Tigliane diterpenes from the latex of Euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain

Journal of Ethnopharmacology

Volumn 85, Issue 2-3, 2003, Pages 279-282

  Betancur Galvis, Liliana ^a   Palomares, Emilio ^b   Marco, J Alberto ^b   Estornell, Ernesto ^b  

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Antitumor compounds; Euphorbia obtusifolia; Euphorbiaceae; Mitochondrial respiratory chain; Tigliane diterpenes

Indexed keywords

4,20 DIDEOXYPHORBOL 12,13 BIS(ISOBUTYRATE); EUPHORBIA OBTUSIFOLIA EXTRACT; PLANT EXTRACT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; TERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BEEF CATTLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG ISOLATION; DRUG MECHANISM; ENZYME INHIBITION; EUPHORBIA OBTUSIFOLIA; HEART; IC 50; MEDICINAL PLANT; MITOCHONDRIAL RESPIRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EUPHORBIA OBTUSIFOLIA;

EID: 0037375182     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(03)00010-2     Document Type: Article

References (17)

1. Bernal, H.Y., Correa, J.E., 1990. Especies Vegetales Promisorias de los Países del Convenio Andrés Bello. Tomo VII, Talleres de Editora Guadalupe Ltda, Bogotá D.E., p. 480.
2. Betancur-Galvis L., Sáez J., Granados H., Salazar A., Ossa J. Antitumor and antiviral activity of Colombian medicinal plant extracts. Memórias do Instituto Oswaldo Cruz. 94:1999;531-535.
3. Degli E.M., Ghelli A., Ratta M., Cortes D., Estornell E. Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I). Biochemical Journal. 301:1994;161-167.
4. Evans F.L.S., Fred J., Edwards M.C. Activity correlations in the phorbol ester series. Botanical Journal of the Linnean Society. 94:1987;231-246.
5. Fatope M.O., Zeng L., Ohayaga J.E., Shi G., McLaughlin J.L. Selective cytotoxic diterpenes from Euphorbia poisonii. Journal of Medicinal Chemistry. 39:1996;1005-1008.
6. Garcia-Barriga, H., 1974. Flora medicinal de Colombia. Botánica Médica, 2nd ed. Universidad Nacional de Colombia, Talleres editoriales de la Imprenta Nacional, Santa Fé de Bogotá, D.C., p. 562.
7. Itokawa H., Ichihara Y., Watanabe K., Takeya K. An antitumor principle from Euphorbia lathyris. Planta Medica. 55:1989;271-272.
8. Kahl A. La función del médico en estudios etnobotánicos in situ. Ciencia y Tecnología. 14:1996;3-11.
9. Marco J.A., Sanz-Cervera J.F., Checa J., Palomares E., Fraga B.M. Jatrophane and tigliane diterpenes from the latex of Euphorbia obtusifolia. Phytochemistry. 52:1999;479-485.
10. Morre D.J., De Cabo R., Farley C., Oberlies N.H., McLaughlin J.L. Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes. Life Sciences. 56:1995;343-348.
11. Müller W., Schewe T., Rapoport S. Electron transport particles from beef-heart mitochondria as a test system for inhibitors of the respiratory chain. Acta Biologica et Medica Germanica. 36:1977;941-960.
12. Noack E.A., Crea A.E., Falsone G. Inhibition of mitochondrial oxidative phosporylation by 4-deoxyphorbol triester, a poisonous constituent of the latex of Euphorbia biglandulosa Desf. Toxicon. 18:1980;165-174.
13. Piñeros, J., Garcia-Barriga, H., Irequi, A., Prias, E., Perdomo, C., Pueta, H.F., 1992. Plantas Medicinales, Compendio de Farmacología Vegetal. 2nd ed. Escuela de Medicina Juan N. Corpa, Fondo Editorial Universitario, Santa Fé de Bogotá.
14. Przybyszewski J., Box H.C., Kulesz-Martin M. Induction of reactive oxygen species without 8-hydroxydeoxyguanosine formation in DNA of initiated mouse keratinocytes treated with 12-O-tetradecanoylphorbol-13-acetate. Carcinogenesis. 19:1998;1467-1474.
15. Tormo J.R., Estornell E., Gallardo T., Gonzalez M.C., Cave A., Granell S., Cortes D., Zafra-Polo M.C. Gamma-lactone-functionalized antitumor acetogenins are the most potent inhibitors of mitochondrial complex I. Bioorganic and Medicinal Chemical Letters. 11:2001;681-684.
16. Vasquez, M.L., 1982. Euphorbia lathyris. Plantas y Frutas Medicinales de Colombia y America. Editorial Climent, Cali-Colombia, p. 245.
17. Wu T.S., Lin Y.M., Haruna M., Pan D.J., Shingu T., Chen Y.P., Hsu H.Y., Nakano T., Lee K.H. Antitumor agents, 119. Kansuiphorins A and B, two novel antileukemic diterpene esters from Euphorbia kansui. Journal of Natural Products. 54:1991;823-829.