Peptidergic innervation in the rat carotid body after 2, 4, and 8 weeks of hypocapnic hypoxic exposure

Histology and Histopathology

Volumn 18, Issue 2, 2003, Pages 409-418

  Kusakabe, Tatsumi ^a   Hirakawa, H ^b   Matsuda, H ^c   Kawakami, T ^d   Takenaka, T ^a   Hayashida, Y ^b  

^a KOKUSHIKAN UNIVERSITY   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

^d KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Carotid body; Hypoxic exposure; Immunohistochemistry; Rat; Regulatory neuropeptides

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; NEUROPEPTIDE; NEUROPEPTIDE Y; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;

ACCLIMATIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL; BLOOD VESSEL INNERVATION; CAROTID BODY; CONTROLLED STUDY; DENSITY; HYPOCAPNIA; HYPOXIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LONG TERM EXPOSURE; NERVE FIBER; NONHUMAN; OXYGEN TENSION; PEPTIDERGIC NERVOUS SYSTEM; RAT;

ANIMALS; ANOXIA; CALCITONIN GENE-RELATED PEPTIDE; CAROTID BODY; COLORING AGENTS; EOSINE YELLOWISH-(YS); FLUORESCENT DYES; HEMATOXYLIN; HYPOCAPNIA; IMMUNOHISTOCHEMISTRY; MUSCLE, SMOOTH, VASCULAR; NERVE FIBERS; NEUROPEPTIDE Y; NEUROPEPTIDES; RATS; SUBSTANCE P; TIME FACTORS; VASOACTIVE INTESTINAL PEPTIDE;

ANIMALIA;

EID: 0037379423     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Barrer G.R., Edwards C. and Jolly A.I. (1976). Changes in the carotid body and the ventilatory response to hypoxia in chronically hypoxic rats. Clin Sci. 50, 311-313.
2. Blessing M.H. and Wolff H. (1973). Befunde an glomus caroticum der ratte nach aufenhalt im einer simulierten höhe von 7500m. Virchow Arch. Pathol. Anat. Physiol. 360, 78-97.
3. Brain S.D., Williams T.J., Tippins J.R., Moris H.R. and MacIntyre I. (1985). Calcitonin gene-related peptide is a potent vasodilator, Nature (Lond) 313, 54-56.
4. Chen L., Yates R.D. and Hansen J.T. (1986). Substance P-like immunoreactivity in rat and cat carotid bodies: Light and electron microscopic studies. Histol. Histopathol. 1, 203-212.
5. Cragg P.A., Runold M., Kou Y.R. and Prabhakar N.R. (1994). Tachykinin antagonists in carotid body responses to hypoxia and substance P in the rat. Respir. Physiol. 95, 295-310.
6. Dhillon D.P., Barer G.R. and Walsh M. (1984). The enlarged carotid body of the chronically hypoxic and chronically hypoxic and hypercapnic rat: A morphometric analysis. Quart. J. Exp. Physiol. 69, 301-317.
7. Edvinsson L. and Uddman R. (1982). Immunohistochemical localization and dilatatory effect of substance P on human cerebral vessels, Brain Res. 232, 466-471.
8. Edvinsson L., McCulloch J. and Uddman R. (1981). Substance P: Immunohistochemical localization and effect upon feline pial arteries in vitro and in situ, J. Physiol. (Lond) 318, 251-258.
9. Edvinsson L., Emson P., McCulloch J., Teramoto K., and Uddman R. (1983). Neuropeptide Y: Cerebrovascular innervation and vasomotor effects in the cat, Neurosci. Lett. 43, 79-84.
10. Eyzaguirre C., Monti-Bloch L., Hayashida Y. and Baron M. (1983) Biophysics of the carotid body receptor complex. In: Physiology of the Peripheral Arterial Chemoreceptors. Acker H. and O'Regan R.G. (eds). Elsevier. Amsterdam. pp 59-87.
11. Hallberg D. and Pernow B. (1975) Effect of substance P on various vascular beds in the dog. Acta Physiol. Scand. 93, 227-285.
12. Heath D., Edwarda C., Winson M. and Smith P. (1973). Effects on the right ventricle, pulmonary vasculature, and carotid bodies of the rat of exposure to, and recovery from, simulated high altitude. Thorax 28, 24-28.
13. Helke C.J., O'Donohue T.J. and Jacobowitz D.M. (1980). Substance P as a baro- and chemoreceptor afferent neurotransmitter: Immunohistochemical and neurochemical evidence in the rat. Peptides 1, 1-9.
14. Hirakawa H., Nakamura T. and Hayashida Y. (1997). Effect of carbon dioxide on autonomic cardiovascular responses to systemic hypoxia in conscious rats. Am. J. Physiol. 273, R747-R754.
15. Jacobowitz D.M. and Helke C.J. (1980). Localization of substance P immunoreactive nerves in the carotid body. Brain Res. Bull. 5, 195-197.
16. Kusakabe T., Anglade P. and Tsuji S. (1991). Localization of substance P, CGRP, VIP, neuropeptide Y, and somatostatin immunoreactive nerve fibers in the carotid labyrinths of some amphibian species. Histochemistry 96, 255-260.
17. Kusakabe T., Powell F.L. and Ellisman M.H. (1993). Ultrastructure of the glomus cells in the carotid body of chronically hypoxic rats: With special reference to the similarity of amphibian glomus cells. Anat. Rec. 237, 220-227.
18. Kusakabe T., Matsuda H., Harada H., Hayashida Y., Gono Y., Kawakami T. and Takenaka T. (1998a). Changes in the distribution of nitric oxide synthase immunoreactive nerve fibers in the chronically hypoxic rat carotid body. Brain Res. 795, 292-296.
19. Kusakabe T., Hayasnida Y., Matsuda H., Gono Y., Powell F.L., Ellisman M.H., Kawakami T. and Takenaka T. (1998b). Hypoxic adaptation of the peptidergic innervation in the rat carotid body. Brain Res. 806, 165-174.
20. Kusakabe T., Hayashida Y., Matsuda H., Kawakami T. and Takenaka T. (2000). Changes in the peptidergic innervation of the carotid body a month after the termination of chronic hypoxia. Adv. Exp. Med. Biol. 793-799.
21. 2 tension. Histol. Histopathol. 17, 21-29.
22. Laider P. and Kay J.M. (1975a) A quantitative morphological study of the carotid bodies of rats living at a simulated altitude of 4300 meters. J. Pathol. 117, 183-191.
23. Laider P. and Kay J.M. (1975b). The effect of chronic hypoxia on the number and nuclear diameter of type I cells in the carotid bodies of rats. Am. J. Pathol. 79, 311-320.
24. Laider P. and Kay J.M. (1978). A quantitative study of some ultrastructural features of the type I cells in carotid bodies of rats living at a simulated altitude of 4300 meters. J. Neurocytol. 7, 183-192.
25. Lundberg J.M. and Hökfelt T. (1983). Coexistence of peptides and classical neurotransmitters. Trends Neurosci. 6, 325-333.
26. Lundberg J.M., Terenis L., Hökfelt T., Martling C.R., Tatemoto K., Mutt V., Polak J., Bloom S. and Goldstei M. (1982). Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function. Acta Physiol. Scand. 116, 477-480.
27. McGregor K.H., Gil J. and Lahiri S. (1984). A morphometric study of the carotid body in chronically hypoxic rats. J. Appl. Physiol. 57, 1430-1438.
28. McQueen D.S. (1980). Effects of substance P on carotid chemoreceptor activity in the cat. J. Physiol. (Lond) 302, 31-47.
29. Moller M., Mollgard K. and Sorensen S.C. (1974). The ultrastructure of the carotid body in chronically hypoxic rabbits. J. Physiol. (Lond). 238, 447-453.
30. Pallot D.J., Bee D., Barer G.R. and Jacob S. (1990). Some effects of chronic stimulation on the rat carotid body, In: Arterial Chemoreception. Eyzaguirre C., Fidone S.J., Fitgerald R.S., Lahiri S. and McDonald D.M. (eds). Springer-Verlag. New York. pp 293-301.
31. Pequignot J.M. and Hellström S. (1983). Intact and sympathectomized study of the carotid bodies of long term hypoxic rats: A morphometric light microscopical study. Virchow Arch. Pathol Anat. 400, 235-243.
32. Pequignot J.M., Hellström S. and Johansson C. (1984). Intact and sympathectomized study of the carotid bodies of long term hypoxic rats: A morphometric ultrastructural study. J. Neurocytol. 13, 481-493.
33. Samnegard H., Thulin L., Tyden G., Johansson C., Muhrberg O. and Björklund C. (1978). Effect of synthetic substance P on internal carotid artery blood flow in man. Acta Physiol. Scand. 104, 492-495.
34. Toews S.P. and Heisler N. (1982). The effects of hypercapnia on intracellular and extracellular acid-base status in the toad Bufo marinus. J. Exp. Biol. 97, 79-86.
35. West N.H., Topor Z.L. and Vliet B.N. (1987). Hypoxemic threshold for lung ventilation in the toad. Respir. Physiol. 70, 377-390.
36. Wharton J., Polak J.M., Pearse A.G.E., McGregor G.P., Bryant M.G., Bloom S.R., Emson P.C., Bisgard G.E. and Will J.A. (1980). Enkephalin-, VIP- and substance P-like immunoreactivity in the carotid body. Nature 284, 269-271.
37. Wilson D.A., O'Neil J.T., Saido S.I. and Traystman R.J. (1981). Vasoactive intestinal polypeptide and canine cerebral circulation. Circ. Res. 48, 138-148.