Monoclonal anti-idiotype antibodies recognizing the variable region of a high-affinity antibody against 11-deoxycortisol. Production, characterization and application to a sensitive noncompetitive immunoassay

Journal of Immunological Methods

Volumn 274, Issue 1-2, 2003, Pages 63-75

  Kobayashi, Norihiro ^a,b   Shibusawa, Kazuki ^a   Kubota, Kazuyuki ^a   Hasegawa, Noriko ^a   Sun, Pi ^a   Niwa, Toshifumi ^a   Goto, Junichi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

11 Deoxycortisol; Anti idiotype antibody; ELISA; Hapten; Monoclonal antibody; Noncompetitive immunoassay

Indexed keywords

ANTIBODY CONJUGATE; ANTIIDIOTYPIC ANTIBODY; CORTODOXONE; HAPTEN ANTIBODY; HORMONE ANTIBODY; KEYHOLE LIMPET HEMOCYANIN; MONOCLONAL ANTIBODY;

ACCURACY; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ARTICLE; BLOOD CELL COUNT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FUNCTIONAL ASSESSMENT; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; IMMUNIZATION; MALE; MOUSE; MOUSE STRAIN; MYELOMA CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

ANIMALS; ANTIBODIES; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; CORTODOXONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HAPTENS; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, INBRED BALB C; SENSITIVITY AND SPECIFICITY;

EID: 0037373587     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(02)00501-X     Document Type: Article

References (28)

1. Barnard G., Kohen F. Idiometric assay: noncompetitive immunoassay for small molecules typified by the measurement of estradiol in serum. Clin. Chem. 36:1990;1945.
2. Barnard G., Amir-Zaltsman Y., Lichter S., Gayer B., Kohen F. The measurement of oestrone-3-glucuronide in urine by non-competitive idiometric assay. J. Steroid Biochem. Mol. Biol. 55:1995;107.
3. Barnard G., Osher J., Lichter S., Gayer B., De Boever J., Limor R., Ayalon D., Kohen F. The measurement of progesterone in serum by a non-competitive idiometric assay. Steroids. 60:1995;824.
4. Berson S., Yalow R.S. Quantitative aspects of the reaction between insulin and insulin-binding antibody. J. Clin. Invest. 38:1959;1996.
5. Coulter A., Harris R. Simplified preparation of rabbit Fab fragments. J. Immunol. Methods. 59:1983;199.
6. Ekins R. More sensitive immunoassays. Nature. 284:1980;14.
7. Grassi J., Créminon C., Frobert Y., Etienne E., Ezan E., Volland H., Pradelles P. Two different approaches for developing immunometric assays of haptens. Clin. Chem. 42:1996;1532.
8. Hill M., Lapčík O., Hampl R., Stárka L., Putz Z. Radioimmunoassay of three deoxycorticosteroids in human plasma following HPLC separation. Steroids. 60:1995;615.
9. Hosoda H., Miyairi S., Kobayashi N., Nambara T. Radioimmunoassay of 11-deoxycortisol. Specificity of antisera raised against 11-deoxycortisol-[C-4]-bovine serum albumin conjugates. Chem. Pharm. Bull. 30:1982;2127.
10. Hosoda H., Kobayashi N., Miyairi S., Kato A., Kawamoto H., Nambara T. Enzyme immunoassay for plasma 11-deoxycortisol. Application to metyrapone test. Chem. Pharm. Bull. 32:1984;3594.
11. Hosoda H., Kobayashi N., Tamura S., Mitsuma M., Sawada J., Terao T., Nambara T. Production and specificity of a monoclonal anti-11-deoxycortisol antibody. Chem. Pharm. Bull. 34:1986;2914.
12. Hosoda H., Tamura S., Tsukamoto R., Kobayashi N., Sawada J., Terao T., Nambara T. An enzyme immunoassay system with a monoclonal antibody for the determination of 11-deoxycortisol. Chem. Pharm. Bull. 35:1987;1497.
13. Ishikawa E., Hashida S., Kohno T., Hirota K. Ultrasensitive enzyme immunoassay. Clin. Chim. Acta. 194:1990;51.
14. 3+ chelates as non-radioisotopic tracers. J. Immunol. Methods. 87:1986;13.
15. Jerne N.K., Roland J., Cazenave P.-A. Recurrent idiotopes and internal images. EMBO J. 1:1982;243.
16. Kobayashi N., Goto J. Noncompetitive immunoassays for small molecules with high sensitivity and specificity. Adv. Clin. Chem. 36:2001;139.
17. 3 conjugated with bovine serum albumin through the C-3 or C-24 position. Biol. Pharm. Bull. 29:1997;948.
18. Kobayashi N., Oiwa H., Goto J. Production and characterization of group-specific monoclonal antibodies recognizing nonamidated, glycine- and taurine-amidated ursodeoxycholic acid 7-N-acetylglucosaminides. J. Steroid Biochem. Mol. Biol. 64:1998;171.
19. Kobayashi N., Katsumata H., Katayama H., Oiwa H., Goto J., Takeuchi Y. A monoclonal antibody-based enzyme-linked immunosorbent assay of ursodeoxycholic acid 3-sulfates in human urine. J. Steroid Biochem. Mol. Biol. 72:2000;265.
20. Kobayashi N., Oiwa H., Kubota K., Sakoda S., Goto J. Monoclonal antibodies generated against an affinity-labeled immune complex of an anti-bile acid metabolite antibody: an approach to noncompetitive hapten immunoassays based on anti-idiotype or anti-metatype antibodies. J. Immunol. Methods. 245:2000;95.
21. Kobayashi N., Shibahara K., Ikegashira K., Shibusawa K., Goto J. Single-chain Fv fragments derived from an anti-11-deoxycortisol antibody. Affinity, specificity, and idiotype analysis. Steroids. 67:2002;733.
22. Köhler G., Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 256:1975;495.
23. Kussie P.H., Albright G., Linthicum D.S. Production and characterization of monoclonal idiotypes and anti-idiotypes for small ligands. Methods Enzymol. 178:1989;49.
24. Liddle G.W., Estep H.L., Kendall J.W. Jr., Williams W.C. Jr., Townes A.W. Clinical application of a new test of pituitary reserve. J. Clin. Endocrinol. Metab. 19:1959;875.
25. Sawada J., Janejai N., Terao T. Production and characterization of monoclonal and polyclonal antibodies against digoxin. Bull. Natl. Inst. Health Sci. 108:1990;29.
26. Self, C.H., 1989. Determination method, use and components. World Intellectual Property Organization International Publication no. WO89/05453.
27. Spiger M., Jubiz W., Meikle A.W., West C.D., Tylor F.H. Single-dose metyrapone test: review of a four-year experience. Arch. Intern. Med. 135:1975;698.
28. Ueshiba H., Sagawa M., Hayashi T., Miyachi Y., Irie M. Serum profiles of steroid hormones in patients with Cushing's syndrome determined by a new HPLC/RIA method. Clin. Chem. 37:1991;1329.