Synthesis of [3-[2-(dimethylamino)ethyl]-2-[[3-(dimethylamino)ethyl]-1H-indol-5-yl] methyl]-1H-indol-5-yl]-N-methylmethanesulfonamide - The main sumatriptane impurity

Polish Journal of Chemistry

Volumn 77, Issue 3, 2003, Pages 329-332

  Skwierawska, A ^a   Paluszkiewicz, E ^a  

^a GDANSK UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Drug impurities; Indole derivatives; Sumatriptane

Indexed keywords

3 [2 (DIMETHYLAMINO)ETHYL] 5 INDOLEMETHANOL; [3 [2 (DIMETHYLAMINO)ETHYL] 2 [[3 (DIMETHYLAMINO)ETHYL] 1H INDOL 5 YL]METHYL] 1H INDOL 5 YL N METHYLMETHANESULFONAMIDE; INDOLE DERIVATIVE; METHANOL DERIVATIVE; SUMATRIPTAN; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHEMICAL REACTION; DRUG IMPURITY; SYNTHESIS;

EID: 0037360925     PISSN: 01375083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Hopkins S.J., Drugs Today, 28, 155 (1992).
2. Brodfuehrer P.R., Chen B.C., Sattelberg T.R., Smith Sr.P.R., Reddy J.P., Stark D.R., Quinlan S.L., Reid J.G., Thottathil J.K. and Wang S.J., J. Org. Chem., 62, 9192 (1997).
3. Fernandez M.D., Puig C., Crespo M.I. and Moragues J., ES Patent 2, 084, 560, (1994); C.A., 125, 221573 (1996).
4. European Pharmacopoeia 2001, 1573.
5. Bosch J., Roca T., Armengol M. and Fernandez-Forner D., Tetrahedron, 57, 1041 (2001).
6. Strret L.J., Baker R., Castro J.L., Chambers M.S., Guiblin A.R., Hobbs S.C., Matassa V.G., Reeve A.J., Beer M.S., Middlemiss D.N., Noble A.J., Stanton J.A., Scholey K. and Hargreaves R., J. Med. Chem., 36, 1529 (1993).
7. Mancuso A.J., Huang S.L. and Swern D., J. Org. Chem., 43, 12 (1978).
8. Hughes D.L. and Zhao D., J. Org. Chem., 58, 228 (1993).