Partial restoration of cytokine profile despite reconstitution of cytomegalovirus-specific cell-mediated immunity in human immunodeficiency virus-infected patients during highly active antiretroviral treatment

Scandinavian Journal of Immunology

Volumn 57, Issue 4, 2003, Pages 375-383

  Alfonzo, M ^a   Blanc, D ^b   Troadec, C ^b   Eliaszewicz, M ^b   Gonzalez G ^b   Scott Algara, D ^a  

^a INSTITUT PASTEUR   (France)

^b SAINT JOSEPH HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2;

ADULT; ARTICLE; CELL COUNT; CELL SPECIFICITY; CELLULAR IMMUNITY; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CYTOMEGALOVIRUS; FOLLOW UP; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; ANTIGENS, VIRAL; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4-POSITIVE T-LYMPHOCYTES; CELL DIVISION; COHORT STUDIES; CYTOKINES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HIV INFECTIONS; HIV-1; HUMANS; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0037385259     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2003.01234.x     Document Type: Article

References (41)

1. Lane HC, Depper JM, Greene WC, Whalen G, Waldmann TA, Fauci AS. Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. Evidence for a selective defect in soluble antigen recognition. N Engl J Med 1985;313:79-84.
2. Fauci AS. Host factors in the pathogenesis of HIV disease. Antibiot Chemother 1996;48:4-12.
3. Graziosi C, Soudeyns H, Rizzardi GP, Bart PA, Chapuis A, Pantaleo G. Immunopathogenesis of HIV infection. AIDS Res Hum Retroviruses 1998;14 (Suppl. 2):S135-42.
4. Masur H, Whircup SM, Cartwright C, Polis M, Nussenblatt R. Advances in the management of AIDS-related cytomegalovirus retinitis. Ann Intern Med 1996;125:126-36.
5. Reusser P, Riddell SR, Meyers JD, Greenberg PD. Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: pattern of recovery and correlation with cytomegalovirus infection and disease. Blood 1991;78:1373-80.
6. Walter EA, Greenberg PD, Gilbert MJ et al. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med 1995;333:1038-44.
7. Kalams SA, Walker BD. The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J Exp Med 1998;188:2199-204.
8. + T cell counts and recurrent retinitis. J Infect Dis 2001;183:1285-9.
9. + T-cell responses to CMV in HIV-1-infected subjects. Virology 2001;279:459-70.
10. Sester M, Sester U, Gartner B et al. Levels of virus-specific CD4 T cells correlate with cytomegalovirus control and predict virus-induced disease after renal transplantation. Transplantation 2001;71:1287-94.
11. Whitcup SM, Fortin E, Nussenblatt RB, Polis MA, Muccioli C, Belfort Jr R. Therapeutic effect of combination antiretroviral therapy on cytomegalovirus retinitis. JAMA 1997;277:1519-20.
12. Tural C, Romeu J, Sirera G et al. Long-lasting remission of cytomegalovirus retinitis without maintenance therapy in human immunodeficiency virus-infected patients. J Infect Dis 1998;177:1080-3.
13. Weinberg A, Wohl DA, Barrett RJ, van der Horst C. Inconsistent reconstitution of cytomegalovirus-specific cell-mediated immunity in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy. J Infect Dis 2001;184:707-12.
14. Johnson SC, Benson CA, Johnson DW, Weinberg A. Recurrences of cytomegalovirus retinitis in a human immunodeficiency virus-infected patient, despite potent antiretroviral therapy and apparent immune reconstitution. Clin Infect Dis 2001;32:815-9.
15. Hsieh SM, Pan SC, Hung CC, Tsai HC, Chen MY, Chang SC. Association between cytomegalovirus-specific reactivity of T cell subsets and development of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. J Infect Dis 2001;184:1386-91.
16. Gerna G, Piccinini G, Genini E et al. Declining levels of rescued lymphoproliferative response to human cytomegalovirus (HCMV) in AIDS patients with or without HCMV disease following long-term HAART. J Acquir Immune Defic Syndr 2001;28:320-31.
17. Polic B, Hengel H, Krmpotic A et al. Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection. J Exp Med 1998;188:1047-54.
18. Steffens HP, Kurz S, Holtappels R, Reddehase MJ. Preemptive CD8 T-cell immunotherapy of acute cytomegalovirus infection prevents lethal disease, limits the burden of latent viral genomes, and reduces the risk of virus recurrence. J Virol 1998;72:1797-804.
19. Riddell SR, Watanabe KS, Goodrich JM, Li CR, Agha ME, Greenberg PD. Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 1992;257:238-41.
20. Spiegel HM, Ogg GS, DeFalcon E et al. Human immunodeficiency virus type 1- and cytomegalovirus-specific cytotoxic T lymphocytes can persist at high frequency for prolonged periods in the absence of circulating peripheral CD4(+) T cells. J Virol 2000;74:1018-22.
21. Tay-Kearney ML, Enger C, Semba RD, Royal III W, Dunn JP, Jabs DA. T cell subsets and cytomegalovirus retinids in human immunodeficiency virus-infected patients. J Infect Dis 1997;176:790-4.
22. + counts and prevalence of cytomegalovirus retinitis and human immunodeficiency virus-related noninfectious retinal vasculopathy in patients with acquired immunodeficiency syndrome. Am J Ophthalmol 1993;115:575-82.
23. + T cell subsets as a strong adaptive immune response to cytomegalovirus. J infect Dis 2001;184:256-67.
24. Dunn HS, Haney DJ, Ghanekar SA, Stepick-Biek P, Lewis DB, Maecker HT. Dynamics of CD4 and CD8 T cell responses to cytomegalovirus in healthy human donors. J Infect Dis 2002;186:15-22.
25. Mitsuyasu RT. The potential role of interleukin-2 in HIV. AIDS 2001;15 (Suppl. 2):S22-7.
26. Pantaleo G, Fauci AS. Immunopathogenesis of HIV infection. Annu Rev Microbiol 1996;50:825-54.
27. Clerici M, Shearer GM. Cellular immunity and a type 1 cytokine profile in protection against HIV infection and progression to AIDS. Res Immunol 1994;145:635-41.
28. + T cells to a TH2 phenotype and its possible relationship to the onset of AIDS. Res Immunol 1994;145:643-5.
29. Lathbury LJ, Allan JE, Shellam GR, Scalzo AA. Effect of host genotype in determining the relative roles of natural killer cells and T cells in mediating protection against murine cytomegalovirus infection. J Gen Virol 1996;77:2605-13.
30. Jonjic S, Pavic I, Polic B, Crnkovic I, Lucin P, Koszinowski UH. Antibodies are not essential for the resolution of primary cytomegalovirus infection but limit dissemination of recurrent virus. J Exp Med 1994;179:1713-7.
31. De Maeyer E, De Maeyer-Guignard J. Interferon-gamma. Curr Opin Immunol 1992;4:321-6.
32. + cell numbers and clinical staging. J Clin Invest 1989;84:1892-9.
33. Schulick RD, Clerici M, Dolan MJ, Shearer GM. Limiting dilution analysis of interleukin-2-producing T cells responsive to recall and alloantigens in human immunodeficiency virus-infected and uninfected individuals. Eur J Immunol 1993;23:412-7.
34. Clerici M, Hakim FT, Venzon DJ et al. Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals. J Clin Invest 1993;91:759-65.
35. + T lymphocytes by inhibiting interleukin 2 mRNA. Proc Natl Acad Sci USA 1990;87:2379-83.
36. + T lymphoid (H9) cell line. AIDS Res Hum Retroviruses 1995;11:31-40.
37. Tortorella D, Gewurz BE, Furman MH, Schust DJ, Ploegh HL. Viral subversion of the immune system. Annu Rev Immunol 2000;18:861-926.
38. Zanghellini F, Boppana SB, Emery VC, Griffiths PD, Pass RF. Asymptomatic primary cytomegalovirus infection: virologic and immunologic features. J Infect Dis 1999;180:702-7.
39. + T cells of human immunodeficiency virus-infected patients after 9 months of highly active antiretroviral therapy. J Infect Dis 1999;180:1057-63.
40. Macdonald JC, Torriani FJ, Morse LS, Karavellas MP, Reed JB, Freeman WR. Lack of reactivation of cytomegalovirus (CMV) retinitis after stopping CMV maintenance therapy in AIDS patients with sustained elevations in CD4 T cells in response to highly active antiretroviral therapy. J Infect Dis 1998;177:1182-7.
41. Whitcup SM, Fortin E, Lindblad AS et al. Discontinuation of anti-cytomegalovirus therapy in patients with HIV infection and cytomegalovirus retinitis. JAMA 1999;282:1633-7.