Liquid filling in hard gelatin capsules: Formulation and processing consideration

American Pharmaceutical Review

Volumn 6, Issue 1, 2003, Pages 14-21

  Shah, Navnit ^a   Phuapradit, Wantanee ^a   Ahmed, Hashim ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CAPTOPRIL; CEPHALOSPORIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DRUG VEHICLE; FATTY ACID; GELATIN; GLYCOL; LABRASOL; MACROGOL 400; OCTANOIN; POLOXAMER; PROPOLIS; VEGETABLE OIL;

ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; HUMAN; LIQUID; NONHUMAN; PARTICLE SIZE;

EID: 0037354270     PISSN: 10998012     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. N.H. Shah, W. Phuapradit, H. Ahmed, Liquid/semi-solid filling in hard gelatin capsules: formulation and processing considerations, semi-solid formulations and oral absorption enhancement, Bull Tech Gattefosse 89 (1996) 27-37.
2. W. Phuapradit, N.H. Shah, Y. Lou, S. Kundu, M.H. Infeld, Critical processing factors affecting rheological behavior of a wax based formulation, Eur. J. of Pharm. and Biopharm., 53 (2002) 175-179.
3. P. Timmins, I. Browning, N.I. Payne, Differential scanning calorime-trycharacterization of process-induced variations in an ointment base, J.Pharm. Pharmacol. 42 (1990) 583-585.
4. H. Loth, P. Bosche, Solidification of molten hard fats in dependence on the chemical composition and thermal pretreatment, Pharm. Ind. 58 (1996)161-166.
5. Seta, F. Higuchi, T. Otsuka, Y. Kawahara, K. Nishimura, R. Okada and H. Koike, "Preparation and pharmacological evaluation of Captopril sustained-release dosage forms using oily semisolid matrix", Int. J. Pharm., Vol. 41: 263-269 (1988).