Major intermediates in organophosphate synthesis (PCl3, POCl3, PSCl3, and their diethyl esters) are anticholinesterase agents directly or on activation

Chemical Research in Toxicology

Volumn 16, Issue 3, 2003, Pages 350-356

  Segall, Yoffi ^a,b   Quistad, Gary B ^a   Sparks, Susan E ^a   Casida, John E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; CARBOXYLESTERASE; CHOLINESTERASE INHIBITOR; CHYMOTRYPSIN A; DIETHOXYPHOSPHOCHLORIDE; FLAME RETARDANT; FLUORIDE; FLUOROPHOSPHATE; ORGANOPHOSPHATE; ORGANOPHOSPHATE INSECTICIDE; ORGANOPHOSPHATE PESTICIDE; PHOSPHORUS OXYCHLORIDE; PHOSPHORUS SULFOCHLORIDE; PHOSPHORUS TRICHLORIDE; SERINE DEHYDRATASE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CHEMICAL WARFARE; CHOLINESTERASE INHIBITION; ENZYME ASSAY; ENZYME SPECIFICITY; HOUSE FLY; HUMAN; HUMAN TISSUE; HYDROLYSIS; INHALATION; LD 50; MALE; MOUSE; NONHUMAN; OXIDATION; PEST CONTROL; RAT; SYNTHESIS; TOXICITY TESTING; VAPOR;

ACETYLCHOLINESTERASE; ANIMALS; BRAIN; BUTYRYLCHOLINESTERASE; CATTLE; CHOLINESTERASE INHIBITORS; DOGS; ENZYME ACTIVATION; ESTERS; HOUSEFLIES; HUMANS; HYDROCARBONS, CHLORINATED; HYDROLYSIS; INHIBITORY CONCENTRATION 50; INSECTICIDES; LETHAL DOSE 50; MICE; ORGANOPHOSPHORUS COMPOUNDS; OXIDATION-REDUCTION; PHOSPHORUS COMPOUNDS; PHOSPHORYLATION; SERINE ENDOPEPTIDASES;

ANIMALIA; MAMMALIA; MUSCA DOMESTICA;

EID: 0037352126     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx020094l     Document Type: Article

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