Pulmonary hypertension in patients with COPD: NO treatment?

Thorax

Volumn 58, Issue 4, 2003, Pages 283-284

  Pepke Zaba, J ^a   Morrell, N W ^a,b  

^a PAPWORTH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; OXYGEN; OXYHEMOGLOBIN;

BLOOD VESSEL TONE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; DOPPLER ECHOCARDIOGRAPHY; DRUG EFFICACY; HEART CATHETERIZATION; HUMAN; INTENSIVE CARE; LUNG HEMODYNAMICS; OXYGEN THERAPY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; REVIEW; SYSTEMIC CIRCULATION; VASCULAR DISEASE; VASODILATATION;

ADMINISTRATION, INHALATION; HUMANS; HYPERTENSION, PULMONARY; NITRIC OXIDE; OXYHEMOGLOBINS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; VASODILATION; VASODILATOR AGENTS;

EID: 0037383217     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thorax.58.4.283     Document Type: Review

References (20)

1. www.nobel.se/medicine/laureats/1998
2. Stamler JS, Loh E, Roddy MA, et al. Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation 1994;89:2035-40.
3. Dinh-Xuan AT, Higenbottam TW, Clelland CA, et al. Impairment of endothelium-dependent pulmonary artery relaxation in chronic obstructive lung disease. N Engl J Med 1991;324:1539-47.
4. Peinado VI, Barbera JA, Ramirez J, et al. Endothelial dysfunction in pulmonary arteries of patients with mild COPD. Am J Physiol Lung Cell Mol Physiol 1998;274:L908-13.
5. Pepke-Zaba J, Higenbottam TW, Dinh-Xuan AT, et al. Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. Lancet 1991;338:1173-4.
6. Carlsen E, Comroe JH. The rate of uptake of carbon monoxide and of nitric oxide by normal human erythrocytes and experimentally produced spherocytes. J Gen Physiol 1958;42:83-107.
7. Cannon RO III, Schechter AN, Panza JA, et al. Effecfs of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxidedelivery. J Clin Invest 2001;108:279-87.
8. Ford PC, Wink DA, Stanbury DM. Autoxidation kinetics of aqueous nitric oxide. FEBS Lett 1993;326:1-3.
9. Kinsella JP, Neish SR, Shaffer E, et al. Low dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 1992;340:819-20.
10. Weitzenblum E, Loiseau A, Hirth C, et al. Course of pulmonary hemodynamics in patients with chronic obstructive pulmonary disease. Chest 1979;75:656-62.
11. Weitzenblum E, Hirth C, Ducolone A, et al. Prognostic value of pulmonary artery pressure in chronic obstructive pulmonary disease. Thorax 1981;36:752-8.
12. Higham MA, Dawson D, Joshi J, et al. Utility of echocardiography in assessment of pulmonary hypertension secondary to COPD. Eur Respir J 2001;17:350-5.
13. Incalzi RA, Fuso L, De Rosa M, et al. Electrocardiographic signs of chronic cor pulmonale: a negative prognostic finding in chronic obstructive pulmonary disease. Circulation 1999;99:1600-5.
14. Kessler R, Faller M, Fourgaut G, et al. Predictive factors of hospitalization for acute exacerbation in a series of 64 patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999;159:158-64.
15. Santos S, Peinado VI, Ramirez J, et al. Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD. Eur Respir J 2002;19:632-8.
16. Zhang W, Yatskievych TA, Cao X, et al. Regulation of Hex gene expression by a Smads-dependent signaling pathway. J Biol Chem 2002;277:45435-41.
17. Germann P, Ziesche R, Leitner C, et al. Addition of nitric oxide to oxygen improves cardiopulmonary function in patients with severe COPD. Chest 1998;114:29-35.
18. Katayama Y, Higenbottam TW, Diaz de Atauri MJ, et al. Inhaled nitric oxide and arterial oxygen tension in patients with chronic obstructive pulmonary disease and severe pulmonary hypertension. Thorax 1997;52:120-4.
19. Roger N, Barbera JA, Roca J, et al. Nitric oxide inhalation during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1997;156:800-6.
20. Vonbank K, Ziesche R, Higenbottam TW, et al. Controlled prospective randomised trial on the effects on pulmonary haemodynamics of the ambulatory long term use of nitric oxide and oxygen in patients with severe COPD Thorax 2003;58:289-93.