Dual effect of agmatine in the bisected rat vas deferens

Journal of Pharmacy and Pharmacology

Volumn 55, Issue 3, 2003, Pages 373-380

  Santos, Wilson C ^a   Smaili, Soraya S ^b   Jurkiewicz, Aron ^b   Piçarro, Ivan ^b   Garcez Do Carmo, Lúcia ^b  

^a FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; ADENOSINE TRIPHOSPHATE; AGMATINE; ALPHA 2 ADRENERGIC RECEPTOR; CLONIDINE; CROMAKALIM; IDAZOXAN; IMIDAZOLINE RECEPTOR; MOXONIDINE; NORADRENALIN; PHENOXYBENZAMINE; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; PRAZOSIN; SURAMIN; TETRODOTOXIN; TETRYLAMMONIUM CHLORIDE; YOHIMBINE;

ADRENERGIC TRANSMISSION; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; DRUG POTENTIATION; ELECTROSTIMULATION; EPIDIDYMIS; IC 50; MALE; MUSCLE TWITCH; NONHUMAN; POSTSYNAPTIC INHIBITION; PRESYNAPTIC INHIBITION; PROSTATE; RAT; SMOOTH MUSCLE CONTRACTION; VAS DEFERENS;

ADENOSINE TRIPHOSPHATE; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; AGMATINE; ANIMALS; CLONIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; EPIDIDYMIS; IDAZOXAN; IMIDAZOLES; MALE; MUSCLE CONTRACTION; NOREPINEPHRINE; PHENOXYBENZAMINE; POTASSIUM CHLORIDE; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, DRUG; SYMPATHETIC NERVOUS SYSTEM; SYNAPTIC TRANSMISSION; VAS DEFERENS; YOHIMBINE;

EID: 0037355848     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/002235702720     Document Type: Article

References (41)

1. Anton, P. A., Duncan, M. E., McGrath, J. C. (1977) An analysis of the anatomical basis for the mechanical response to motor nerve stimulation of the rat vas deferens. J. Physiol. 273: 23-43
2. Arunlakshana, O., Schild, H. O. (1959) Some quantitative use of drug antagonists. Br. J. Pharmacol. 14: 48-58
3. Avellar, M. C. W., Markus, R. (1996) Are there imidazoline receptors in sympathetic neurotransmission in rat vas deferens? Gen. Pharmacol. 27: 1273-1278
4. Browne, I., Thomas, G., Gavin, K., Docherty, J. R. (1994) Prejunctional actions of N-ethyl-maleimide and phenoxybenzamine in rat vas deferens. Eur. J. Pharmacol. 265: 125-132
5. 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated vas deferens. Br. J. Pharmacol. 117: 224-230
6. 2+ influx stimulated by diacylglycerol and PKC. Br. J. Pharmacol. 123: 317-325
7. ATP channels. Clin. Exp. Pharmacol. Physiol. 21: 583-597
8. Demady, D. R., Jianmongkol, S., Vuletich, J. L., Bender, A. T., Osawa, Y. (2001) Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme. Mol. Pharmacol. 59: 24-29
9. + channels blockers in rat vas deferens. Eur. J. Pharmacol. 287: 287-293
10. Doxey, J. C., Roach, A. G. (1980) Presynaptic alpha-adrenoceptors: In vitro methods and preparations utilised in the evaluation of agonists and antagonists. J. Auton. Pharmacol. 1: 73-99
11. Edwards, G., Weston, A. H. (1990) Potassium channel openers and vascular smooth muscle relaxation. Pharmacol. Ther. 48: 237-258
12. Eglen, R. M., Hudson, A. L., Kendall, D. A., Nutt, D. J., Morgan, N. G., Wilson, V. G., Dillon, M. P. (1998) Seeing through a glass darkly: Casting light on imidazoline "I" sites. Trends Pharmacol. Sci. 19: 381-390
13. 1-Imidazoline receptors: Definition, characterisation, distribution, and transmembrane signalling. Ann. NY Acad. Sci. 763: 22-42
14. Furchgott, R. F. (1966) The use of β-haloalkylamines in the differentiation of receptors and in the determination of dissociation constants of receptor-agonist complexes. In: Harper, N. J., Simmonds, A. B. (eds) Advances in Drug Research., Vol. 3, Academic Press, London, pp 21-55
15. Furchgott, R. F. (1972) The classification of adrenoceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory. In: Blashko, H., Muscholl, E. (eds) Handbook of Experimental Pharmacology, Catecholamines. Vol. 33, Springer-Verlag, Berlin, p 283-335
16. García, A. G., Sala, F., Reig, J. A., Viniegra, S., Frías, J., Fontériz, R., Gandía, L. (1984) Dihydropyridine BAY-K-8644 activates chromaffin cell calcium channels. Nature 308: 69-71
17. González, C., Regunathan, S., Reis, D. J., Estrada, C. (1996) Agmatine, an endogenous modulator of noradrenergic neurotransmission in the rat tail artery. Br. J. Pharmacol. 119: 677-684
18. Hamilton, T. C., Weston, A. H. (1989) Cromakalim, nicorandil and pinacidil: Novel drugs which open potassium channels in smooth muscle. Gen. Pharmacol. 20: 1-9
19. Jurkiewicz, N. H., Garcez-do-Carmo, L., Hirata, H., Santos, W. C., Jurkiewicz, A. (1996) Functional properties of agmatine in rat vas deferens. Eur. J. Pharmacol. 307: 299-304
20. 3[H]idazoxan binding at non alpha 2-adrenoceptors in rabbit adipocytes membranes. Eur. J. Pharmacol. 159: 199-203
21. Li, G., Regunathan, S., Barrow, C. J., Eshraghi, J., Cooper, R., Reis, D. J. (1994) Agmatine: An endogenous clonidine-displacing substance in the brain. Science 263: 966-969
22. Loring, R. H. (1990) Agmatine acts as an antagonist of neuronal nicotine receptors. Br. J. Pharmacol. 99: 207-211
23. Molderings, G. J., Gothert, M. (1998) Imidazoline binding sites and receptors in cardiovascular tissue. Gen. Pharmacol. 32: 17-22
24. 2D-adrenoceptors: Competitive antagonism and allosteric activation. Br. J. Pharmacol. 130: 1706-1712
25. Morrisseyu, J. J., Klahr, S. (1997) Agmatine activation of nitric oxide synthase in endothelial cells. Proc. Assoc. Am. Phys. 109: 51-57
26. Nakazawa, K., Matsuki. N., Shigenobu, K., Kasuya, Y. (1987) Contractile response and electrophysiological properties in enzymatically dispersed smooth muscle cells of rat vas deferens. Pflugers Arch. 408: 112-119
27. Picarelli, Z. P., Hypollito, N., Valle, J. R. (1962) Synergyst effect of 5-hydroxytriptamine on the response of rat seminal vesicle to adrenaline and noradrenaline. Arch. Int. Pharmacodyn. 138: 354-363
28. Piletz, J. E., Chikkala, D. N., Ernsberger, P. (1995) Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazolines and alpha-2 receptors. J. Pharmacol. Exp. Ther. 272: 581-587
29. 2-adrenoceptors. Naunyn Schmiedebergs Arch. Pharmacol. 351: 10-16
30. Raasch, W., Schäfer, U., Chun, J., Dominiak, P. (2001) Biological significance of agmatine, an endogenous ligand at imidazoline binding sites. Br. J. Pharmacol. 133: 755-780
31. Reis, D. J., Regunathan, S. (2000) Is agmatine a novel neuro-transmitter in brain? Trends. Pharmacol. Sci. 21: 187-193
32. Rohde, G. C., Veneziane, E., Huidobro-Toro, J. P. (1986) Asymmetric distribution of purinergic and adrenergic neuro-transmission co-operates in the motor activity along the rat vas deferens. Neurosci. Lett. 71: 197-202
33. Santos, W. C., Hernández-Guijo, J. M. Ruiz-Nuño, A., Olivares, R., Jurkiewicz, A., Gandía, L., Garcípa, A. G. (2001) Blockade by agmatine of catecholamine release from chromaffin cells is unrelated to imidazoline receptors. Eur. J. Pharmacol. 417: 99-109
34. 2-autoreceptors are involved in the blood pressure-lowering effect of moxonidine. J. Cardiovasc. Pharmacol. 16: 15-22
35. Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, P. E., Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. Br. J. Pharmacol. 119: 911-916
36. Sneddon, P., Westfall, D. P., Colby, J., Fedan, J. S. (1984) A pharmacological investigation of the biphasic nature of the contractile response of rabbit and rat vas deferens to field stimulation. Life Sci. 35: 1903-1912
37. Starke, K., Gothert, M., Kilbinger, H. (1989) Modulation of neurotransmitter release by presynaptic autoreceptors. Physiol. Rev. 69: 864-989
38. Van Rossum, J. M. (1963) Cumulative dose-response curves ii. Technique for the making of dose-response curves in isolated organs and evaluations of drug parameters. Arch. Int. Pharmacodyn. 143: 299-330
39. Ventura, S. (1998) Autoinhibition, sympathetic cotransmission and biphasic contractile responses to trains of nerve stimulation in the rodent vas deferens. Clin. Exp. Pharmacol. Physiol. 25: 965-973
40. 2-Adrenoceptors binding sites vary along the length of male reproductive tract: A possible basis for the regional variation in response to field stimulation. Eur. J. Pharmacol. 254: 167-173
41. Weitzell, R., Tanaka, T., Starke, K. (1979) Pre- and postsynaptic effects of yohimbine stereoisomers on noradrenergic transmission in the pulmonary artery of the rabbit. Naunyn Schmiedebergs Arch. Pharmacol. 308: 127-136