Treatment of ventilator-associated pneumonia: Get it right from the start

Critical Care Medicine

Volumn 31, Issue 3, 2003, Pages 969-970

  Kollef, Marin H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anti microbial resistance; Antibiotics; Bacteria; Outcome; Pneumonia

Indexed keywords

ANTIBIOTIC AGENT;

ANTIBIOTIC THERAPY; ARTIFICIAL VENTILATION; EDITORIAL; ENTEROBACTERIACEAE; HUMAN; INTENSIVE CARE; LUNG INFECTION; MORTALITY; PNEUMONIA; PRACTICE GUIDELINE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

ALGORITHMS; ANTI-BACTERIAL AGENTS; BLOOD GAS ANALYSIS; CROSS INFECTION; DECISION TREES; HUMANS; PATIENT SELECTION; PNEUMONIA; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RESPIRATION, ARTIFICIAL; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 0037351607     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000055381.70829.94     Document Type: Editorial

References (20)

1. Luna CM, Blanzaco D, Niederman MS et al: Resolution of ventilator-associated pneumonia: Prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcome. Crit Care Med 2003; 31:676-682
2. Pugin J, Auckenthaler R, Mili N, et al: Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lavage fluid. Am Rev Respir Dis 1991; 143:1121-1129
3. Alvarez-Lerma F: Modifications of empiric antibiotic treatment in patients with pneumonia acquired in the intensive care unit: ICU-Acquired Pneumonia Study Group. Intensive Care Med 1996; 22:387-394
4. Luna CM, Vujachich P, Neiderman MS, et al: Impact of BAL data on the therapy and outcome of ventilator-associated pneumonia. Chest 1997; 111:676-685
5. Rello J, Gallego M, Mariscal D, et al: The value of routine microbial investigation in ventilator-associated pneumonia. Am J Respir Crit Care Med 1997; 156:196-200
6. Heyland DK, Cook DJ, Griffith L, et al: The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient. Am J Respir Crit Care Med 1999; 159:1249-1256
7. Kollef MH, Ward S: The influence of mini-BAL cultures on patient outcomes. Implications for the antibiotic management of ventilator-associated pneumonia. Chest 1998; 113:412-420
8. Leibovici L, Shraga I, Drucker M, et al: The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection. J Intern Med 1998; 244:379-386
9. Schiappa DA, Hayden MK, Matushek MG, et al: Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli bloodstream infection: A case-control and molecular epidemiologic investigation. J Infect Dis 1996; 174:529-536
10. Weinstein MP, Towns ML, Quartey SM, et al: The clinical significance of positive blood cultures in the 1990s: A prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis 1997; 24:584-602
11. Vidal F, Mensa J, Almela M, et al: Epidemiology and outcome of Pseudomonas aeruginosa bacteremia, with special emphasis on the influence of antibiotic treatment. Analysis of 189 episodes. Arch Intern Med 1996; 156:2121-2126
12. Bryan CS, Reynolds KL, Brenner ER: Analysis of 1186 episodes of Gram-negative bacteremia in non-university hospitals: The effects of antimicrobial therapy. Rev Infect Dis 1983; 5:629-638
13. Chow JW, Fine MJ, Shlaes DM, et al: Enterobacter bacteremia: Clinical features and emergence of antibiotic resistance during therapy. Ann Intern Med 1991; 115:585-590
14. Meehan TP, Fine MJ, Krumholz HM, et al: Quality of care, process, and outcomes in elderly patients with pneumonia. JAMA 1997; 278:2080-2084
15. Dean NC, Silver MP, Bateman KA, et al: Decreased mortality after implementation of a treatment guideline for community-acquired pneumonia. Am J Med 2002; 110:451-457
16. Iregui M, Ward S, Sherman G, et al: Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest 2002; 122:262-268
17. Kollef MH: Inadequate antimicrobial treatment: An important determinant of outcome for hospitalized patients. Clin Infect Dis 2000; 31:S131-S138
18. Singh N, Rogers P, Atwood CW, et al: Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. A proposed solution for indiscriminate antibiotic prescription. Am J Respir Crit Care Med 2000; 162:505-511
19. Ibrahim EH, Ward S, Sherman G, et al: Experience with a clinical guideline for the treatment of ventilator-associated pneumonia. Crit Care Med 2001; 29:1109-1115
20. Dennesen PJW, van der Ven AJAM, Kessels MH, et al: Resolution of infectious parameters after antimicrobial therapy in patients with ventilator-associated pneumonia. Am J Respir Crit Care Med 2001; 163:1371-1375