Effect of route of administration on the pharmacokinetic behavior of enantiomers of nefopam and desmethylnefopam

Therapeutic Drug Monitoring

Volumn 25, Issue 2, 2003, Pages 203-210

  Chawla, Jyoti ^a   Le Guern, Marie Emmanuelle ^b   Alquier, Christine ^b   Kalhorn, Thomas F ^a   Levy, René H ^a,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Service de Pharmacologie   (France)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Analgesia; Circulating metabolites; Desmethylnefopam; Nefopam; Stereoselectivity

Indexed keywords

ANALGESIC AGENT; DRUG METABOLITE; NEFOPAM; NORNEFOPAM; PLACEBO; UNCLASSIFIED DRUG;

ADULT; ANALGESIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CHIRALITY; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEMETHYLATION; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG ADMINISTRATION ROUTE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG URINE LEVEL; ENANTIOMER; FIRST PASS EFFECT; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NORMAL HUMAN; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RACEMIC MIXTURE; RANDOMIZED CONTROLLED TRIAL; STEREOCHEMISTRY; URINARY EXCRETION;

ADMINISTRATION, ORAL; ADULT; ANALGESICS, NON-NARCOTIC; AREA UNDER CURVE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; HALF-LIFE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; METABOLIC CLEARANCE RATE; NEFOPAM; STEREOISOMERISM;

EID: 0037381144     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200304000-00010     Document Type: Article

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