A, Volpe JJ, Goumnerova LC, Madsen JR. Intraventricular urokinase for the treatment of posthemorrhagic hydrocephalus. Pediatr Neurol. 1997;17:213-217
12. Luciano R, Velardi F, Romagnoli C, Papacci P, De Stafano V, Tortorolo G. Failure of fibrinolytic endoventricular treatment to prevent neonatal post-hemorrhagic hydrocephalus. Child Nerv Syst. 1997;13:73-76
13. Larroche JC. Posthemorrhagic hydrocephalus in infancy. Biol Neonate. 1972;20:287-299
14. Beck LS, Chen TL, Amman AJ, et al. Accelerated healing of ulcer wounds in the rabbit ear by recombinant human transforming growth factor β-1. Growth Factors. 1990;2:273-282
15. Ignotz RA, Massague J. Transforming growth factor beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem. 1986;261:4337-4345
16. Roberts AB, Sporn MB, Assoian RK, et al. Transforming growth factor type β rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A. 1986;83:4167-4171
17. Massague J, Boyd FT, Andres JL, Chefetz S. Mediators of TGF-β action: TGF-β receptors and TGF-β-binding proteoglycans. Ann N Y Acad Sci. 1990;593:59-72
18. Kitazawa K, Tada T. Elevation of transforming growth factor β-1 level in cerebrospinal fluid of patients with communicating hydrocephalus after subarachnoid hemorrhage. Stroke. 1994;25:1400-1404
19. Tada T, Kanaji M, Kobayashi S. Induction of communicating hydrocephalus in mice by intrathecal injection of human recombinant transforming growth factor β-1. J Neuroimmunol. 1994;50:153-158
20. Whitelaw A, Christie S, Pople I. Transforming growth factor β-1: a possible signal molecule for post-hemorrhagic hydrocephalus? Pediatr Res. 1999;46:576-580
21. Kaiser A, Whitelaw A. Cerebrospinal fluid pressure during posthemorrhagic ventricular dilatation in newborn infants. Arch Dis Child. 1985;60:920-923
22. Savman K, Nilsson UA, Blennow M, Kjellmer I, Whitelaw A. Non-protein-bound iron is elevated in cerebrospinal fluid from preterm infants with posthemorrhagic ventricular dilatation. Pediatr Res. 2001;49:208-212
23. Savman K, Blennow M, Hagberg H, Tarkowski E, Thoresen M, Whitelaw A. Pro-inflammatory cytokines in cerebrospinal fluid after intraventricular hemorrhage in preterm infants. Pediatr Res. 2001;49:365A
24. Findlay JM, Weir BKA, Stollery DE. Lysis of intraventricular hematoma with tissue plasminogen activator. Case report. J Neurosurg. 1991;74:455-464
25. Mayfrank L, Lippitz B, Groth M, et al. Effect of recombinant tissue plasminogen activator on clot lysis and ventricular dilatation in the treatment of severe intraventricular hemorrhage. Acta Neurochir. 1993;122:32-38
26. Shen PH, Matsuoka Y, Kawajiri K, et al. Treatment of intraventricular hemorrhage using urokinase. Neurol Med Chir (Tokyo). 1990;30:329-330
27. Rohde V, Schaller C, Hassler WE. Intraventricular recombinant tissue plasminogen activator for lysis of intraventricular hemorrhage. J Neurol Neurosurg Psychiatry. 1995;58:447-451
28. Levene M. Measurement of the growth of the lateral ventricle in pre-term infants with real-time ultrasound. Arch Dis Child. 1981;56:900-904
29. Griffiths R. The Abilities of Babies. Amersham, United Kingdom: Association for Research in Child Development; 1954
30. Amiel-Tison C, Stewart AL. Follow-up studies in the first five years of life: a pervasive assessment of neurological function. Arch Dis Child. 1989;64:496-502
31. De Vries LS, Liem KD, van Dijk K, et al. Early versus late treatment of posthaemorrhagic ventricular dilatation: results of a retrospective study from five neonatal intensive care units in the Netherlands. Acta Paediatr. 2002;91:212-217