Penetration of topically applied ciprofloxacin and ofloxacin into the aqueous humor and vitreous

Journal of Cataract and Refractive Surgery

Volumn 29, Issue 3, 2003, Pages 487-491

  Yalvac, Ilgaz Sagdic ^a,b   Basci, Nursabah E ^b   Bozkurt, Atila ^b   Duman, Sunay ^b  

^a Cankaya 06690   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CIPROFLOXACIN; EXOCIN; OFLOXACIN; ANTIINFECTIVE AGENT;

ADULT; AGED; AQUEOUS HUMOR; ARTICLE; BACTERIAL INFECTION; BACTERICIDAL ACTIVITY; CATARACT EXTRACTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORNEA EPITHELIUM; DRUG PENETRATION; DRUG TISSUE LEVEL; EYE INFECTION; FEMALE; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MALE; MINIMUM INHIBITORY CONCENTRATION; PRIORITY JOURNAL; RANDOMIZATION; STATISTICAL SIGNIFICANCE; VITREOUS BODY; BACTERIUM; BIOAVAILABILITY; COMPARATIVE STUDY; CORNEA; DRUG EFFECT; METABOLISM; MICROBIOLOGICAL EXAMINATION; MIDDLE AGED; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; AGED; ANTI-INFECTIVE AGENTS; AQUEOUS HUMOR; BACTERIA; BIOLOGICAL AVAILABILITY; CATARACT EXTRACTION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIPROFLOXACIN; CORNEA; FEMALE; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; OFLOXACIN; PROSPECTIVE STUDIES; VITREOUS BODY;

EID: 0037352920     PISSN: 08863350     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0886-3350(02)01538-9     Document Type: Article

References (20)

1. Cokingtin CD, Hyndiuk RA. Insights from experimental data on ciprofloxacin in the treatment of bacterial keratitis and ocular infections. Am J Ophthalmol 1991; 112(ciprofloxacin suppl):25S-28S
2. McDermott ML, Tran TD, Cowden JW, Bugge CJL. Corneal stromal penetration of topical ciprofloxacin in humans. Ophthalmology 1993; 100:197-200
3. Diamond JP, White L, Leerning JP, et al. Topical 0.3% ciprofloxacin, norfloxacin and ofloxacin in the treatment of bacterial keratitis: a new method for comparative evaluation of ocular drug penetration. Br J Ophthalmol 1995; 79:606-609
4. Donnenfeld ED, Schrier A, Perry HD, et al. Penetration of topically applied ciprofloxacin, norfloxacin, and ofloxacin into the aqueous humor. Ophthalmology 1994; 101:902-905
5. Lesk MR, Ammann H, Marcil G, et al. The penetration of oral ciprofloxacin into the aqueous humor, vitreous, and subretinal fluid of humans. Am J Ophthalmol 1993; 115:623-628
6. Kalayci D, Basci N, Akpek E, et al. Penetration of topical 0.3% ciprofloxacin into human aqueous humor. Ophthalmic Surg Lasers 1996; 27:21-24
7. Fern AI, Sweeney G, Doig M, Lindsay G. Penetration of ciprofloxacin into aqueous humor. Trans Ophthalmol Soc UK 1986; 105:650-652
8. Skoutelis AT, Gartaganis SP, Chrysanthopoulos CJ, et al. Aqueous humor penetration of ciprofloxacin in the human eye. Arch Ophthalmol 1988; 106:404-405
9. Giamarellou H, Kanellas D, Kavouklis E, et al. Comparative pharmacokinetics of ciprofloxacin, ofloxacin and perfloxacin in human aqueous humour. Eur J Clin Microbiol Infect Dis 1993; 12:293-297
10. Kowalski RP, Karenchak LM, Eller AW. The role of ciprofloxacin in endophthalmitis therapy. Am J Ophthalmol 1993; 116:695-699
11. Behrens-Baumann W. Absorption of topically administered ciprofloxacin, ofloxacin and gentamicin in the inflamed rabbit eye. Ophthalmologica 1996; 210:119-122
12. Pearson PA, Hainsworth DP, Ashton P. Clearance and distribution of ciprofloxacin after intravitreal injection. Retina 1993; 13:326-330
13. Basci NE, Bozkurt A, Kalayci D, Kayaalp SO. Rapid liquid chromatographic assay of ciprofloxacin in human aqueous humor. J Pharm Biomed Anal 1996; 14:353-356
14. Borrmann LR, Leopold IH. The potential use of quinolones in future ocular antimicrobial therapy [editorial]. Am J Ophthalmol 1988; 106:227-229
15. Cekic O, Batman C, Yasar O, et al. Penetration of ofloxacin in human aqueous and vitreous humors following oral and topical administration. Retina 1998; 18:521-525
16. Ross DL, Riley CM. Aqueous solubilities of some variously substituted antimicrobials. Int J Pharm 1990; 63:237-250
17. Han DP, Wisniewski SR, Wilson LA. Spectrum and susceptibilities of microbiologic isolates in the Endophthalmitis Vitrectomy Study; the Endoththalmitis Vitrectomy Study Group. Am J Ophthalmol 1996; 122:1-17
18. El Baba FZ, Trousdale MD, Gauderman WJ, et al. Intravitreal penetration of oral ciprofloxacin in humans. Ophthalmology 1992; 99:483-486
19. Çekiç O, Batman C, Yasar Ü, et al. Comparison of aqueous humour and vitreous humour levels of two 0.3% ciprofloxacin eyedrops. Can J Ophthalmol 1998; 33:373-376
20. Neu HC. The quinolones. Infect Dis Clin North Am 1989; 3:625-639