Sildenafil does not alter nelfinavir pharmacokinetics

Therapeutic Drug Monitoring

Volumn 25, Issue 2, 2003, Pages 240-242

  Bratt, Göran ^a   Ståhle, Lars ^b  

^a STOCKHOLM SÖDER HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Drug interaction; HIV; Indinavir; Nelfinavir; Ritonavir; Saquinavir; Sildenafil

Indexed keywords

ACICLOVIR; AMILORIDE; ATENOLOL; BENDROFLUMETHIAZIDE; COTRIMOXAZOLE; CYCLIZINE; DIDANOSINE; EFAVIRENZ; HYDROCHLOROTHIAZIDE; INDINAVIR; LAMIVUDINE; MOCLOBEMIDE; NELFINAVIR; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; SILDENAFIL; STAVUDINE; ZIDOVUDINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFECT; DRUG HALF LIFE; DRUG METABOLISM; ENZYME INHIBITION; ERECTILE DYSFUNCTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; PRIORITY JOURNAL;

ADULT; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; HALF-LIFE; HIV INFECTIONS; HIV PROTEASE INHIBITORS; HUMANS; IMPOTENCE; INDINAVIR; MALE; MIDDLE AGED; NELFINAVIR; PIPERAZINES; RITONAVIR; SAQUINAVIR; VASODILATOR AGENTS;

EID: 0037380867     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200304000-00016     Document Type: Article

References (4)

1. Hyland R, Roe EGH, Jones BC, et al. Identification of the cytochrome P450 enzymes involved in the N-demethylation of silde nafil. Br J Clin Pharmacol 2001;51:239-48.
2. Merry C, Barry MG, Ryan M, et al. Interaction of sildenafil and indinavir when co-administered to HIV-positive patients. AIDS 1999;13:F101-7.
3. Muirhead GJ, Wulff MB, Fielding A, et al. Pharmacokinetic interactions between sildenafil and saquinavir/ritonavir. Br J Clin Pharmacol 2000;50:99-107.
4. Svensson J-O, Sönnerborg A, Ståhle L. Rapid and simple determination of indinavir in serum, urine and cerebrospinal fluid using high-performance liquid chromatography. Ther Drug Monit 2000;22:626-9.