Immunoreactivity of Hep Par 1 in hepatic and extrahepatic tumors and its correlation with albumin in situ hybridization in hepatocellular carcinoma

American Journal of Clinical Pathology

Volumn 119, Issue 3, 2003, Pages 361-366

  Kakar, Sanjay ^b   Muir, Trudie ^b   Murphy, Linda M ^b   Lloyd, Ricardo V ^b   Burgart, Lawrence J ^a  

^a MAYO CLINIC   (United States)

^b NONE

Author keywords

Adenocarcinoma; Albumin; Cholangiocarcinoma; Hep Par 1; Hepatocellular carcinoma; Immunohistochemistry; In situ hybridization

Indexed keywords

HEPATOCYTE PARAFFIN 1 MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY; TUMOR MARKER; UNCLASSIFIED DRUG; ALBUMINOID; MESSENGER RNA; TUMOR ANTIGEN;

ADRENAL CORTEX CARCINOMA; ARTICLE; BILE DUCT CARCINOMA; BLADDER CARCINOMA; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; ESOPHAGUS CARCINOMA; EVALUATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; KIDNEY CARCINOMA; LIVER CELL CARCINOMA; LIVER METASTASIS; LIVER TUMOR; LUNG ADENOCARCINOMA; MAJOR CLINICAL STUDY; PANCREAS ADENOCARCINOMA; PANCREAS ISLET CELL TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY; STOMACH ADENOCARCINOMA; TECHNIQUE; CANCER STAGING; GENETICS; IMMUNOLOGY; LIVER CELL; LUNG TUMOR; METABOLISM; METASTASIS; PATHOLOGY;

ALBUMINS; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; CARCINOMA, HEPATOCELLULAR; CHOLANGIOCARCINOMA; HEPATOCYTES; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIVER NEOPLASMS; LUNG NEOPLASMS; NEOPLASM STAGING; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 0037362801     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/8L872RPHEJRKF5JJ     Document Type: Article

References (13)

1. Minervini MI, Demetris AJ, Lee RG, et al. Utilization of hepatocyte-specific antibody in the immunocytochemical evaluation of liver tumors. Mod Pathol. 1997;10:686-692.
2. Ganjei P, Nadji M, Albores-Saavedra J, et al. Histologic markers in primary and metastatic tumors of the liver. Cancer. 1988;62:1994-1998.
3. Hurlimann J, Gardiol D. Immunohistochemistry in the differential diagnosis of liver carcinomas. Am J Surg Pathol. 1991;15:280-288.
4. Johnson DE, Powers CN, Rupp G, et al. Immunocytochemical staining of fine-needle aspiration biopsies of the liver as a diagnostic tool for hepatocellular carcinoma. Mod Pathol. 1992;5:117-123.
5. Ma CK, Zarbo RJ, Frierson HF Jr, et al. Comparative immunohistochemical study of primary and metastatic carcinomas of the liver. Am J Clin Pathol. 1999;99:551-557.
6. Yamaguchi K, Nalesnik MA, Carr BI. In situ hybridization of albumin mRNA in normal liver and liver tumors: identification of hepatocellular origin. Virchows Arch B Cell Pathol Incl Mol Pathol. 1993;64:361-365.
7. Krishna M, Lloyd RV, Batts KP. Detection of albumin messenger RNA in hepatic and extrahepatic neoplasms: a marker of hepatocellular differentiation. Am J Surg Pathol. 1997;21:147-152.
8. Oliveira AM, Erickson LA, Burgart LJ, et al. Differentiation of primary and metastatic clear cell tumors in the liver by in situ hybridization for albumin messenger RNA. Am J Surg Pathol. 2000;24:177-182.
9. Wennerberg AE, Nalesnik MA, Coleman WB. Hepatocyte paraffin I: a monoclonal antibody that reacts with hepatocytes and can be used for differential diagnosis of hepatic tumors. Am J Pathol. 1993;143:1050-1054.
10. Leong AS, Sormunen RT, Tsui WM, et al. Hep Par 1 and selected antibodies in the immunohistological distinction of hepatocellular carcinoma from cholangiocarcinoma, combined tumours and metastatic carcinoma. Histopathology. 1998;33:318-324.
11. Zimmerman RL, Burke MA, Young NA, et al. Diagnostic value of hepatocyte paraffin 1 antibody to discriminate hepatocellular carcinoma from metastatic carcinoma in fine-needle aspiration biopsies of the liver. Cancer. 2001;93:288-291.
12. Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer. 1954;7:462-503.
13. Maitra A, Murakata LA, Albores-Saavedra J. Immunoreactivity for hepatocyte paraffin 1 antibody in hepatoid adenocarcinomas of the gastrointestinal tract. Am J Clin Pathol. 2001;115:689-694.