Immune reactions in skin and hair follicle gene therapy

Molecular Therapy

Volumn 7, Issue 3, 2003, Pages 294-295

  Hoffman, Robert M ^a  

^a ANTICANCER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CD4 ANTIGEN; CD8 ANTIGEN; HEPATITIS B SURFACE ANTIGEN; IMMUNOSUPPRESSIVE AGENT; PLASMID VECTOR; RETROVIRUS VECTOR; SONIC HEDGEHOG PROTEIN;

FIBROBLAST; GENE EXPRESSION; GENE LOSS; HAIR FOLLICLE; HAIR GROWTH; HELPER CELL; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOSUPPRESSIVE TREATMENT; KERATINOCYTE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; NOTE; SIDE EFFECT; SKIN;

ERINACEIDAE; UNIDENTIFIED RETROVIRUS;

EID: 0037367542     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1525-0016(03)00040-6     Document Type: Note

References (10)

1. Ghazizadeh, S., Kalish, R. S., and Taichman, L. B. (2003). Immune-mediated loss of transgene expression in skin: implications for cutaneous gene therapy. Mol. Ther. 7: 296-303.
2. + T cells in major histocompatibility complex class II-deficient mice. Science 253: 1417-1420.
3. Paus, R., and Cotsarelis, G. (1999). The biology of hair follicles. N. Engl. J. Med. 341: 491-497.
4. Li, L, and Hoffman, R. M. (1995). The feasibility of targeted selective gene therapy of the hair follicle. Nat. Med. 1: 705-706.
5. Domashenko, A., Gupta, S., and Cotsarelis, G. (2000). Efficient delivery of transgenes to human hairfollicle progenitor cells using topical lipoplex. Nat. Biotechnol. 18: 420-423.
6. Christoph, T., et al. (2000). The human hair follicle immune system: cellular composition and immune privilege. Br. J. Derm. 142: 862-873.
7. Sato, N., Leopold, P. L., and Crystal, R. G. (1999). Induction of the hair growth phase in postnatal mice by localized transient expression of sonic hedgehog. J. Clin. Invest. 104: 855-864.
8. Saito, N., et al. (2002). High-efficiency genetic modification of hair follicles and growing hair shafts. Proc. Natl. Acad. Sci. USA 99: 13120-13124.
9. Reynolds, A. J., et al. (2000). Trans-gender induction of hair follicles. Nature 402: 33-34.
10. Fan, H., et al, (1999). Immunization via hair follicles by topical application of naked DNA to normal skin. Nat. Biotechnol. 17: 870-872.