Sustained-release diltiazem reduces myocardial ischemic episodes in end-stage renal disease: A double-blind, randomized, crossover, placebo-controlled trial

Journal of the American Society of Nephrology

Volumn 14, Issue 4, 2003, Pages 1006-1011

  Cice, Gennaro ^a   Di Benedetto, Attilio ^b   D'Andrea, Antonello ^a   D'Isa, Salvatore ^a   Ferrara, Luigi ^a   Russo, Pina Elvira ^a   Iacono, Aldo ^a   Calabrò, Raffaele ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b Fresenius Medical Care Italia   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DILTIAZEM; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HEART MUSCLE ISCHEMIA; HEMODIALYSIS; HOLTER MONITORING; HUMAN; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; SUSTAINED RELEASE PREPARATION; TRANSIENT ISCHEMIC ATTACK;

EID: 0037378034     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000059309.66107.FC     Document Type: Article

References (28)

1. US Renal Data System: 1999 Annual Data Report. Am J Kidney Dis 34: S1, 1999
2. de Lemos JA, Hillis LD: Diagnosis and management of coronary artery disease in patients with end-stage renal disease on hemodialysis. J Am Soc Nephrol 7: 2044-2054, 1996
3. Goldsmith DJ, Covic A: Coronary artery disease in uremia: Etiology, diagnosis, therapy. Kidney Int 60: 2059-2078, 2001
4. Mulcahy D, Keegan J, Crean P, Quyyumi A, Shapiro L, Wright C, Fox K: Silent myocardial ischemia in chronic stable angina: A study of its frequency and characteristics in 150 patients. Br Heart J 60: 417-423, 1988
5. Cecchi AC, Dovellini EV, Marchi F, Pucci P, Santoro GM, Fazzini PF: Silent myocardial ischemia during ambulatory electrocardiographic monitoring in patients with effort angina. J Am Coll Cardiol 1: 934-939, 1983
6. Gonsorcik j, Szakacs M, Palko S, Mydlik M: Pharmacotherapy of silent myocardial ischemia in patients on hemodialysis. Vnitr Lek 42: 837-841, 1996
7. Cice G, Di Benedetto A, Aquino D, Tagliamonte E, Ferrara L, Sorice P, Iacono A: Angina silente in pazienti uremici dializzati: studio di comparazione tra carvedilolo e diltiazem. Giorn It Nefrol 14: 389-396, 1997
8. Cice G, Di Benedetto A, Sarubbi B, Tedesco MA, Iacono A: Ischemia silente in pazienti in trattamento dialitico. Cardiologia 39: 629-632, 1994
9. Conlon PJ, Krucoff MW, Minda S: Incidence and long-term significance of transient ST segment deviation in hemodialysis patients. Clin Nephrol 49: 236-242, 1998
10. Deedwania P, Carbajal E, Nelson J, Linn L: Silent ischemia during daily life is an indipendent predictor of survival in stable angina. Circulation 81: 748-756, 1990
11. Yeung AC, Barry J, Orav J, Bonassin E, Raby KE, Selwyn AP: Effects of asymptomatic ischemia on long term prognosis in chronic stable coronary disease. Circulation 83: 1598-1604, 1991
12. Gottlieb SO, Gottlieb SH, Achuff SC, Baumgardner R, Mellits ED, Weisfeldt ML, Gerstenblith G: Silent ischemia on Holter monitoring predicts mortality in high-risk postinfarction patients. JAMA 259: 1030-1035, 1988
13. Geft IL, Fishbein MC, Ninomiya K, Hashida J, Chaux E, Yano J, Y-Rit J, Genov T, Shell W, Ganz W: Intermittent brief periods of ischemia have a cumulative effect and may cause myocardial necrosis. Circulation 66: 1150-1153, 1982
14. Matsumoto N, Ideishi M, Sasaguri M, Nii T, Nakashima Y, Arakawa K: Effects of slow-release nifedipine on 24-hour ambulatory blood pressure and ischemic changes on 24-hour ambulatory electrocardiogram in patients with severe coronary artery disease. Cardiology 94: 36-43, 2000
15. Elsner D: How to diagnose and treat coronary artery disease in uremic patients: an update. Nephrol Dial Transplant 16: 1103- 1108, 2001
16. Cice G, Di Benedetto A, Tagliamonte E, Ferrara L, Sorice P, Iacono A: Efficacia e tollerabilità di bisoprololo e nifedipina in pazienti con cardiopatia ischemica in trattamento dialitico. Cardiologia 42: 397-403, 1997
17. Hossack KF, Pool PE, Steele P, Crawford MH, De Maria AN, Cohen LS, Ports TA: Efficacy of diltiazem in angina on effort: a multicenter trial. Am J Cardiol 49: 567-572, 1982
18. Go M, Hollenberg M: Improved efficacy of high-dose versus medium- and low-dose diltiazem therapy for chronic stable angina pectoris. Am J Cardiol 53: 669-673, 1984
19. Juneau M, Theroux P: Effect of diltiazem slow-release formulation on silent myocardial ischemia in stable coronary artery disease. Am J Cardiol 69: 30B-35B, 1992
20. Morselli PI, Rovel V, Mitchard M, Durand A, Gomeni R: Pharmacokinetics and metabolism of diltiazem in man (observation on healthy volunteers and angina pectoris patients). In: New Drug Therapy with a Calcium Antagonist, edited by Bing RJ, Amsterdam, Princeton, Expcerpta Medica, 1979, pp 152-168
21. Bighley LD, Dimmit DC, KcGraw BF: Bioavailability of diltiazem hydrochloride formulations. Clin Res 28: 587A, 1980
22. Koiwaya Y, Ashiara T, Nakamura M, Etoh A: Plasma concentration of diltiazem after oral administration in normal volunteers. Clin Ther 3: 436-440, 1981
23. Zelis R, Kinney EL: The pharmacokinetics of diltiazem in healthy American men. Am J Cardiol 49: 529-532, 1982
24. Gordin A, Photo P, Sundberg S, Nykanen S, Haataja H: Pharmacokinetics of slow-release diltiazem and its effect on atrioventricular conduction in healthy volunteers. Eur J Clin Pharmacol 31: 423-426, 1986
25. Campistron G, Rostin M, Coulais Y, Caillard C, Zarrouk G, Frances J, Thiercellin JF, Montastruc JL, Houin G: Effect of size and dosage strength on the bioavailability of two diltiazem formulations during repeated administrations in humans. Fund Clin Pharm 1: 67-75, 1987
26. Stone PH, Gibson RS, Glasser SR, De Wood MA, Parker JD, Kawanishi DT, Crawford MH, Messineo FC, Shook TL, Raby K: Comparison of propranolol, diltiazem and nifedipine in the treatment of ambulatory ischemia in patients with stable angina. Circulation 82: 1962-1972, 1990
27. Frischman W, Charlap S, Kimmel B, Teicher M, Cinnamon J, Allen L, Strom J: Diltiazem, nifedipine and their combination in patients with stable angina pectoris: Effects of angina, exercise tollerance and the ambulatory electrocardiographic ST segment. Circulation 77: 774-786, 1988
28. Theroux P, Baird M, Juneau M, Warnica W, Klinke P, Kostuk W, Pflugfelder P, Lavallee E, Chin C, Dempsey E: Effect of diltiazem on symptomatic and asymptomatic episodes of ST segment depression occurring daily life and during exercise. Circulation 84: 15-22, 1991