Pressor response to chemoreflex activation before and after microinjection of glycine into the NTS of awake rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 284, Issue 4 53-4, 2003, Pages

  Pimentel, Franklin F ^a   Bonagamba, Leni G H ^a   Machado, Benedito H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Autonomic regulation; Cardiovascular regulation; Glycine receptors; Sympathetic activity

Indexed keywords

GLYCINE; GLYCINE RECEPTOR; NITROPRUSSIDE SODIUM; POTASSIUM CYANIDE; STRYCHNINE;

ANIMAL EXPERIMENT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CARDIOVASCULAR AUTOREGULATION; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; INFERIOR COLLICULUS; MALE; MEAN ARTERIAL PRESSURE; NEUROTRANSMISSION; NONHUMAN; PRESSOR RESPONSE; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; SOLITARY TRACT NUCLEUS; SUPERIOR COLLICULUS; SYMPATHETIC TONE; WAKEFULNESS;

EID: 0037384683     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00310.2002     Document Type: Article

References (27)

1. Bennett JA, McWillian PN, and Shepheard SL. Gama-aminobutyric-acid mediated inhibition of neurons in the nucleus tractus solitarii of the cat. J Physiol 392: 417-430, 1987.
2. Callera JC, Bonagamba LGH, Nosjean A, Laguzzi R, and Machado BH. Activation of GABAA but not GABAB receptors in the NTS blocked bradycardia of chemoreflex in awake rats. Am J Physiol Heart Circ Physiol 276: H1902-H1910, 1999.
3. 3 receptor agonist into the NTS of unanesthetized rats inhibits the cardiovagal component of the baro- and chemoreflex. JAuton Nerv Syst 63: 127-136, 1997.
4. Ciriello J, Hochstenbach SL, and Roder S. Central projection of baroreceptor and chemoreceptor afferent fibers in the rat. In: Nucleus of the Solitary Tract, edited by Robin I and Barraco A. Orlando, FL: CRC, 1994, p. 35-50.
5. Curtis DR, Duggan AW, and Johnston GAR. The specificity of strychnine as a glycine antagonist in the mammalian spinal cord. Exp Brain Res 12: 547-565, 1971.
6. DeFeudis FV, Orensanz Muñoz LM, and Fando JL. High-affinity glycine binding sites in rat CNS: regional variation and strychnine sensitivity. Gen Pharmacol 9: 171-176, 1978.
7. De Paula PM and Machado BH. Antagonism of adenosine A1 receptors in the NTS does not affect the chemoreflex in awake rats. Am J Physiol Regul Integr Comp Physiol 281: R2072-R2078, 2001.
8. Donoghue S, Felder RB, Jordan D, and Spyer KM. The central projection of carotid baroreceptor and chemoreceptor in the cat: a neurophysiological study. J Physiol 347: 397-410, 1984.
9. Franchini KG and Krieger EM. Carotid chemoreceptors influence arterial pressure in intact and aortic denervated rats. Am J Physiol Regul Integr Comp Physiol 262: R677-R683, 1992.
10. Franchini KG and Krieger EM. Cardiovascular responses of conscious rats to carotid body chemoreceptor stimulation by intravenous KCN. J Auton Nerv Syst 42: 63-70, 1993.
11. Haibara AS, Bonagamba LGH, and Machado BH. Sympathoexcitatory neurotransmission of chemoreflex in the NTS of awake rats. Am J Physiol Regul Integr Comp Physiol 276: R69-R80, 1999.
12. Haibara AS, Colombari E, Chianca DA Jr, Bonagamba LGH, and Machado BH. NMDA receptors in the NTS are involved in bradycardic but not in pressor response of chemoreflex. Am J Physiol Heart Circ Physiol 269: H1421-H1427, 1995.
13. Housley GD, Martin-Body RL, Dawson NJ, and Sinclair JD. Brain stem projection of the glossopharyngeal nerve and its carotid sinus branch in the rat. Neuroscience 22: 237-250, 1987.
14. Kubo T and Kihara M. Evidence for the presence of GABAergic and glycine-like systems responsible for cardiovascular control in the nucleus tractus solitarii of the rat. Neurosci Lett 74: 331-336, 1987.
15. Kubo T and Kihara M. β-Alanine, like glycine, microinjected into the rat nucleus tractus solitarii increases blood pressure. Clin Exp Hypertens A 12: 1351-1360, 1990.
16. Mauad H, Colombari E, Bonagamba LGH, and Machado BH. Glycine blocks the pressor response to L-glutamate micro-injected into the nucleus tractus solitarii of conscious rats. Braz J Med Biol Res 28: 699-704, 1995.
17. Mauad H and Machado BH. Involvement of ipsilateral rostral ventrolateral medulla in the pressor response to L-glutamate microinjection into the nucleus tractus solitarii of awake rats. J Auton Nerv Syst 74: 43-48, 1998.
18. Mauad H and Machado BH. Pressor response to unilateral carotid chemoreceptor activation is not affected by ipsilateral blockade of excitatory amino acid receptors in the rostral ventrolateral medulla in awake rats. Auton Neurosci 91: 26-31, 2001.
19. Michelini LC and Bonagamba LGH. Baroreceptor reflex modulation by vasopressin microinjected into the nucleus tractus solitarii of conscious rats. Hypertension 11, Suppl I: 175-179, 1988.
20. Mifflin SW. Arterial chemoreceptor input to nucleus tractus solitarius. Am J Physiol Regul Integr Comp Physiol 263: R368-R375, 1992.
21. Paxinos G and Watson C. The Rat Brain in Stereotaxic Coordinates. Sydney, Australia: Academic, 1986.
22. Spyer KM. The central nervous organization of reflex circulatory control. In: Central Regulation of Autonomic Functions, edited by Loewy AD and Spyer KM. New York: Oxford Univ. Press, 1990, p. 168-188.
23. Talman WT and Robertson SC. Glycine, like glutamate, microinjected into the nucleus tractus solitarii of rat decreases arterial pressure and heart rate. Brain Res 477: 7-13, 1989.
24. White WF, Brown KL, and Frank DM. Glycine binding to rat cortex and spinal cord: binding characteristics and pharmacology reveal distinct populations of sites. J Neurochem 53: 503-512, 1989.
25. Wu WC, Kuo JS, Wang Y, and Chay CY. Glycine increases arterial pressure and augments NMDA-induced pressor responses in the dorsomedial and ventrolateral medulla of cats. J Auton Nerv Syst 67: 145-155, 1997.
26. Zhang C, Bonagamba LGH, and Machado BH. Blockade of NK-1 receptors in the lateral commissural nucleus tractus solitarii of awake rats had no effect on the cardiovascular responses to chemoreflex activation. Braz J Med Biol Res 33: 1379-1385, 2000.
27. Zhang W and Mifflin SW. Excitatory amino acid receptors within NTS mediate arterial chemoreceptor reflexes in rats. Am J Physiol Heart Circ Physiol 265: H770-H773, 1993.