Serum concentrations of dehydroepiandrosterone sulfate and leptin in obese patients with normal serum cholesterol

Metabolism: Clinical and Experimental

Volumn 52, Issue 3, 2003, Pages 379-381

  Vierhapper, H ^a   Heinze, G ^a   Nowotny, P ^a   Bieglmayer, C ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; LIPID; PRASTERONE SULFATE;

ADULT; AGE; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MARKER; FEMALE; GENDER; HORMONE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL;

EID: 0037354212     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1053/meta.2003.50059     Document Type: Article

References (32)

1. Miller DC, Trulson MF, McCann MB, et al: Diet, blood lipids and health of Italian men in Boston. Ann Intern Med 49:1178-1200, 1958
2. Vierhapper H, Nardi A, Grösser P: Prevalence of paradoxically normal serum concentrations of cholesterol in morbidly obese women. Metabolism 49:607-610, 2000
3. Rosenbaum M, Leibel RL, Hirsch J: Obesity. N Engl J Med 337:396-407, 1997
4. Zumoff B, Bradlow HL: Sex difference in the metabolism of dehydroisoandrosterone sulfate. J Clin Endocrinol Metab 51:334-336, 1980
5. Longcope C: The metabolism of DHEA. Ann NY Acad Sci 774:143-148, 1995
6. Hendriks A, Heyns W, De Moor P: Influence of a low-calorie diet and fasting on the metabolism of dehydroepiandrosterone sulfate in adult obese subjects. J Clin Endocrinol Metab 28:1525-1533, 1968
7. Kask E: 17-ketosteroids and atherosclerosis. Angiology 10:358-368, 1959
8. Feldman HA, Johannes CB, McKinlay RK, et al: Low dehydroepiandrosterone sulfate and heart disease in middle-aged men: Cross-sectional results from the Massachussetts Male Aging Study. Ann Epidemiol 8:217-228, 1998
9. Barrett-Connor E, Khaw KT, Yen SS: A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease. N Engl J Med 315:1519-1524, 1986
10. Rosenbaum M, Nicolson M, Hirsch J, et al: Effects of weight change on plasma leptin concentrations and energy expenditure. J Clin Endocrinol Metab 82:3647-3654, 1997
11. Ma ZA, Gingerich RI, Santiago J, et al: Radioimmunoassay of leptin in human plasma. Clin Chem 42:942-946, 1996
12. Haffner SM, Stern MP, Miettinen H, et al: Leptin concentrations in diabetic and nondiabetic Mexican-Americans. Diabetes 45:822-824, 1996
13. Banerji MA, Faridi N, Atluri R, et al: Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men. J Clin Endocrinol Metab 84:137-144, 1999
14. Igel M, Lindethal B, Giesa U, et al: Evidence that leptin contributes to intestinal cholesterol absorption in obese (Ob/ob) mice and wild-type mice. Lipids 37:153-157, 2002
15. Konstantinides S, Schafer K, Koschnick S, et al: Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 108:1533-1540, 2001
16. Mazzaferri EL: Management of a solitary thyroid nodule. N Engl J Med 328:553-559, 1993
17. Stamler J, Daviglus ML, Garside DB, et al: Relationship of baseline serum cholesterol levels in 3 large cohorts of younger men to long-term coronary, cardiovascular, and all-cause mortality and to longevity. JAMA 84:311-318, 2000
18. Johannes CB, Stellato RK, Feldman HA, et al: Relation of dehydroepiandrosterone and dehydroepiandrosterone sulfate with cardiovascular disease risk factors in women: Longitudinal results from the Massachusetts women's health study. J Clin Epidemiol 52:95-103, 1999
19. Tchernof A, Despres JP, Belanger A, et al: Reduced testosterone and adrenal C19 steroid levels in obese men. Metabolism 44:513-519, 1995
20. De Pergola G, Giagulli VA, Garruti G, et al: Low dehydroepiandrosterone circulating levels in premenopausal obese women with very high body mass index. Metabolism 40:187-190, 1991
21. Azziz R, Zacur HA, Parker CR, et al: Effect of obesity on the response to acute adrenocorticotropin stimulation in eumenorrheic women. Fertil Steril 56:427-433, 1991
22. Barrett-Connor E, Ferrara A: Dehydroepiandrosterone, dehydroepiandrosterone sulfate, obesity, waist-hip ratio, and noninsulin-dependent diabetes in postmenopausal women: The Rancho Bernardo Study. J Clin Endocrinol Metab 81:59-64, 1996
23. Maccario M, Mazza E, Ramunni J, et al: Relationships between dehydroepiandrosterone-sulphate and anthropometric, metabolic and hormonal variables in a large cohort of obese women. Clin Endocrinol (Oxf) 50:595-600, 1999
24. Kirschner MA, Samojlik E, Silber D: A comparison of androgen production and clearance in hirsute and obese women. J Steroid Biochem Mol Biol 19:607-614, 1983
25. Farah MJ, Givens JR, Kitabchi AE: Bimodal correlation between the circulating insulin level and the production rate of dehydroepiandrosterone: Positive correlation in controls and negative correlation in the polycystic ovary syndrome with acanthosis nigricans. J Clin Endocrinol Metab 70:1075-1081, 1990
26. Kurtz BR, Givens JR, Komindr S, et al: Maintenance of normal circulating levels of delta 4-androstenedione and dehydroepiandrosterone in simple obesity despite increased metabolic clearance rates: Evidence for a servo-control mechanism. J Clin Endocrinol Metab 64:1261-1267, 1987
27. Feher T, Halmy L: Dehydroepiandrosterone and dehydroepiandrosterone sulfate dynamics in obesity. Can J Biochem 53:215-222, 1975
28. 14C] dehydroepiandrosterone and [7 α-3H] dehydroepiandrosterone sulphate metabolites in urine of normal and obese female subjects. Endocrinology 67:184-191, 1986
29. Mortola J, Yen SSC: The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women. J Clin Endocrinol Metab 71:696-704, 1990
30. Nestler JE, Barlascini CO, Clore JN, et al: Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men. J Clin Endocrinol Metab 66:57-61, 1988
31. Haffner SM, Mykkänen L, Valdez RA, et al: Relationship of sex hormone to lipids and lipoproteins in nondiabetic men. J Clin Endocrinol Metab 77:1610-1615, 1993
32. Nagata C, Takatsuka N, Kabuto M, et al: Association of dehydroepiandrosterone sulfate with serum HDL-cholesterol concentrations in post-menopausal Japanese women. Maturitas 31:21-27, 1998