Amiodarone-an "old" drug with new recommendations

Current Opinion in Pediatrics

Volumn 15, Issue 2, 2003, Pages 193-199

  McKee, Michele R ^a  

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; AMINOPHYLLINE; AMIODARONE; ANTIARRHYTHMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BICARBONATE; CALCIUM CHANNEL BLOCKING AGENT; CATECHOLAMINE; CEFAZOLIN; CYCLOSPORIN; CYTOCHROME P450 3A; DIGOXIN; DISOPYRAMIDE; ENCAINIDE; FLECAINIDE; HEPARIN; LIDOCAINE; MEXILETINE; MEZLOCILLIN; PHENYTOIN; POTASSIUM CHANNEL BLOCKING AGENT; PROCAINAMIDE; PROPAFENONE; PROPRANOLOL; QUINIDINE; SODIUM CHANNEL BLOCKING AGENT; TOCAINIDE; UNINDEXED DRUG; VERAPAMIL; WARFARIN;

BRADYCARDIA; CARDIOVERSION; CLINICAL PRACTICE; CORNEA DISEASE; DRUG CLASSIFICATION; DRUG DISTRIBUTION; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG EXCRETION; DRUG INDICATION; DRUG INFORMATION; DRUG INFUSION; DRUG MECHANISM; DRUG METABOLISM; DRUG RESEARCH; DRUG UTILIZATION; FEVER; HEADACHE; HEART ARREST; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART ATRIUM FLUTTER; HEART BLOCK; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HUMAN; HYPOTENSION; HYPOTHYROIDISM; KERATOPATHY; LIVER TOXICITY; LUNG TOXICITY; NAUSEA; NEUROPATHY; PHLEBITIS; PHOTOSENSITIVITY; PRACTICE GUIDELINE; PRIORITY JOURNAL; QT INTERVAL; RASH; RESUSCITATION; REVIEW; SICK SINUS SYNDROME; SIDE EFFECT; SKIN DISCOLORATION; SUPRAVENTRICULAR TACHYCARDIA; THYROID DISEASE; TORSADE DES POINTES; WENCKEBACH PERIOD;

ACTION POTENTIALS; AMIODARONE; ANTI-ARRHYTHMIA AGENTS; CHILD; HEART CONDUCTION SYSTEM; HUMANS; TACHYCARDIA, ECTOPIC JUNCTIONAL; TACHYCARDIA, SUPRAVENTRICULAR;

EID: 0037376468     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008480-200304000-00010     Document Type: Review

References (33)

1. Coumel P, Fidelle J: Amiodarone in the treatment of cardiac arrhythmias in children: one hundred thirty-five cases. Am Heart J 1980, 100:1063-1069.
2. Garson A Jr, Gillette PC, McVey P, et al.: Amiodarone treatment of critical arrhythmias in children and young adults. J Am Coll Cardiol 1984, 4:749-755.
3. Costigan DC, Holland FJ, Daneman D, et al.: Amiodarone therapy effects on childhood thyroid function. Pediatrics 1986, 77:703-708.
4. Pongiglione G, Strasburger JF, Deal BJ, et al.: Use of amiodarone for short-term and adjuvant therapy in young patients. Am J Cardiol 1991, 68:603-608.
5. Perry JC, Knilans TK, Marlow D, et al.: Intravenous amiodarone for life-threatening tachyarrhythmias in children and young adults. J Am Coll Cardiol 1993, 22:95-98.
6. Figa FH, Gow RM, Hamilton RM, et al.: Clinical efficacy and safety of intravenous amiodarone in infants and children. Am J Cardiol 1994, 74:673-677.
7. Raja P, Hawker RE, Chaikitpinyo A, et al.: Amiodarone management of junctional ectopic tachycardia after cardiac surgery in children. Br Heart J 1994, 72:573-577.
8. Soult JA, Munoz M, Lopez JD, et al.: Efficacy and safety of intravenous amiodarone for short-term treatment of paroxysmal supraventricular tachycardia in children. Pediatr Cardiol 1995, 16:16-19.
9. Perry JC, Fenrich AL, Hulse JE, et al.: Pediatric use of intravenous amiodarone: efficacy and safety in critically ill patients from a multicenter protocol. J Am Coll Cardiol 1996, 27:1246-1250.
10. Etheridge SP, Judd VE: Supraventricular tachycardia in infancy: evaluation, management, and follow-up. Arch Pediatr Adolesc Med 1999, 153:267-271.
11. c without proarrhythmia.
12. Textbook of Pediatric Intensive Care. 3rd ed. Rogers MD, Nichols DG, eds. Baltimore, MD: Williams & Wilkins; 1996.
13. Clancy C: Electrocardiographic principles. In Goldfrank's Toxicologic Emergencies. 7th ed. Goldfrank LR, Flomenbaum NE, Lewin NA, et al., eds. New York, NY: McGraw-Hill; 2002:120.
14. Nattel S, Talajic M, Quantz M, et al.: Frequency-dependent effects of amiodarone on atrioventricular nodal function and slow-channel action potentials: evidence for calcium channel-blocking activity. Circulation 1987, 76:442-449.
15. Singh BN, Nademanee K: Amiodarone and thyroid function: clinical implications during antiarrhythmic therapy. Am Heart J 1983, 106:857-869.
16. Mitchell LB, Wyse DG, Gillis AM, et al.: Electropharmacology of amiodarone therapy initiation: time courses of onset of electrophysiologic and antiarrhythmic effects, Circulation 1989, 80:34-42.
17. Kadish AH, Chen RF, Schmaltz S, et al.: Magnitude and time course of beta-adrenergic antagonism during oral amiodarone therapy. J Am Coll Cardiol 1990, 16:1240-1245.
18. Rodenm DM: Pharmacokinetics of amiodarone: implications for drug therapy, Am J Cardiol 1993;72:45F-50F.
19. Polster P, Broekhuysen J: The adrenergic antagonism of amiodarone. Biochem Pharmacol 1976, 25:131-134.
20. AHFS Drug Information 2000 Amiodarone Hydrochloride. McEvoy GK, ed. Bethesda, MD: American Society of Health Syst Pharm, Inc; 2000:1446-1459.
21. Desai AD, Chun S, Sung RJ: The role of intravenous amiodarone in the management of cardiac arrhythmias. Ann Intern Med 1997, 127:294-303.
22. Kadish A, Morady F: The use of intravenous amiodarone in the acute therapy of life-threatening tachyarrhythmias. Prog Cardiovasc Dis 1989, 31:281-294.
23. Talajic M, DeRoode R, Nattel S: Comparative electrophysiologic effects of intravenous amiodarone and desethylamiodarone in dogs: evidence for clinically relevant activity of the metabolite. Circulation 1987, 75:265-271.
24. Scheinman MM, Levine JH, Cannom DS, et al.: Dose-ranging study of intravenous amiodarone in patients with life-threatening ventricular tachyarrhythmias. Circulation 1995, 92:3264-3272.
25. Levine JH, Massumi A, Scheinman MM, et al.: Intravenous amiodarone for recurrent sustained hypotensive ventricular tachyarrhythmias. The Intravenous Amiodarone Multicenter Trial Group. J Am Coll Cardiol 1995, 27:67-75.
26. Mooss AN, Mohiuddin SM, Hee TT, et al.: Efficacy and tolerance of high-dose intravenous amiodarone for recurrent, refractory ventricular tachycardia. Am J Cardiol 1990, 65:609-614.
27. Vanbesien J, Casteels A, Bougatef A, et al.: Transient fetal hypothyroidism due to direct fetal administration of amiodarone for drug resistant fetal tachycardia. Am J Perinatol 2001, 18:113-116. This case reported on two premature infants who received direct fetal administration of amiodarone for SVT. It emphasized interaction with the thyroid axis: premature infants in the region of mild iodine insufficiency may require L-thyroxine therapy for hypothyroidism. Previous perinatal studies addressed similar concerns; however, the route of exposure was through maternal treatment.
28. Daniels CJ, Schuette DA, Hammond S, et al.: Acute pulmonary toxicity in an infant from intravenous amiodarone. Am J Cardiol 1997, 80:1113-1116.
29. Bowers PN, Fields J, Schwartz D, et al.: Amiodarone induced pulmonary fibrosis in infancy. Pacing Clin Electrophysiol 1998, 21:1665-1667.
30. Kothari SS, Banlijepally S, Taneja K: Amiodarone-induced pulmonary toxicity in an adolescent. Cardiol Young 1999, 9:194-196.
31. Luedtke SA, Kuhn RJ, McCaffrey FM: Pharmacologic management of supraventricular tachycardia in children. Part 2: Atrial flutter, atrial fibrillation and junctional and atrial ectopic tachycardia. Ann Pharmacother 1997, 31:1347-1359.
32. Thomson Micromedex Healthcare Series Integrated Index (computer software database). Vol 14. 2002.
33. Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Part 10: pediatric advanced life support. The American Heart Association in collaboration with the International Liaison Committee on Resuscitation. Circulation 2000, 102(suppl 8):1291-1342.