Plasminogen directs the pleiotropic effects of uPA in liver injury and repair

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 284, Issue 3 47-3, 2003, Pages

  Currier, Angela R ^a   Sabla, Gregg ^a   Locaputo, Stephanie ^a   Melin Aldana, Hector ^a   Degen, Jay L ^a   Bezerra, Jorge A ^a,b  

^a UNIVERSITY OF CINCINNATI   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Hepatocyte; Proliferation; Regeneration; Tissue remodeling; Urokinase

Indexed keywords

PLASMINOGEN; UROKINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; HISTOPATHOLOGY; LIVER CELL DAMAGE; LIVER INJURY; LIVER REGENERATION; MOLECULAR MECHANICS; MOUSE; NEWBORN MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; REGENERATIVE ABILITY;

EID: 0037369395     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00336.2002     Document Type: Article

References (28)

1. Andreasen PA, Egelund R, and Petersen HH. The plasminogen activation system in tumor growth, invasion, and metastasis. Cell Mol Life Sci 57: 25-40, 2000.
2. Andreasen PA, Kjoller L, Christensen L, and Duffy MJ. The urokinase-type plasminogen activator system in cancer metastasis: a review. Int J Cancer 72: 1-22, 1997.
3. Bezerra JA, Bugge TH, Melin-Aldana H, Sabla G, Kombrinck KW, Witte DP, and Degen JL. Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver. Proc Natl Acad Sci USA 96: 15143-15148, 1999.
4. Bezerra JA, Currier AR, Melin-Aldana H, Sabla G, Bugge TH, Kombrinck KW, and Degen JL. Plasminogen activators direct reorganization of the liver lobule after acute injury. Am J Pathol 158: 921-929, 2001.
5. Brodsky S, Chen J, Lee A, Akassoglou K, Norman J, and Goligorsky MS. Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesis. Am J Physiol Heart Circ Physiol 281: H1784-H1792, 2001.
6. Bugge TH, Flick MJ, Daugherty CC, and Degen JL. Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Genes Dev 9: 794-807, 1995.
7. Bugge TH, Kombrinck KW, Flick MJ, Daugherty CC, Danton MJ, and Degen JL. Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency. Cell 87: 709-719, 1996.
8. Bugge TH, Kombrinck KW, Xiao Q, Holmback K, Daugherty CC, Witte DP, and Degen JL. Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice. Blood 90:4522-4531, 1997.
9. Bugge TH, Lund LR, Kombrinck KK, Nielsen BS, Holmback K, Drew AF, Flick MJ, Witte DP, Dano K, and Degen JL. Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice. Oncogene 16: 3097-3104, 1998.
10. Degen SJ, Bell SM, Schaefer LA, and Elliott RW. Characterization of the cDNA coding for mouse plasminogen and localization of the gene to mouse chromosome 17. Genomics 8: 49-61, 1990.
11. Grisham J. A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver: autoradiography with thymidine-H3. Cancer Res 22: 842-849, 1962.
12. Heckel JL, Sandgren EP, Degen JL, Palmiter RD, and Brinster RL. Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator. Cell 62: 447-456, 1990.
13. Locaputo S, Carrick TL, and Bezerra JA. Zonal regulation of gene expression during liver regeneration of urokinase transgenic mice. Hepatology 29: 1106-1113, 1999.
14. Mars WM, Liu ML, Kitson RP, Goldfarb RH, Gabauer MK, and Michalopoulos GK. Immediate early detection of urokinase receptor after partial hepatectomy and its implications for initiation of liver regeneration. Hepatology 21: 1695-1701, 1995.
15. Mars WM, Zarnegar R, and Michalopoulos GK. Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA. Am J Pathol 143: 949-958, 1993.
16. Michalopoulos GK and DeFrances MC. Liver regeneration. Science 276: 60-66, 1997.
17. Ng VL, Sabla GE, Melin-Aldana H, Kelley-Loughnane N, Degen JL, and Bezerra JA. Plasminogen deficiency results in poor clearance of non-fibrin matrix and persistent activation of hepatic stellate cells after an acute injury. J Hepatol 35: 781-789, 2001.
18. Ploplis VA, Carmeliet P, Vazirzadeh S, Van Vlaenderen I, Moons L, Plow EF, and Collen D. Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice. Circulation 92: 2585-2593, 1995.
19. Pohl JF, Melin-Aldana H, Sabla G, Degen JL, and Bezerra JA. Plasminogen deficiency leads to impaired lobular reorganization and matrix accumulation after chronic liver injury. Am J Pathol 159: 2179-2186, 2001.
20. Recknagel RO, Glende EA Jr, Dolak JA, and Waller RL. Mechanisms of carbon tetrachloride toxicity. Pharmacol Ther 43: 139-154, 1989.
21. Romer J, Bugge TH, Pyke C, Lund LR, Flick MJ, Degen JL, and Dano K. Impaired wound healing in mice with a disrupted plasminogen gene. Nat Med 2: 287-292, 1996.
22. Romer J, Bugge TH, Pyke C, Lund LR, Flick MJ, Degen JL, and Dano K. Plasminogen and wound healing. Nat Med 2: 725, 1996.
23. Roselli HT, Su M, Washington K, Kerins DM, Vaughan DE, and Russell WE. Liver regeneration is transiently impaired in urokinase-deficient mice. Am J Physiol Gastrointest Liver Physiol 275: G1472-G1479, 1998.
24. Salgado S, Garcia J, Vera J, Siller F, Bueno M, Miranda A, Segura A, Grijalva G, Segura J, Orozco H, Hernandez-Pando R, Fafutis M, Aguilar LK, Aguilar-Cordova E, and Armendariz-Borunda J. Liver cirrhosis is reverted by urokinase-type plasminogen activator gene therapy. Mol Ther 2: 545-551, 2000.
25. Sandgren EP, Palmiter RD, Heckel JL, Daugherty CC, Brinster RL, and Degen JL. Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. Cell 66: 245-256, 1991.
26. Vassalli JD, Sappino AP, and Belin D. The plasminogen activator/plasmin system. J Clin Invest 88: 1067-1072, 1991.
27. Yazigi NA, Carrick TL, Bucuvalas JC, Schmidt CS, Balistreri WF, and Bezerra JA. Expansion of transplanted hepatocytes during liver regeneration. Transplantation 64: 816-820, 1997.
28. Zhang L, Seiffert D, Fowler BJ, Jenkins GR, Thinnes TC, Loskutoff DJ, Parmer RJ, and Miles LA. Plasminogen has a broad extrahepatic distribution. Thromb Haemost 87: 493-501, 2002.