Suppression of hypothalamic pro-opiomelanocortin (POMC) gene expression by daily melatonin supplementation in aging rats

Journal of Pineal Research

Volumn 34, Issue 2, 2003, Pages 127-133

  Rasmussen, Dennis D ^a,c   Marck, Brett T ^a   Boldt, Brian M ^a   Yellon, Steven M ^b   Matsumoto, Alvin M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

Author keywords

Aging; Gene expression; Hypothalamus; Melatonin; mRNA; POMC; Proopiomelanocortin

Indexed keywords

DRINKING WATER; ESTRADIOL; MELATONIN; MESSENGER RNA; PROOPIOMELANOCORTIN; TESTOSTERONE;

AGING; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; ESTRADIOL BLOOD LEVEL; FEMALE; FOREBRAIN; GENE EXPRESSION; HYPOTHALAMUS; MALE; NONHUMAN; PRECURSOR; RAT; RAT STRAIN; TESTOSTERONE BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

AGING; ANIMALS; BODY WEIGHT; GENE EXPRESSION REGULATION; IN SITU HYBRIDIZATION; MALE; MELATONIN; PRO-OPIOMELANOCORTIN; RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 0037371450     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-079X.2003.00019.x     Document Type: Article

References (35)

1. CAGNACCI A. Melatonin in relation to physiology in adult humans. J Pineal Res 1996; 21:200-213.
2. REITER R. The ageing pineal gland and its physiological consequences. Bioessays 1992; 14:169-175.
3. REITER R, TANG L, GARCIA JJ et al. Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sci 1997; 60:2255-2271.
4. PANG SF, TSANG CW, HONG GX et al. Fluctuation of blood melatonin concentrations with age: result of changes in pineal melatonin secretion, body growth, and aging. J Pineal Res 1990; 8:179-192.
5. RASMUSSEN DD, MITTON DR, LARSEN SA et al. Aging-dependent changes in the effect of daily melatonin supplementation on rat metabolic and behavioral responses. J Pineal Res 2001; 31:89-94.
6. RASMUSSEN DD, BOLDT BM, WILKINSON CW et al. Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels. Endocrinology 1999; 140:1009-1012.
7. WOLDEN-HANSON T, MITTON DR, MCCANTS RL et al. Daily melatonin administration to middle-aged male rats suppresses body weight, intra-abdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat. Endocrinology 2000; 141:487-497.
8. ABEL TW, RANCE NE. Proopiomelanocortin gene expression is decreased in the infundibular nucleus of postmenopausal women. Mol Brain Res 1999; 69:202-208.
9. GRUENEWALD DA, MATSUMOTO AM. Age-related decrease in proopiomelanocortin gene expression in the arcuate nucleus of the male rat brain. Neurobiol Aging 1991; 12:113-121.
10. NELSON JF, BENDER M, SCHACHTER BS. Age-related changes in proopiomelanocortin messenger ribonucleic acid levels in hypothalamus and pituitary of female C57BL/6J mice. Endocrinology 1988; 123:340-344.
11. MOUNTJOY KG, WONG J. Obesity, diabetes and function for proopiomelanocortin-derived peptides. Mol Cell Endocrinol 1997; 128:171-177.
12. TRENTINI GP, GENAZZANI AR, CRISCUOLO M et al. Melatonin treatment delays reproductive aging of female rat via the opiatergic system. Neuroendocrinology 1992; 56:364-370.
13. RASMUSSEN DD. The interaction between mediobasohypothalamic dopaminergic and endorphinergic neuronal systems as a key regulator of reproduction: an hypothesis. J Endocrinol Invest 1991; 14:323-352.
14. OAKNIN-BENDAHAN S, ANIS Y, NIR I et al. Effects of long-term administration of melatonin and a putative antagonist on the ageing rat. Neuroreport 1995; 6:785-788.
15. PAXINOS G, WATSON C. The rat brain in stereotoxic coordinates, Academic Press, Inc., San Diego, 1986.
16. RASMUSSEN DD, JAKUBOWSKI M, ALLEN DL et al. Positive correlation between proopiomelanocortin and tyrosine hydroxylase mRNA levels in the mediobasohypothalamus of ovariectomized rats: response to estradiol replacement and withdrawal. Neuroendocrinology 1992; 56:285-294.
17. YELLON SM, HILLIKER S. Influence of acute melatonin treatment and light on the circadian melatonin rhythm in the Djungarian hamster. J Biol Rhythm 1994; 9:71-81.
18. JAMALI KA, TRAMU G. Control of rat hypothalamic proopiomelanocortin neurons by a circadian clock that is entrained by the daily light-off signal. Neuroscience 1999; 93:1051-1061.
19. GENAZZANI AR, De Ramundo BM, Criscuolo M et al. Acetyl-1-carnitine restores the daily pattern of hypothalamic b-endorphin in rats exposed to continuous light. Eur J Pharmacol 1990; 186:177-180.
20. STEINER RA, KABIGTING E, LENT K et al. Diurnal rhythm in proopiomelanocortin mRNA in the arcuate nucleus of the male rat. J Neuroendocrinol 1994; 6:603-608.
21. BARRETT T, KENT S, VOUDOURIS N. Does melatonin modulate beta-endorphin, corticosterone, and pain threshold? Life Sci 1999; 66:467-476.
22. BONDARENKO LO. The comparative evaluation of the effect of the season on the formation of a nighttime melatonin peak in young sexually mature and old rats. Fiziol Zh 1992; 38: 111-114.
23. REITER RJ, CRAFT CM, JOHNSON JEJ et al. Age-associated reduction in nocturnal pineal melatonin levels in female rats. Endocrinology 1981; 109:1295-1297.
24. REUSS S, OLCESE J, VOLLRATH L. Electrophysiological and endorinological aspects of aging in the pineal gland. Neuroendocrinology 1986; 43:466-470.
25. SELMAOUI B, TOUITOU Y. Age-related differences in serum melatonin and pineal NAT activity and in the response of rat pineal to a 50-Hz magnetic field. Life Sci 1999; 64:2291-2297.
26. WEILAND NG, SCARBROUGH K, WISE PM. Aging abolishes the estradiol-induced suppression and diurnal rhythm of proopiomelanocortin gene expression in the arcuate nucleus. Endocrinology 1992; 131:2959-2964.
27. SCARBROUGH K, JAKUBOWSKI M, LEVIN N et al. The effect of time of day on levels of hypothalamic proopiomelanocortin primary transcript, processing intermediate and messenger ribonucleic acid in proestrous and estrous rats. Endocrinology 1994; 134:555-561.
28. LLOYD JM, SCARBROUGH K, WEILAND NG et al. Age-related changes in proopiomelanocortin (POMC) gene expression in the periarcuate region of ovariectomized rats. Endocrinology 1991; 129:1896-1902.
29. 3H]flunitrazepam binding through an opioid mechanism. Neurosci Lett 1993; 164:149-153.
30. BITTMAN EL, TUBBIOLA ML, FOLTZ G et al. Effects of photoperiod and androgen on proopiomelanocortin gene expression in the arcuate nucleus of golden hamsters. Endocrinology 1999; 140:197-206.
31. MERCER JG, MOAR KM, ROSS AW et al. Photoperiod regulates arcuate nucleus POMC, AGRP, and leptin receptor mRNA in Siberian hamster hypothalamus. Am J Physiol Regul Integr Comp Physiol 2000; 278:R271-R278.
32. PANG SF, TSANG CW, HONG GX et al. Fluctuation of blood melatonin concentrations with age: result of changes in pineal melatonin secretion, body growth, and aging. J Pineal Res 1990; 8:179-192.
33. CHEUNG CC, CLIFTON DK, STEINER RA. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 1997; 138:4489-4492.
34. SCHWARTZ MW, SEELEY RJ, WOODS SC et al. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 1997; 46:2119-2123.
35. TERZOLO M, PIOVESAN A, PULIGHEDDU B et al. Effects of longterm, low-dose, time-specified melatonin administration on endocrine and cardiovascular variables in adult men. J Pineal Res 1990; 9:113-124.