Alginate-diltiazem hydrocloride beads: Optimization of formulation factors, in vitro and in vivo availability

Journal of Microencapsulation

Volumn 20, Issue 2, 2003, Pages 211-225

  El Kamel, A H ^a   Al Gohary, O M N ^a   Hosny, E A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Alginate beads; Diltiazem hydrochloride; Formulation factors; In vitro and in vivo availability; Microencapsulation

Indexed keywords

ALGINIC ACID; AMITRIPTYLINE; BENZOTHIAZEPINE DERIVATIVE; CALCIUM ANTAGONIST; CALCIUM CHLORIDE; DILTIAZEM; DILZEM SR; DRUG ADDITIVE; GELATIN; METHYLCELLULOSE; PECTIN; POLYMER; CALCIUM; CARDIOVASCULAR AGENT; MICROSPHERE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; BIOEQUIVALENCE; CALCIUM ANTAGONISM; CONCENTRATION RESPONSE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DISPERSION; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG FORMULATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG RELEASE; GELATION; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; MEAN RESIDENCE TIME; METHODOLOGY; NONHUMAN; PH; POWDER; REVIEW; SUSTAINED RELEASE PREPARATION; TABLET; THERMAL ANALYSIS; ANIMAL; ARTICLE; BIOAVAILABILITY; CHEMISTRY; DELAYED RELEASE FORMULATION; DIFFUSION; GEL; TIME;

ALGINATES; ANIMALS; BIOLOGICAL AVAILABILITY; CALCIUM; CALCIUM CHLORIDE; CARDIOVASCULAR AGENTS; DELAYED-ACTION PREPARATIONS; DIFFUSION; DILTIAZEM; DOGS; DRUG COMPOUNDING; GELS; HYDROGEN-ION CONCENTRATION; METHYLCELLULOSE; MICROSPHERES; TABLETS; TIME FACTORS;

EID: 0037370868     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.1080/02652040210162568     Document Type: Review

References (24)

1. AHFS DRUG INFORMATION, 1997, American society of health system, pp. 1226-1231.
2. ASLANI, P. and KENNEDY, R. A., 1996, Studies on diffusion in alginate gels. I. Effects of cross-linking with calcium or zinc ions on diffusion of acetaminophen. Journal of Controlled Release, 42, 75-82.
3. BADWAN, A. A., ABUMALOOH, A., ALLAM, A., ABUKALAF, A. and JAWAN, O., 1985, A sustained release drug delivery system using calcium alginate beads. Drug Development and Industrial Pharmacy, 11, 239-256.
4. CHAN, L. W., HENG, P. W. and WAN, L. S., 1997, Effect of cellulose derivatives on alginate microspheres prepared by emulsification. Journal of Microencapsulation, 14, 545-555.
5. EL-KAMEL, A. H., SOKAR, M. S., AL GAMAL, S. S. and NAGGAR, V. F., 2001, Preparation and evaluation of ketoprofen floating oral delivery system. International Journal of Pharmaceutics, 220, 13-21.
6. GIBALDI, M., 1991, Compartmental and noncompartmental pharmacokinetics. In Biopharmaceutics and clinical pharmacokinetics (Philadelphia: Lea & Febiger), pp. 14-23.
7. HARI, P. R., CHANDY, T. and SHARMA, C. P., 1996, Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin. Journal of Microencapsulation, 13, 319-329.
8. IMAI, T., KAWASAKI, C., NISHIYAMA, T. and OTAGIRI, M., 2000, Comparison of the pharmaceutical properties of sustained-release gel beads prepared by alginate having different molecular size with commercial sustained-release tablets. Pharmazie, 55, 218-222.
9. KIM, H. and FASSIHI, R., 1997, A new ternary polymeric matrix system for controlled drug delivery of highly soluble drugs: 1-Diltiazem hydrochloride. Pharmaceutical Research, 14, 1415-1421.
10. LAPIDUS, H. and LORDI, N. G., 1966, Some factors affecting the release of a water soluble drug from a compressed hydrophilic matrix. Journal of Pharmaceutical Science, 55, 840-843.
11. LIU, L. S., LIU, S. Q., NG, S. Y., FROIX, M., OHNO, T. and HELLER, J., 1997, Controlled release of interleukin-2 for tumour immunotherapy using alginate/chitosan porous microspheres. Journal of Controlled Release, 43, 65-74.
12. MIRGHANI, A., IDKAIDEK, N. M., SALEM, M. S. and NAJIB, N. M., 2000, Formulation and release behavior of diclofenac sodium in compritol 888 matrix beads encapsulated in alginate. Drug Development and Industrial Pharmaceutics, 26, 791-795.
13. OSTBERG, T., LUND, M. E. and GRAFFNER, C., 1994, Calcium alginate matrices for oral multiple unit administration: IV. Release characteristics in different media. International Journal of Pharmaceutics, 112, 241-248.
14. PEPPAS, N. A., 1985, Analysis of Fickian and non-Fickian drug release from polymer. Pharma Acta Helvetia, 60, 110-111.
15. PEPPERMAN, A. B., KUAN, C. W. and MCCOMBS, C., 1991, Alginate controlled release formulations of metribuzin. Journal of Controlled Release, 17, 105-112.
16. PILLAY, V. and FASSIHI, R., 1999a, In vitro release modulation from crosslinked pellets for site-specific drug delivery to the gastrointestinal tract. I. Comparison of pH-responsive drug release and associated kinetics. Journal of Controlled Release, 59, 229-242.
17. PILLAY, V. and FASSIHI, R., 1999b, In vitro release modulation from crosslinked pellets for site-specific drug delivery to the gastrointestinal tract. II. Physicochemical characterization of calcium-alginate, calcium-pectinate and calcium-alginate-pectinate pellets. Journal of Controlled Release, 59, 243-256.
18. PILLAY, V., DANGOR, C. M., GOVENDER, T., MOOPANAR, K. R. and HURBAN, S. N., 1998, Ionotropic gelation: encapsulation of indomethacin in calcium alginate gel discs. Journal of Micoencapsulation, 15, 215-226.
19. RITGER, P. L. and PEPPAS, N. A., 1987, A simple equation for description of solute release II. Fickian and anomalous release from swellable device. Journal of Controlled Release, 5, 37-42.
20. SHIRAISHI, S., IMAI, T. and OTAGIRI, M., 1993, Controlled-release preparation of indomethacin using calcium alginate gel. Biological and Pharmaceutical Bulletin, 16, 1164-1168.
21. SWARBRICK, J. and BOYLAN, J. C., 1992, Gel and jellies. In Encyclopedia of pharmaceutical technology, vol 6 (New York: Marcel Dekker), pp. 415-439.
22. TAKKA, S., OCAK, Ö.H. and ACARTURK, F., 1998, Formulation and investigation of nicardipine HCl-alginate gel beads with factorial design-based studies. European Journal of Pharmaceutical Science, 6, 241-246.
23. TURKOGLU, M., GURSAY, A., EROGLU, L. and OKAR, I., 1997, Effect of aqueous polymer dispersions on properties of diclofenac/alginate beads and in vivo evaluation in rats. STP Pharma Sciences, 7, 135-140.
24. YOTSUYANAGI, T., OHKUBO, T., OHHASHI, T. and IKEDA, K., 1987, Calcium-induced delation of alginic acid and pH-sensitive reswelling of dried gels. Chemical and Pharmaceutical Bulletin, 34, 1555-1563.