Conformational and biological studies for a pair of novel synthetic AT1 antagonists: Stereoelectronic requirements for antihypertensive efficacy

Journal of Pharmaceutical and Biomedical Analysis

Volumn 31, Issue 5, 2003, Pages 833-844

  Zoumpoulakis, P ^a   Zoga, A ^a,d   Roumelioti, P ^c   Giatas, N ^c   Grdadolnik, S G ^b   Iliodromitis, E ^d   Vlahakos, D ^d   Kremastinos, D ^d   Matsoukas, J M ^c   Mavromoustakos, T ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

^b NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^c UNIVERSITY OF PATRAS   (Greece)

^d ONASSIS CARDIAC SURGERY CENTER   (Greece)

Author keywords

Antihypertensives; AT1 antagonists; Losartan; Molecular modeling; NMR

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; BZ 18; LOSARTAN; LOSARTAN POTASSIUM; V 12;

ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BIOLOGY; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG EFFICACY; DRUG MARKETING; DRUG SYNTHESIS; HYPERTENSION; NONHUMAN; PRIORITY JOURNAL; RABBIT; RECEPTOR BINDING; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

EID: 0037382955     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(02)00655-6     Document Type: Article

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