DNA ploidy and Markovian analysis of neoplastic progression in experimental pancreatic cancer

Journal of Histochemistry and Cytochemistry

Volumn 51, Issue 3, 2003, Pages 303-309

  Postier, Russell G ^a   Lerner, Megan R ^a,b   Lightfoot, Stan A ^a,b   Vannarath, Rick ^a   Lane, Mary M ^a,b   Hanas, Jay S ^a   Brackett, Daniel J ^a,b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Adenocarcinoma; Atypia; DNA ploidy; Markovian analysis; Pancreatic cancer; Pancreatitis; Premalignant neoplastic lesion

Indexed keywords

BIS(2 OXOPROPYL)NITROSAMINE;

ANEUPLOIDY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER GROWTH; CARCINOGENESIS; CELL NUCLEUS; CELL POPULATION; CELL TYPE; CELL ULTRASTRUCTURE; COMPUTER ANALYSIS; CONTROLLED STUDY; DIPLOIDY; EXPERIMENTAL NEOPLASM; FEMALE; FEULGEN STAINING; FLOW CYTOMETRY; HISTOGRAM; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LOGISTIC REGRESSION ANALYSIS; MICROSCOPY; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREAS CELL; PANCREATITIS; PLOIDY; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SYRIAN HAMSTER; TISSUE SECTION;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS;

EID: 0037369817     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215540305100305     Document Type: Article

References (36)

1. Alborea-Saavedra J, Henson DE, Milchgrub S (1994) Intraductal papillary carcinoma of the main pancreatic duct. Int J Pancreatol 16:223-234
2. Bacus JW, Grace LJ (1987) Optical microscope system for standardized cell measurements and analyses. Appl Optics 26:3280-3293
3. Capella G, Farre L, Villanueva A, Reyes G, Garcia C, Tarafa G, Lluis F (1999) Orthotopic models of human pancreatic cancer. Ann NY Acad Sci 880:103-109
4. Casey G, Yamanaka Y, Friess H, Kobrin MS, Lopez ME, Buchler M, Beget HG, et al. (1993) p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis. Cancer Lett 69:152-160
5. Chang K-W, Laconi S, Mangold KA, Hubchak S, Scarpelli DG (1995) Multiple genetic alterations in hamster pancreatic ductal adenocarcinomas. Cancer Res 55:2560-2568
6. Dawson AE, Cibas ES, Bacus JW, Weinberg DS (1993) Chromatin texture measurement by Markovian analysis. Anal Quant Cytol Histol 15:227-235
7. Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61:759-767
8. Finkelstein SD, Przygodzki R, Pricolo VE, Sayegh R, Bakker A, Swalsky PA, Keller G (1994) K-ras-2 topographic genotyping of pancreatic adenocarcinoma. Arch Surg 129:367-373
9. Fishel R, Lescoe MK, Rao MRS, Copeland MG, Jenkins N, Garber J, Kane M, et al. (1993) The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75:1027-1038
10. Fujii H, Egami H, Chaney W, Pour P, Pelling J (1990) Pancreatic ductal adenocarcinomas induced in Syrian hamsters by N-nitrosobis (2-oxopropyl) amine contain a c-Ki-ras oncogene with a point-mutated codon. Mol Carcinogen 3:296-301
11. Goelz SE, Vogelstein B, Hamilton SR, Feinberg AP (1985) Hypomethylation of DNA from benign and malignant human colon neoplasms. Science 228:187-190
12. WAF1/CIP1 and p53 tumor suppressor dysplastic progression and adenocarcinoma in Barrett esophagus. Cancer 86:756-763
13. Kaino M (1997) Alterations in the tumor suppressor genes p53, RB, p16/MTS1, and p15/MTS2 in human pancreatic cancer and hepatoma cell lines. J Gastroenterol 32:40-46
14. Killough BW, Nichols C, Nicholson JA, Gansler TS (1989) Diagnosis of pancreatic carcinoma by fine needle aspiration cytology and computerized cytomorphometry. Anal Quant Cytol Histol 11: 238-242
15. Kondo H, Sugano K, Fukayama N, Kyogoku A, Nose H, Shimada K, Ohkura H, et al. (1994) Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma. Cancer 73:1589-1594
16. Linder S, Lindholm J, Falkmer U, Blasjo M, Sundelin P, von Rosen A (1995) Combined use of nuclear morphometry and DNA ploidy as prognostic indicators in nonresectable adenocarcinoma of the pancreas. Int J Pancreatol 18:241-248
17. Lipponen PK, Eskelinen MJ, Collan Y (1990) Nuclear morphometry in human pancreatic adenocarcinoma; relation to histologic grade, clinical stage, and survival. Ital J Gastroenterol 22:124-128
18. Majima T, Tsujiuchi T, Tsutsumi M, Tsunoda T, Konishi Y (1997) Mutations of K-ras but not p53 genes in biliary duct and pancreatic duct carcinomas induced in hamsters by cholecystoduodenostomy with dissection of the common duct followed by N-nitrosobis(2-oxopropyl) amine. Cancer Lett 118:47-53
19. Milchgrub S, Campuzano M, Casillas J, Albores-Saavedra J (1992) Intraductal carcinoma of the pancreas. Cancer 69:651-656
20. Muscarella P, Knobloch TJ, Ulrich AB, Casto BC, Moniaux N, Wittel UA, Melvin WS, et al. (2001) Identification and sequencing of the Syrian golden hamster (Mesocricetus auratus) p16(INK4a) and p15(INK4b) cDNAs and their homozygous gene deletion in cheek pouch and pancreatic tumor cells. Gene 278:235-243
21. Nakaizumi A, Tatsuta M, Uehara H, Takenaka A, Iishi H, Kitamra T, Ohigashi H, et al. (1995) Effectiveness of the cytologic examination of pure pancreatic juice in the diagnosis of early neoplasia of the pancreas. Cancer 76:750-757
22. Naumann M, Savitskaia N, Eilert C, Kalthoff H, Schmiegel W (1996) Frequent codeletion of P16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors. Gastroenterology 119:1215-1224
23. Papadopoulos N, Nicolaides NC, Wei YF, Ruben SM, Carter KC, Rosen CA, Haseltine WA (1994) Mutation of a mutL homolog in hereditary colon cancer. Science 263:1625-1628
24. Pour P, Althoff J, Kruger J, Mohr U (1977a) A potent pancreatic carcinogen in Syrian hamsters: N-nitrosobis (2-oxopropyl) amine. J Natl Cancer Inst 58:1449-1453
25. Pour P, Althoff J, Kruger J, Mohr U (1977b) Improvement of pancreatic cancer model by modified treatment with N-nitrosobis (2-oxopropyl) amine. Cancer Lett 2:233-237
26. Pressman NJ (1976) Markovian analysis of cervical images. J Histochem Cytochem 24:138-144
27. Schmied BM, Ulrich A, Matsuzaki H, Li CH, Pour PM (1999) In vitro pancreatic carcinogenesis. Ann Oncol Suppl 4:41-46
28. Shyr YM, Su CH, Li AF, Wu CW, Lui WY (1999) The role of MIB-1 index in the prognoses of resectable pancreatic head cancer. Hepatogastroenterol 46:2968-2973
29. Simon B, Weinel R, Hohne M, Watz J, Schmidt J, Kortner G, Arnold R (1994) Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma. Gastroenterology 106:1645-1651
30. Sugio K, Gazdar AF, Albores-Saavedra J, Kokkinakis DM (1996) High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso (2-hydroxypropyl) (2-oxopropyl) amine in the pancreas of female Syrian hamsters. Carcinogen 17:303-309
31. Tsutsumi M, Kondoh S, Noguchi O, Horiguchi K, Kobayashi E, Okita S, Ohashi K, et al. (1993) K-ras gene mutation in early ductal lesions induced in a rapid production model for pancreatic carcinomas in Syrian hamsters. Jpn J Cancer Res 84:1101-1105
32. Veltri RW, Partin AW, Epstein JE, Marley GM, Millar CM, Singer DS, Patton KP, et al. (1994) Quantitative nuclear morphometry, Markovian texture descriptors, and DNA content captured on a CAS-200 image analysis system, combined with PCNA and HER-2/neu immunohistochemistry for prediction of prostate cancer progression. J Cell Biochem Suppl 19:249-258
33. Watanabe H, Sawabu N, Ohta H, Satomura Y, Yamakawa O, Motoo Y, Okai T, et al. (1993) Identification of K-ras oncogene mutations in the pure pancreatic juice of patients with ductal pancreatic cancers. Jpn J Cancer Res 84:961-965
34. Yamashita K, Kida Y, Shinoda H, Kida M, Okayasu I (1999) K-ras point mutations in the supernatants of pancreatic juice and bile reliable for diagnosis of pancreas and biliary tract carcinomas complementary to cytologic examination. Jpn J Cancer Res 90: 240-248
35. Yanagisawa A, Otake K, Ohashi K, Hori M, Kitagawa T, Sugano H, Kato Y (1993) Frequent c-Ki-ras oncogene activation in mucous cell hyperplasia of pancreas suffering from chronic inflammation. Cancer Res 53:953-956
36. Yokomatsu H, Hiura A, Tsutsumi M, Satake K (1996) Inhibitory effect of sarcophytol A on pancreatic carcinogenesis after initiation by N-nitrosobis(2-oxypropyl) amine in Syrian hamsters. Pancreas 13:154-159