Effects of combined octreotide and aspirin on the growth of gastric cancer

Chinese Medical Journal

Volumn 116, Issue 3, 2003, Pages 373-377

  Tang, Chengwei ^a   Wang, Chunhui ^a   Tang, Liping ^b  

^a SICHUAN UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Aspirin; Cyclooxygenase 2; Gastric cancer; Octreotide; Somatostatin

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOOXYGENASE 2; MESSENGER RNA; NONSTEROID ANTIINFLAMMATORY AGENT; OCTREOTIDE; PROSTAGLANDIN SYNTHASE INHIBITOR; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR; THYMIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; DRUG SAFETY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH ADENOCARCINOMA; STOMACH CANCER; STOMACH CARCINOMA; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ASPIRIN; HUMANS; MALE; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; OCTREOTIDE; RECEPTORS, SOMATOSTATIN; RNA, MESSENGER; STOMACH NEOPLASMS; TRANSPLANTATION, HETEROLOGOUS;

EID: 0037360317     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Luk GD. Tumors of the stomach. In: Feldman M, Scharschmidt BF, Sleisenger MH, eds. Sleisenger and Fordtran's gastrointestinal and liver disease. Beijing: Science Press; 1999:733-757.
2. Pollak MN, Schally AV. Mechanisms of antineoplastic action of somatostatin analogs. Pro Soc Exp Biol Med 1998;217:143-152.
3. Ohno R, Yoshinaga K, Fujita T, et al. Depth of invasion parallels increased cyclooxygenase-2 levels in patients with gastric carcinoma. Cancer 2001;91:1876-1881.
4. Tahara E. Molecular biology of gastric cancer. World J Surg 1995;19:484-490.
5. Douziech N, Calvo E, Coulombe Z, et al. Inhibitory and stimulatory effects of somatostatin on two human pancreatic cancer cell lines: a primary role for tyrosine phosphatase SHIP-1. Endocrinology 1999;140:765-777.
6. Ohnami S, Matsumoto N, Nakano M, et al. Identification of genes showing differential expression in antisense K-ras-transduced pancreatic cancer cells with suppressed tumorigenicity. Cancer Res 1999;59:5565-5571.
7. Feldman M. Gastric secretion: normal and abnormal. In: Feldman M, Scharschmidt BF, Sleisenger MH, eds. Sleisenger and Fordtran's gastrointestinal and liver disease. Beijing: Science Press; 1999:587-603.
8. Gibril F, Reynolds JC, Lubensky IA, et al. Ability of somatostatin receptor scintigraphy to identify patients with gastric carcinoids: a prospective study. J Nucl Med 2000;41:1646-1656.
9. Caplin ME, Buscombe JR, Hilson AJ, et al. Carcinoid tumor. Lancet 1998;352:799-805.
10. Wang C, Tang C. Inhibition of activator protein-1 on the growth of gastric cancer by octreotide. Chin J Cancer 2002;21:850-854.
11. Ding M, Dong Z, Chen F, et al. Asbestos induces activator protein-1 transactivation in transgenic mice. Cancer Res 1999; 59:1884-1889.
12. Todisco A, Campbell V, Dickinson CJ, et al. Molecular basis for somatostatin action: inhibition of c-fos expression and AP-1 binding. Am J Physicol 1994;267:G245-G253.
13. Pinski J, Halmos G, Yano T, et al. Inhibition of growth of MKN45 human gastric-carcinoma xenografts in nude mice by treatment with bombesin/gastrin-releasing-peptide antagonist (RC-3095) and somatostatin analogue RC-160. Int J Cancer 1994;57:574-580.
14. Wong BC, Zhu GH, Lam SK. Aspirin induced apoptosis in gastric cancer cells. Biomed Pharmacother 1999;53:315-318.
15. Smith WL, Garavito RM, DeWitt DL. Prostaglandin endoperoxide H synthases (cyclooxygenages)-1 and -2. J Biol Chem 1996; 271:33:1157-1160.
16. Song SH, Jong HS, Choi HH, et al. Transcriptional silencing of cyclooxygenase-2 by hyper-methylation of the 5′ CpG island in human gastric carcinoma cells. Cancer Res 2001;61:4628-4635.
17. Murata H, Kawano S, Tsuji S, et al. Cyclooxygenase-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma. Am J Gastroenterol 1999;94:451-455.
18. Todisco A, Seva C, Takeuchi Y, et al. Somatostatin inhibits AP-1 function via multiple protein phosphatases. Am J Physicol 1995;269:G160-G166.
19. Avgerinos A, Armonis A, Raptis S, et al. Somatostatin and octreotide in the management of acute variceal hemorrhage. Hepato Gastroenterol 1995;42:145-150.