Biotransformations of the cardiovascular drugs mexrenone and canrenone

Journal of Natural Products

Volumn 66, Issue 3, 2003, Pages 350-356

  Preisig, Carol L ^a,c   Laakso, Jodi A ^a,d   Mocek, Ursula M ^a,d   Wang, Ping T ^b   Baez, Julio ^b,e   Byng, Graham ^a  

^a MDS Inc   (Canada)

^b PFIZER INC   (United States)

^c DIVERSA CORPORATION   (United States)

^d ALBANY MOLECULAR RESEARCH INC   (United States)

^e FIBROGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

11ALPHA HYDROXYMEXRENONE; 12BETA HYDROXYMEXRENONE; 6BETA HYDROXYMEXRENONE; 9ALPHA HYDROXYCANRENONE; CANRENONE; CANRENONE DERIVATIVE; MEXRENONE; UNCLASSIFIED DRUG;

ARTICLE; BEAUVERIA; BIOTRANSFORMATION; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ISOLATION; DRUG METABOLISM; DRUG POTENCY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MORTIERELLA; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET IRRADIATION;

BIOTRANSFORMATION; CANRENONE; CARDIOVASCULAR AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FERMENTATION; FUNGI; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; MORTIERELLA; SPIRONOLACTONE; STEREOISOMERISM;

BASSIANA; BEAUVERIA; CORDYCEPS BASSIANA; CORYNESPORA CASSIICOLA; MORTIERELLA; UMBELOPSIS ISABELLINA;

EID: 0037351290     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np020347a     Document Type: Article

References (11)

1. Weier, R. M.; Hofmann, L. M. J. Med. Chem. 1975, 18, 817-821.
2. Weier, R. M.; Hofmann, L. M. J. Med. Chem. 1977, 20, 1304-1308.
3. (a) Ng, J. S.; Wang, P. T.; Baez, J. S.; Liu, C.; Anderson, D. K.; Lawson, J.; Erb, D.; Wieczorek, J.; Mucciariello, G.; Vanzella, F.; Kunda, S. A.; Letendre, L. J.; Pozzo, M. J.; Sing, Y.-L. WO Patent 97/21720, 1997.
4. (b) Ng, J. S.; Liu, C.; Anderson, D. K.; Lawson, J.; Wieczorek, J.; Kunda, S. A.; Letendre, L. J.; Pozzo, M. J.; Sing, Y.-L.; Wang, P. T.; Yonan, E. E.; Weier, R. M.; Kowar, T. R.; Baez, J. S.; Erb, D. WO Patent 98/25948, 1998.
5. Preisig, C. L.; Laakso, J.; Mocek, U.; Wang, P.; Ng, J.; Baez, J.; Byng, G. S. Advances in Biocatalysis Symp., 216th ACS National Meeting, Boston; Aug 23-27, 1998. BTEC-059.
6. (a) Smith, K.; Latif, S.; Kirk, D. N.; White, K. A. J. Steroid Biochem. 1989, 33, 271-276.
7. (b) Smith, K.; Latif, S.; Kirk, D. N. J. Steroid Biochem. 1989, 33, 927-934.
8. Highet, R. J.; Burke, T. R.; Trager, W. F.; Pohl, L. R.; Menard, R. H.; Taburet, A. M.; Gillette, J. R. Steroids 1980, 35, 119-132.
9. Schubert, A.; Heller, K.; Onken, D.; Schwarz, S.; Siebert, R.; Zaumseil, J. Z. Chem. 1962, 2, 289-297.
10. Schering, A. G. JP Patent 80,77,897, 1980.
11. Wang, P. T.; Baez, J. Personal communication.