Effect of chondroitinase ABC on purulent sputum from cystic fibrosis and other patients

Pediatric Research

Volumn 53, Issue 4, 2003, Pages 619-627

  Khatri, Ismat A ^a   Bhaskar, K Ramakrishnan ^b   Lamont, J Thomas ^b   Sajjan, S Umadevi ^a   Ho, Catherine K Y ^a   Forstner, Janet ^a  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHONDROITIN ABC LYASE; CHONDROITIN SULFATE; EPITOPE; MUCIN; PROTEIN ANTIBODY; PROTEOCHONDROITIN SULFATE;

ADULT; AIRWAY OBSTRUCTION; ARTICLE; BRONCHUS SECRETION; CENTRIFUGATION; CHRONIC LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; FEMALE; GEL ELECTROPHORESIS; HUMAN; IMMUNOASSAY; INCUBATION TIME; LEUKOCYTE; LUNG INFECTION; MALE; MUCUS SECRETION; PRIORITY JOURNAL; PROTEIN DEGRADATION; SLOT BLOT HYBRIDIZATION; SOLUBILITY; SPUTUM; SPUTUM ANALYSIS; SUPERNATANT; TURBIDITY; WESTERN BLOTTING;

ADULT; ANTIBODIES; BLOTTING, WESTERN; CHONDROITIN ABC LYASE; CYSTIC FIBROSIS; ELECTROPHORESIS, CELLULOSE ACETATE; FEMALE; HUMANS; MALE; MIDDLE AGED; MUCINS; PROTEOCHONDROITIN SULFATES; SOLUBILITY; SPUTUM;

EID: 0037385068     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000054780.11755.B9     Document Type: Article

References (49)

1. Snouwaert JN, Brigman KK, Latour AM, Malouf NN, Boucher RC, Smithies O, Koller BH 1992 An animal model for cystic fibrosis made by gene targeting. Science 257:1083-1088
2. Kent G, Oliver M, Kevin Foskett J, Frndova H, Durie P, Forstner J, Forstner GG, Riordan JR, Percy D, Buchwald M 1996 Phenotypic abnormalities in long-term surviving cystic fibrosis mice. Pediatr Res 40:233-241
3. Davis P, Drumm M, Konstan MW 1996 Cystic fibrosis. Am J Respir Crit Care Med 154:1229-1256
4. Puchelle E, Zahm J, Bentzmann S, Gaillard D 1997 Mucus and airway epithelium alterations in cystic fibrosis. In: Rogers DF, Lethem MI (eds) Airway Mucus: Basic Mechanisms and Clinical Perspectives. Birkhauser Verlag, Basel, Switzerland. pp 301-326
5. Bhaskar KR, Reid L 1980 Application of density gradient methods to study the composition of sol and gel phases of CF sputa and the isolation and characterization of epithelial glycoprotein from the two phases. In: Sturgess JM (ed) Perspectives in Cystic Fibrosis. Proceedings of the 8th International Cystic Fibrosis Congress, Toronto, Canada, pp 113-121
6. Potter JL, Spector S, Mathews, LW Lemm J 1969 Studies on Pulmonary secretions. The nucleic acids in whole pulmonary secretions from patients with cystic fibrosis, bronchiectasis and laryngectomy. Am Rev Respir Dis 99:909-916
7. Stern M, Alton EW 1997 Therapeutic approaches to the lung problems in cystic fibrosis. In: Rogers DF, Lethem MI (eds) Airway Mucus: Basic Mechanisms and Clinical Perspectives. Birkhauser Verlag, Basel, Switzerland, pp 341-364
8. Bhaskar KR, O'Sullivan DD, Seltzer J, Rossing TH, Drazen JM, Reid LM 1985 Density gradient study of bronchial mucus aspirates from healthy volunteers (smokers and non-smokers) and from patients with tracheostomy. Exp Lung Res 9:289-308
9. Bhaskar KR, O'Sullivan DD, Hincman HO, Reid LM, Coles SJ 1986 Density gradient analysis of secretions produced in vitro by human and canine airway mucosa: identification of lipids and proteoglycans in such secretions. Exp Lung Res 10:401-422
10. Boat TF, Cheng PW, Iyer RN, Carlson DM, Polony I 1976 Human respiratory tract secretions: mucous glycoproteins of nonpurulent tracheobronchial secretions, and sputum of patients with bronchitis and cystic fibrosis. Arch Biochem Biophys 177:95-104
11. Boat TF, Cheng PW, Wood RE 1976 Tracheobronchial mucus secretion in vivo and in vitro by epithelial tissues from cystic fibrosis and control subjects. Mod Probl Paediatr 19:141-152
12. LeTreut A, Lamblin G, Leray L, Guenet L, Filliat M, Roussel P 1984 Identification of degraded proteoglycans in the sputum of patients suffering from chronic bronchial hypersecretion. In: Lawson D (ed) Cystic Fibrosis: Horizons. John Wiley and Sons, NewYork, p 347
13. Gallagher JT, Kent PW 1975 Structure and metabolism of glycoproteins and glycosaminoglycans secreted by organ cultures of rabbit trachea. Biochem J 148:187-196
14. Paul A, Picard J, Mergey M, Veissiere D, Finkbeiner WE, Basbaum CB 1988 Glycoconjugates secreted by bovine tracheal serous cells in culture. Arch Biochem Biophys 260:75-84
15. Cheng PW, Boat TF, Cranfill JR, Yankaskas RC 1989 Increased sulfation of glycoconjugates by cultured nasal epithelial cells from patients with cystic fibrosis. J Clin Invest 84:68-72
16. Basbaum CB, Forsberg LS, Paul A, Sommerhoff C, Finkbeiner WE 1987 Studies of tracheal secretion using serous cell cultures and monoclonal antibodies. Biorheology 24:585-588
17. Rahmoune H, Lamblin G, Lafitte JJ, Galabert C, Filliat M, Roussel P 1991 Chondroitin sulfate in sputum from patients with cystic fibrosis and chronic bronchitis. Am J Respir Cell Mol Biol 5:315-320
18. Frates RC, Kaizu T, Last JA 1983 Mucous glycoproteins secreted by respiratory epithelial tissue from cystic fibrosis patients. Pediatr Res 17:30-34
19. Mohapatra NK, Cheng PW, Parker JC, Paradiso AM, Yankaskas JR, Boucher RC, Boat TF 1995 Alteration of sulfation of glycoconjugates, but not sulfate transport and intracellular inorganic sulfate content in cystic fibrosis airway epithelial cells. Pediatr Res 38:42-48
20. Bhaskar KR, Turner BS, Grubman SA, Jefferson DM, LaMont JT 1998 Dysregulation of proteoglycan production by intrahepatic biliary epithelial cells bearing defective (ΔF508) cystic fibrosis transmembrane conductance regulator. Hepatology 27:7-14
21. Kjellen L, Lindahl U 1991 Proteoglycans: structures and interactions. Annu Rev Biochem 60:443-475
22. Stockley RA, Bayley D, Hill SL, Hill AT, Crooks S, Campbell EJ 2001 Assessment of airway neutrophils by sputum colour: correlation with airways inflammation. Thorax 56:366-372
23. Bertolotto A, Palmucci L, Gagliano A, Mongini T, Tarone G 1986 Immunohistochemical localization of chondroitin sulfate in normal and pathological human muscle. J Neurol Sci 73:233-244
24. Koshino T, Bhaskar KR, Reid LM, Gerard C, Warner A, Shore SA, Anderson K, Butler G, Iijima H, Drazen JM 1990 Recovery of an epitope recognized by a novel monoclonal antibody from airway lavage during experimental induction of chronic bronchitis. Am J Respir Cell Mol Biol 2:453-462
25. Carlstedt I, Lindgren H, Sheehan JK 1983 The macromolecular structure of human cervical-mucus glycoproteins. Studies on fragments obtained after reduction of disulphide bridges and after subsequent trypsin digestion. Biochem J 213:427-435
26. Sajjan U, Reisman J, Doig P, Irvin RT, Forstner G, Forstner J 1992 Binding of non-mucoid Pseudomonas aeruginosa to normal human intestinal mucin and respiratory mucin from patients with cystic fibrosis. J Clin Invest 89:657-665
27. Redinbaugh MG, Turley RB 1986 Adaptation of the bicinchoninic acid protein assay for use with microtiter plates and sucrose gradient fractions. Anal Biochem 53:267-271
28. Cappelletti R, Rosso MD, Chiarugi VP 1979 A new electrophoretic method for the complete separation of all known glycosaminoglycans in a monodimensional run. Anal Biochem 99:311-315
29. Engelhardt JF, Yankaskas JR, Ernst SA, Yang Y, Marino CR, Boucher RC, Cohn JA, Wilson JM 1992 Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nat Genet 2:240-248
30. Brahimi-Horn MC, Deudon E, Paul A, Mergey M, Mailleau C. Basbaum C, Dohrman A, Capeau J 1994 Identification of decorin proteoglycan in bovine tracheal serous cells in culture and localization of decorin mRNA in situ. Eur J Cell Biol 64:271-280
31. Shirk RA, Parthasarathy N, San Antonio JD, Church FC, Wagner WD 2000 Altered dermatan sulfate structure and reduced heparin cofactor II-stimulating activity of biglycan and decorin from human athersclerotic plaque. J Biol Chem 275:18085-18092
32. Goldstein, W Doring G 1986 Lysosomal enzymes from polymorphonuclear leucocytes and proteinase inhibitors in patients with cystic fibrosis. Am Rev Respir Dis 134:49-56
33. Suter S, Schaad UB, Tegner H, Ohlsson K, Desgrandchamps D, Waldvogel FA 1986 Levels of free granulocyte elastase in bronchial secretions from patients with cystic fibrosis: effects of antimicrobial treatment against Pseudomonas aeruginosa. J Infect Dis 153:902-909
34. Houdret N, Ramphal R, Scharfman A, Perini J, Filliat M, Lamblin G, Roussel P 1989 Evidence for the in vivo degradation of human respiratory mucins during Pseudomonas aeruginosa infection. Biochim Biophys Acta 992:96-105
35. Hascall VC, Riolo RL, Howard JJ, Reynolds CC 1972 Treatment of bovine nasal cartilage proteoglycan with chondroitinase from Flavobacterium heparinum and Proteus vulgaris. J Biol Chem 247:4521-4528
36. Bhaskar KR, Brown R, O'Sullivan DD, Melia S, Duggan M, Reid L 1991 Bronchial mucus hypersecretion in acute quadriplegia: macromolecular yields and glycoconjugate composition. Am Rev Resp Dis 143:640-648
37. Forstner JF, Oliver MG, Sylvester FA 1995 Production, structure, and biologic relevance of gastrointestinal mucins, In: Blaser MJ, Smith PD, Ravdin JI, Greenberg HB, Guerrant HB (eds) Infections of the Gastrointestinal Tract. Raven Press, New York, pp 71-88
38. Yang H, Farooqui AA, Horrocks LA 1994 Effects of glycosaminoglycans and glycosphingolipids on cytosolic phospholipases A2 from bovine brain. Biochem J 299:91-95
39. Ruoslahti E 1989 Proteoglycans in cell regulation. J Biol Chem 264:13369-13372
40. Basbaum CB, Finkbeiner WE 1988 Airway secretion: a cell specific analysis. Horm Metab Res 20:661-667
41. Parmley RT, Rahemtulla F, Cooper MD, Roden L 1985 Ultrastructural and biochemical characterization of glycosaminoglycans in HNK-1 positive large granular lymphocytes. Blood 66:20-25
42. Rothenberg ME, Pomerantz JL, Owen Jr WF, Avraham S, Soberman RJ, Austen KF, Stevens RL 1988 Characterization of a human eosinophil proteoglycan, and augmentation of its biosynthesis and size by interleukin 3, interleukin 5 and granulocyte/macrophage colony stimulating factor. J Biol Chem 263:13901-13908
43. Hunningshake GW, Gadek JE, Kavanami O, Ferrans VJ, Crystal RG 1979 Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage. Am J Pathol 97:149-206
44. Sommerhoff CP, Nadel JA, Basbaum CB, Caughey GH 1990 Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells. J Clin Invest 85:682-689
45. Roussel P, Lamblin G, Degand P 1975 Heterogeneity of the carbohydrate chains of sulfated bronchial glycoproteins isolated from a patient suffering from cystic fibrosis. J Biol Chem 250:2114-2122
46. Chace KV, Leahy DS, Martin R, Carubelli R, Flux M, Sachdev GP 1983 Respiratory mucous secretions in patients with cystic fibrosis: relationship between levels of highly sulfated mucin component and severity of the disease. Clin Chim Acta 132:143-155
47. Dasgupta B, King M 1996 Reduction in viscoelasticity of cystic fibrosis sputum in vitro with combined treatment by nacystelyn and rhDNase. Pediatr Pulmonol 22:161-166
48. Vasconcellos CA, Allen PG, Wohl M, Drazen JM, Janmey PA 1994 Reduction in sputum viscosity of cystic fibrosis sputum in vitro by gelsolin. Science 263:969-971
49. Feng W, Garrett H, Speert DP, King M 1998 Improved clearability of cystic fibrosis sputum with dextran treatment in vitro. Am J Respir Crit Care Med 157:710-714