Effect of Nigella sativa on blood hemostatic function in rats

Journal of Ethnopharmacology

Volumn 85, Issue 1, 2003, Pages 7-14

  Al Jishi, S A ^a,b   Abuo Hozaifa, B ^a  

^a IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY   (Saudi Arabia)

^b NONE   (Saudi Arabia)

Author keywords

Blood coagulation; Liver function tests; Nigella sativa

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ANTITHROMBIN III; ASPARTATE AMINOTRANSFERASE; FIBRINOGEN; NIGELLA SATIVA EXTRACT;

ANIMAL EXPERIMENT; ARTICLE; BLOOD; BLOOD CLOTTING; CONTROLLED STUDY; DOSE RESPONSE; FEEDING BEHAVIOR; HEMOSTASIS; LIVER FUNCTION TEST; MALE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PLANT SEED; PROTHROMBIN TIME; RAT; THROMBIN TIME; THROMBOCYTE COUNT;

NIGELLA SATIVA;

EID: 0037361397     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(02)00356-2     Document Type: Article

References (42)

1. Al-Bukhari, M., 1983. Sahih Abi Abdullah Al-Bukhari. Maktabat Al-Nahdha Al-Haditha, Macca Al-Mukarrama, p. 107.
2. Al-Gaby A.M. Amino acid composition and biological effects of supplementing broad bean and corn proteins with Nigella sativa (black cumin) cake protein. Die Nahrung. 42:1998;290-294.
3. Al-Hwsawii, Z., 2000. Effect of Nigella sativa on blood glucose, lipids, and uric acid in rats. M.Sc. thesis in King Faisal University in Dammam, Saudi Arabia.
4. Altes A., Abellan M.T., Mateo J., Avila A., Marti-Vilalta J.L., Fontcuberta J. Hemostatic disturbances in acute ischemic stroke: a study of 86 patients. Acta Haematologica. 94:1995;10-15.
5. Balisteri, W.F., 1996. Liver function. In: Burtis, C.A., Ashwood, A.R. (Eds.), Tietz Fundamentals of Clinical Chemistry. WB Saunders, Philadelphia, PA.
6. Bell W.N., Alton H.G. A brain extract as a substitute for platelet suspensions in the thromboplastin generation test. Nature. 174:1954;880-881.
7. Black, D.D., 1996. Gastrointestinal, Hepatobiliary, and Nutritional Physiology. Lippincott-Raven, Philadelphia, PA, pp. 223-227.
8. Carvalho de Sousa J., Bruckert E., Giral P., Soria C., Truffert J., Mishahi M., de Gennes J.L., Caen J.P. Plasma factor VII, triglyceride concentration and fibrin degradation products in primary hyperlipidemia: a clinical and laboratory study. Haemostasis. 19:1989;83-90.
9. Clauss A. Gernnungsphysiologische Schnell methods zur Bestimmung des Fibringens. Acta Haematologica. 17:1957;237-246.
10. Daba M.H., Abdel-Rahman M.S. Hepatoprotective activity of thymoquinone in isolated rat hepatocyte. Toxicology Letters. 95:1998;23-29.
11. deGruchy, G.C., 1983. Clinical Haematology in Medical Practice. Blackwell Scientific Publications, UK, p. 698.
12. de Sain-van der velden M.G., Kaysen G.A., de Meer K., Stellaard F., Voorbij H.A., Reijngoud D.J., Rabelink T.J., Koomans H.A. Propotionate increase of fibrinogen and albumin synthesis in nephrotic patients: measurement with stable isotopes. Kidney International. 53:1998;181-188.
13. Doumas, B.T., 1982. Total protein and albumin in serum, urine, and cerebrospinal fluid. In: Faulkner, W.R., Meites, S. (Eds.), Selected Method of Clinical Chemistry. Association for Clinical Chemistry, Washington, DC.
14. Drozd A.G., Komissarenko F.N., Litvinenko L.V. Coumarines of some species of Ranunucleae family. Farmacie Zhurnal. 25:1970;57-60.
15. El-Dakhakhny, M., 1982. Some pharmacological properties of some constituents of Nigella sativa L. seeds: the carbonyl fraction of the essential oil. In: Proceedings of the Second International Conference on Islamic Medicine, Studies in Islamic Medicine and Advantages of Herbal Treatment in Kuwait. pp. 426-431.
16. El-Daly E.S. Protective effect of cysteine and Vitamin E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats. Journal de Pharmacie de Belgique. 53:1998;87-95.
17. El-Kadi, A., Kandil, O., 1987. The black seed (Nigella sativa) as a natural immune enhancer. In: Proceedings of the First International Conference on Scientific Miracles of Quran and Sunnah, Islamabad, Pakistan. p. 1.
18. El-Kadi A., Kandil O., Tabuni A. Nigella sativa and cell-mediated immunity. Archives of AIDS Research. 1:1987;232.
19. Elkeles R.S., Chakrabarti R., Viches M., Stirling Y., Mead T.W. Effects of treatment of hyperlipidemia on hemostatic variables. British Medical Journal. 281:1980;973-974.
20. El-Naggar A.R.M., El-Deib A.R.M. A study of some biological activities of Nigella sativa (black seeds) "Habat El-Baraka" Journal of Egyptian Society for Pharmacology and Experimental Therapeutics. 11:1992;781-800.
21. El-Shabrawy O.A., Nada S.A. Biological evaluation of multicomponent tea used as hypoglycemic in rats. Fitoterapia. LXVII:1996;99-102.
22. Empfehlugen der Deutschen Gesellschaft Fur Klinische Chemie, 1970. Stadardisierung von methoden von Enzymaktivitaten in biologischen Flussigkeiten. Zeitschrift Fur Klinische Chemie und Klinische Biochemie 8, 658.
23. Empfehlugen der Deutschen Gesellschatt Fur Klinische Chemie, 1972. Stadardisierung von methoden von Enzymaktivitaten in biologischen Flussigkeiten. Zeitschrift Fur Klinische Chemie und Klinische Biochemie 10, 182.
24. Eskander E.F., Jun H.W., Ibrahim K.A., Abdelal W.E. Hypoglycemic effect of a herbal formulation in alloxan induced diabetic rats. Egyptian Journal of Pharmacological Sciences. 36:1995;253-270.
25. Fareed J., Messmore H.L., Waegna J.M., Bermes E.W., Bick R.L. Laboratory evaluation of Antithrombin III: a critical overview of currently available methods for antithrombin III measurement. Seminars in Thrombosis and Haemostasis. 8:1982;288-301.
26. Furie B., Furie B.C. Molecular and cellular biology of blood coagulation. New England Journal of Medicine. 326:1992;800-806.
27. Ghoneim, M.T., El-Gindy, A.R., El-Alami, R., Shoukry, E., Yaseen, S., 1982. Possible effect of some extracts of Nigella sativa L. seeds on blood coagulation system and fibrinolytic activity. In: Proceedings of the Second International Conference on Islamic Medicine in Kuwait. pp. 528-535.
28. Hougie, C., 1990. Haematology. McGraw-Hill, USA, pp. 1770-1771.
29. Ibn Sina (Avecenna), 1037. Al-Qanoon Fit-Tib (Principles in Medicine). Reprinted in 1970 from Bulaq edition, Sader Publishing House, Beirut, Lebanon.
30. Mahfouz M., El-Dakhakhny M., Gemei A., Moussa H. Choleretic action of Nigella sativa L. seeds oil. Egyptian Pharmacology Bulletin. 44:1962;225.
31. Miller G.J., Walter S.J., Stirling Y., Thompson S.G., Esnouf M.P., Meade T.W. Assay of factor VII activity by two techniques: evidence for increased conversion of VII to VIIa in hyperlipidemia possible implications for ischemic heart disease. British Journal of Haematology. 59:1985;249-258.
32. Nagi M.N., Alam K., Badary O.A., Al-Shabanah O.A., Al-Sawaf H.A., Al-Bekairi A.M. Thymoquinone protects against carbon tetrachloride hepatotoxicity in mice via an antioxidant mechanism. Biochemistry and Molecular Biology International. 47:1999;153-159.
33. Nies, A.S., 1992. The Pharmacological Basis of Therapeutics. McGraw-Hill, New York, pp. P62-P83.
34. Patrassi G.M., Toffanin F., Massa G., Scivazappa L., Girolami A. Short heparin thrombin clotting time, increased fibrinogen and platelet aggregates count in coronary disease: a probable hypercoagulable state. Folia Haematologica: International Magazine Fur Klinische Und Morphologische Blutforschung. 106:1979;414-425.
35. Penner J.A. Experience with a thrombotic clotting time assay for measuring heparin activity. American Journal of Clinical Pathology. 61:1974;645-653.
36. Podolsky, D.K., 1991. Derangement of hepatic metabolism. In: Wilson, J.D., Braunwald, E., Isselbacher, K.J., Petersdorf, R.G., Martin, J.B., Fauci, A.S., Root, R.K. (Eds.), Principles of Internal Medicine, vol. 2. McGraw-Hill, New York.
37. Quick A.K., Stanley-Browm M., Bancroft F.W. A study of the coagulation defect in hemophilia and jaundice. American Journal of Medical Sciences. 190:1935;501-511.
38. Saad, S.I., 1975. Classification of the Flowering Plants. The General Egyptian Book Company, Alexandria, pp. 412-413.
39. Saber M.A., Abdel Salam I.M., Hammad H., ElKabbany M. Biochemical and pathological improvement in Schistosoma mansoni infected mice treated with Nigella sativa. Egyptian Journal of Biochemistry. 14:1996;119-127.
40. Simpson H.C.R., Meade T.W., Stirling Y., Mann J.I., Chakrabarti R., Woolf L. Hypertriglyceridemia and hypercoagulability. Lancet. 1:1983;786-790.
41. Tennekoon K.H., Jeevathayaparan S., Kurukulasooriya A.P., Karunanayake E.H. Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves. Journal of Ethnopharmacology. 31:1991;283-289.
42. Wright D., Poller L., Thomson J.M., Gowland E., Burrows G.E. The interrelationship of factor VII and its activity state with plasma lipids in healthy male adults. British Journal of Haematology. 85:1993;348-351.