Identification of a new mechanism for bacterial uptake at mucosal surfaces, which is mediated by dendritic cells

Pathologie Biologie

Volumn 51, Issue 2, 2003, Pages 69-70

  Rescigno, M ^a,b  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b NONE   (Italy)

Author keywords

Bacteria; Dendritic cells; Mucosal immunity; Tight junctions; Viruses

Indexed keywords

BACTERIAL INFECTION; CELL FUNCTION; CONFERENCE PAPER; DENDRITE; DENDRITIC CELL; EPITHELIUM CELL; IMMUNE RESPONSE; MUCOSA; MUCOSAL IMMUNITY; NONHUMAN; T LYMPHOCYTE ACTIVATION; VIRUS;

ANIMALS; BACTERIA; CELL SURFACE EXTENSIONS; DENDRITIC CELLS; GASTROINTESTINAL CONTENTS; HUMANS; INTERCELLULAR JUNCTIONS; PEYER'S PATCHES; PHAGOCYTOSIS;

EID: 0037358960     PISSN: 03698114     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0369-8114(03)00100-7     Document Type: Conference Paper

References (15)

1. Rescigno M, Borrow P. The host-pathogen interaction. New themes from dendritic cell biology. Cell 2001;106:267-70.
2. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245-52.
3. De Smedt T, Pajak B, Muraille E, Lespagnard L, Heinen E, De BP, et al. Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J Exp Med 1996;184:1413-24.
4. Robert C, Fuhlbrigge RC, Kieffer JD, Ayehunie S, Hynes RO, Cheng G, et al. Interaction of Dendritic Cells with Skin Endothelium: A New Perspective on Immunosurveillance. J Exp Med 1999;189:627-36.
5. Saeki H, Moore AM, Brown MJ, Hwang ST. Cutting edge: secondary lymphoid-tissue chemokine (SLC) and mL chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J Immunol 1999;162:2472-5.
6. Rescigno M, Granucci F, Citterio S, Foti M, Ricciardi-Casiagnoli P. Coordinated events during bacteria-induced DC maturation. Immunol Today 1999;20:200-3.
7. Rescigno M, Citterio S, Théry C, Rittig M, Medaglini D, Pozzi G, et al. Bacteria-induced neo-biosynthesis, stabilization and surface expression of functional class I molecules in mouse dendritic cells. Proc Natl Acad Sci USA 1998;95:5229-34.
8. Granucci F, Vizzardelli C, Pavelka N, Feau S, Persico M, Virzi E, et al. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat Immunol 2001;2:882-8.
9. Ruedl C, Hubele S. Maturation of Peyer's patch dendritic cells in vitro upon stimulation via cytokines or CD40 triggering. Eur J Immunol 1997;27:1325-30.
10. Iwasaki A, Kelsall BL. Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3alpha, MIP-3beta and secondary lymphoid organ chemokine. J Exp Med 2000;191:1381-94.
11. Kelsall BL, Strober W. Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch. J Exp Med 1996;183:237-47.
12. Rao AS, Roake JA, Larsen CP, Hankins DF, Morris PJ, et al. Isolation of dendritic leukocytes from non-lymphoid organs. Adv Exp Med Biol 1993;329:507-12.
13. Neutra MR. M cells in antigen sampling in mucosal tissues. Curr Top Microbiol Immunol 1999;236:17-32.
14. Rescigno M, Urbano M, Valzasina B, Francolini M, Rotta G, Bonasio R, et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2001;2:361-7.
15. Gewirtz AT, Simon PO, Schmitt CK, Taylor LJ, Hagedorn CH, O'Brien A. D. and al., Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response. J Clin Invest 2001;107:99-109.