Specificity of the rat vesicular acetylcholine transporter

Neurochemical Research

Volumn 28, Issue 3-4, 2003, Pages 473-476

  Kim, Myung Hee ^a   Lu, Mei ^a   Rogers, Gary ^b   Parsons, Stanley ^b   Hersh, Louis B ^a,c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Acetylcholine analogs; Acetylcholine transport; Inhibition; Kinetics; Vesamicol binding; Vesicular acetylcholine transporter

Indexed keywords

ACETYLCHOLINE DERIVATIVE; CHOLINE ACETYLTRANSFERASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; VESAMICOL; VESICULAR ACETYLCHOLINE TRANSPORTER;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL LINE; CONTROLLED STUDY; ENZYME DEFICIENCY; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; SYNAPSE VESICLE;

ACETYLCHOLINE; ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; MEMBRANE TRANSPORT PROTEINS; PC12 CELLS; PIPERIDINES; RATS; SYNAPTIC VESICLES; VESICULAR ACETYLCHOLINE TRANSPORT PROTEINS; VESICULAR TRANSPORT PROTEINS;

ANIMALIA; MAMMALIA; TORPEDO;

EID: 0037375882     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022804903088     Document Type: Article

References (13)

1. Parsons, S. M., Prior, C., and Marshall, I. G. 1993. Acetylcholine transport, storage, and release. Int. Rev. Neurobiol. 35:279-389.
2. Usdin, T. B., Eiden, L. E., Bonner, T. I., and Erickson, J. D. 1995. Molecular biology of the vesicular ACh transporter. Trends Neurosci. 18:218-224.
3. Bahr, B. A. and Parsons, S. M. 1986. Acetylcholine transport and drug inhibition kinetics in Torpedo synaptic vesicles. J. Neurochem. 46:1214-1218.
4. Bahr, B. A. and Parsons, S. M. 1986. Demonstration of a receptor in Torpedo synaptic vesicles for the acetylcholine storage blocker L-trans-2-(4-phenyl[3,4-3H]-piperidino) cyclohexanol. Proc. Natl. Acad. Sci. USA 83:2267-2270.
5. Bahr, B., Clarkson, E. D., Rogers, G. A., Noremberg, K., and Parsons, S. M. 1992. A kinetic and allosteric model for the acetylcholine transporter-vesamicol receptor in synaptic vesicles. Biochemistry 31:5752-5762.
6. Diebler, M.-F. and Morot Gaudry-Talarmain, Y. 1989. AH5183 and cetiedil: Two potent inhibitors of acetylcholine uptake into isolated synaptic vesicles from Torpedo marmorata. J. Neurochem. 52:813-821.
7. Kim, M. H., Lu, M., Lim, E. J., Chai. Y. G., and Hersh, L. B. 1999. Mutational analysis of aspartate residues in the transmembrane regions and cytoplasmic loops of rat vesicular acetylcholine transporter. J. Biol. Chem. 274:673-680.
8. Kim, M. H., Lu, M., Kelly, M. Hersh, L. B. 2000. Mutational analysis of basic residues in the rat vesicular acetylcholine transporter: Identification of a transmembrane ion pair and evidence that histidine is not involved in proton translocation. J. Biol. Chem. 275:6175-6180.
9. Rogers, A. and Parsons, S. M. 1989. Inhibition of acetylcholine storage by acetylcholine analogs in vitro. Mol. Pharmacol. 36:333-341.
10. Clarkson, E. D., Rogers, A., and Parsons, S. M. 1992. Binding and active transport of large analogues of acetylcholine by cholinergic synaptic vesicles in vitro. J. Neurochem. 59:695-700.
11. Ginty, D. D., Glowacka, D., Defranco, C., and Wagner, J. A. 1991. Nerve growth factor-induced neuronal differentiation after dominant repression of both type I and type II cAMP-dependent protein kinase activities. J. Biol. Chem. 266:15325-15333.
12. Inoue, H., Li, Y-P., Wagner, J. A., and Hersh, L. B. 1995. Expression of the choline acetyltransferase gene depends on protein kinase A activity. J. Neurochem. 64:985-990.
13. Shimojo, M., Wu, D., and Hersh, L. B. 1998. The cholinergic gene locus (choline acetyltransferase and acetylcholine transporter genes) is coordinately regulated by protein kinase A II. J. Neurochem. 71:1118-1126.