Calcium and the heart: A question of life and death

Journal of Clinical Investigation

Volumn 111, Issue 5, 2003, Pages 597-600

  Marks, Andrew R ^a  

^a Columbia Univ Coll of Phys/Surg ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; CALCINEURIN; CALCIUM; CATECHOLAMINE; CONTRACTILE PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; INTERLEUKIN 2; ISOPRENALINE; PROTEIN KINASE (CALCIUM,CALMODULIN); T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR NFAT;

CALCIUM TRANSPORT; HEART; HEART CONTRACTION; HEART FAILURE; HEART HYPERTROPHY; HUMAN; NOTE; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM;

EID: 0037371697     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI18067     Document Type: Note

References (7)

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2. Marks, A.R., Reiken, S., and Marx, S.O. 2002. Progression of heart failure: is protein kinase a hyperphosphorylation of the ryanodine receptor a contributing factor? Circulation. 105:272-275.
3. Chidsey, C.A., Harrison, D.C., and Braunwald, E. 1962. Augmentation of plasma norepinephrine response to exercise in patients with congestive heart failure. N. Engl. J. Med. 267:650.
4. Marx, S.O., et al. 2000. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell. 101:365-376.
5. 1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2-/calmodulin kinase II. J. Clin. Invest. 111:617-625. doi:10.1172/JCI200316326.
6. Luttrell, L.M., et al. 1999. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 283:655-661.
7. Zaccolo, M., Magalhaes, P., and Pozzan, T. 2002. Compartmentalisation of cAMP and Ca(2+) signals. Curr. Opin. Cell. Biol. 14:160-166.