Wnts as morphogens? The view from the wing of Drosophila

Nature Reviews Molecular Cell Biology

Volumn 4, Issue 4, 2003, Pages 321-325

  Martinez Arias, Alfonso ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHOGEN; WNT PROTEIN;

CELL FATE; DROSOPHILA; GENE EXPRESSION; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN SECRETION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BODY PATTERNING; DROSOPHILA; EMBRYO, NONMAMMALIAN; MORPHOGENESIS; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; WING; WNT PROTEINS; ZEBRAFISH PROTEINS;

HEXAPODA;

EID: 0037381292     PISSN: 14710072     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrm1078     Document Type: Review

References (29)

1. Wolpert, L. Positional information revisited. Development (suppl.) 107, 3-12 (1989).
2. Neumann, C. & Cohen, S. M. Morphogens and pattern formation. BioEssays 19, 721-729 (1997).
3. Gurdon, J. B. & Bourillot, P.-Y. Morphogen gradient interpretation. Nature 413, 797-803 (2001).
4. Martinez Arias, A. & Stewart, A. Molecular Principles of Animal Development (Oxford Univ. Press, Oxford, 2002).
5. Nusse, R. & Varmus, H. Wnt genes. Cell 69, 1073-1087 (1992).
6. 1) mutation on wing and haltere development in Drosophila melanogaster. Dev. Biol. 48, 461-465 (1976).
7. Couso, J. P., Bate, C. M. & Martinez Arias, A. A wingless-dependent polar coordinate system in the imaginal discs of Drosophila. Science 259, 484-489 (1993).
8. Baker, N. Molecular cloning of sequences from wingless, a segment polarity gene in Drosophila: the spatial distribution of a transcript in embryos. EMBO J. 6, 1765-1774 (1987).
9. Gonzalez, F., Bejsovec, A., Skaer, H. & Martinez Arias, A. Secretion and movement of the wingless gene product in Drosophila embryos. Mech. Dev. 35, 43-54 (1991).
10. Stringini, M. & Cohen, S. M. Wingless gradient formation in the Drosophila wing. Curr. Biol. 10, 293-300 (2000).
11. Bejsovec, A. & Martinez Arias, A. Roles of wingless in the patterning of the epidermis in Drosophila. Development 113, 471-485 (1991).
12. Baylies, M. K., Martinez Arias, A. & Bate, M. wingless is required for the formation of a subset of muscle founder cells during Drosophila embryogenesis. Development 121, 3829-3837 (1995).
13. Ingham, P. & Martinez Arias, A. Boundaries and fields in early embryos. Cell 68, 221-235 (1992).
14. Martinez Arias, A., Baker, N. & Ingham, P. The role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo. Development 103, 157-170 (1988).
15. Di Nardo, S., Sher, E., Heemskerk-Jongens, J., Kassis, J. A. & O'Farrell, P. H. Two tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis. Nature 332, 604-609 (1988).
16. Payre, F., Vincent, A. & Carreno, S. ovo/svb integrates Wingless and DER pathways to control epidermis differentiation. Nature 400, 271-275 (1999).
17. Struhl, G. & Basler, K. Organizing activity of wingless protein in Drosophila. Cell 72, 527-540 (1993).
18. Neumann, C. J. & Cohen, S. M. A hierarchy of crossregulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing. Development 122, 3477-3485 (1996).
19. Zecca, M., Basler, K. & Struhl, G. Direct and long range action of a wingless morphogen gradient. Cell 87, 833-844 (1996).
20. Klein, T. & Martinez Arias, A. Different spatial and temporal interactions between Notch, wingless and vestigial specify proximal and distal pattern elements of the wing in Drosophila. Dev. Biol. 194, 196-212 (1998).
21. Klein, T. & Martinez Arias, A. The Vestigial gene product provides a molecular context for the interpretation of signals during the development of the wing in Drosophila. Development 126, 913-925 (1999).
22. Martinez Arias, A. The informational content of gradients of Wnt proteins. Sci. STKE 43, PE1 (2000).
23. Ng, M., Diaz Benjumea, F. J., Vincent, J. P., Wu, J. & Cohen, S. M. Specification of the wing primordium in Drosophila. Nature 381, 316-319 (1996).
24. Garcia-Garcia, M. J., Ramain, P., Simpson, P. & Modolell, J. Different contributions of pannier and wingless to the patterning of the dorsal mesothorax of Drosophila. Development 126, 3523-3532 (1999).
25. Phillips, R. G. Warner, N. L. & Whittle, J. R. Wingless signaling leads to an asymmetric response to decapentaplegic-dependent signaling during sense organ patterning on the notum of Drosophila melanogaster. Dev. Biol. 207, 150-162 (1999).
26. Couso, J. P., Bishop, S. & Martinez Arias, A. The wingless signalling pathway and the patterning of the wing margin. Development 120, 621-636 (1994).
27. Martinez Arias, A., Zecchini, V. & Brennan, K. CSL-independent Notch signalling: a checkpoint in cell fate decisions in development? Curr. Opin. Genet. Dev. 12, 524-533 (2002).
28. Galceran, J., Hsu, S. C. & Grosschedl, R. Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression. Proc. Natl Acad. Sci. USA 98, 8668-8673 (2001).
29. Wheeler, J. C., VanderZwan, C., Xu, X., Swantek, D., Tracey, W. D. & Gergen J. P. Distinct in vivo requirements for establishment versus maintenance of transcriptional repression. Nature Genet. 32, 206-210 (2002).