Notochord anomalies in the adriamycin rat model: A morphologic and molecular basis for the VACTERL association

Journal of Pediatric Surgery

Volumn 38, Issue 3, 2003, Pages 469-473

  Gillick, J ^a   Mooney, E ^a   Giles, S ^a   Bannigan, J ^a   Puri, Prem ^a,b   Gittes, G ^c  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b OUR LADY S CHILDREN S HOSPITAL   (Ireland)

^c NONE

Author keywords

Adriamycin rat; Notochord; Sonic hedgehog

Indexed keywords

DOXORUBICIN; SONIC HEDGEHOG PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONGENITAL MALFORMATION; CONTROLLED STUDY; EMBRYO; EMBRYO PATTERN FORMATION; FEMALE; IN SITU HYBRIDIZATION; KIDNEY DEVELOPMENT; MIDGUT; MORPHOLOGY; NONHUMAN; NOTOCHORD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

EID: 0037370414     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1053/jpsu.2003.50081     Document Type: Conference Paper

References (24)

1. Ding Q, Motoyama J, Gasca S, et al: Diminished Sonic hedgehog signalling and lack of floor plate differentiation in Gli2 mutant mice. Development 125:2533-2543, 1998
2. Echelard Y, Epstein DJ, St-Jacques B, et al: Sonic hedgehog, a member of a family of putative signalling molecules, is implicated in the regulation of CNS polarity. Cell 75:1417-1430, 1993
3. Bitgood MJ, McMahon AP: Hedgehog and Bmp genes are co expressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol 172:126-138, 1995
4. Apelqvist A, Ahlgren U, Edlund H: Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr Biol 7:801-804, 1997
5. Sukegawa A, Narita T, Kameda T, et al: The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium. Development 127:1971-1980, 2000
6. Bumcrot DA, McMahon AP: Somite differentiation. Sonic signals somites. Curr Biol 5:612-614, 1995
7. Kim SK, Hebrok M, Melton DA: Notochord to endoderm signalling is required for pancreas development. Development 124:4243-4252, 1997
8. Bumcrot DA, McMahon AP: Sonic hedgehog: Making the gradient. Chem Biol 3:13-16, 1996
9. Litingtung Y, Lei L, Westphal H, et al: Sonic hedgehog is essential to foregut development. Nat Genet 20:58-61, 1998
10. Motoyama J, Liu J, Mo R, et al: Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet 20:54-57, 1998
11. Kim PC, Mo R, Hui CC: Murine models of VACTERL syndrome: Role of sonic hedgehog signalling pathway. J Pediatr Surg 36:381-384, 2001
12. Kim J, Kim P, Hui CC: The VACTERL association: Lessons from the Sonic hedgehog pathway. Clin Genet 59:306-315, 2001
13. Orford J, Manglick P, Cass DT, et al: Mechanisms for the development of esophageal atresia. J Pediatr Surg 36:985-994, 2001
14. Gillick J, Giles JJ, Bannigan J, et al: Midgut atresias result from abnormal development of the notochord in the Adriamycin-rat model J Pediatr Surg 37:719-722, 2002
15. Gillick J, Giles JJ, Bannigan J, et al: Cell death in the early Adriamycin rat model. Pediat Surg Int 18:576-580, 2002
16. Wilkinson D: in Rickwood HB (ed): In Situ Hybridisation: A Practical Approach (ed 1). The Practical Approach Series, vol 109. Oxford, England, Oxford University Press, 1992
17. Correia KM, Conlon RA: Whole-mount in situ hybridization to mouse embryos. Methods 23:335-338, 2001
18. Roberts DJ, Smith DM, Goff DJ, et al: Epithelial-mesenchymal signalling during the regionalization of the chick gut. Development 125:2791-2801, 1998
19. Johnson RL, Tabin C. The long and short of hedgehog signalling. Cell 81:313-316, 1995
20. Wolpert L: Vertebrate limb development and malformations. Pediatr Res 46:247-254 1999
21. Zeng X, Goetz JA, Suber LM, et al: A freely diffusible form of Sonic hedgehog mediates long-range signalling. Nature 411:716-720, 2001
22. Warburton D, Schwartz M. Tefft D, et al: The molecular basis of lung morphogenesis. Mech Dev 92:55-81, 2000
23. Cunliffe VT. Ingham PW: Switching on the notochord. Genes Dev 13:1643-1646 1999
24. Takahashi H, Hotta K, Erives A, et al: Brachyury downstream notochord differentiation in the ascidian embryo. Genes Dev 13:1519-1523, 1999