A miniaturized matrix-assisted laser desorption/ionization time of flight mass spectrometer with mass-correlated acceleration focusing

Journal of Mass Spectrometry

Volumn 38, Issue 3, 2003, Pages 296-304

  English, Robert D ^a   Cotter, Robert J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Field application; Mass correlated acceleration focusing; Miniaturized matrix assisted laser desorption ionization time of flight mass spectrometer; Peptides; Proteins

Indexed keywords

DESORPTION; EXTRACTION; IONIZATION; LASER APPLICATIONS; PROTEINS;

PULSED EXTRACTION METHODS;

MASS SPECTROMETERS;

ION; PEPTIDE; PROTEIN;

ACCELERATION; ANALYTICAL EQUIPMENT; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; EQUIPMENT DESIGN; EXTRACTION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MULTICHANNEL RECORDER; PRIORITY JOURNAL; PROTEIN DEGRADATION; VALIDATION PROCESS;

ACCELERATION; AMINO ACID SEQUENCE; ANGIOTENSIN II; ANIMALS; CATTLE; MINIATURIZATION; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MURAMIDASE; PEPTIDE FRAGMENTS; SENSITIVITY AND SPECIFICITY; SERUM ALBUMIN, BOVINE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS;

EID: 0037350723     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/jms.441     Document Type: Article

References (33)

1. Badman ER, Cooks G. Miniature mass analyzers. J. Mass Spectrom. 2000; 35: 659.
2. Palmer PT, Limero TF. Mass spectrometry in the U.S. space program: past, present, and future. J. Am. Soc. Mass Spectrom. 2001; 12: 656.
3. Eckenrode BA. Environmental and forensic applications of field-portable GC-MS: an overview. J. Am. Soc. Mass Spectrom. 2001; 12: 683.
4. Cotter RJ, Fancher C, Cornish TJ. Miniaturized time-of-flight mass spectrometer for peptide and oligonucleotide analysis. J. Am. Soc. Mass Spectrom. 1999; 34: 1368.
5. Cotter RJ, Cornish TJ. High-order kinetic energy focusing in an end cap reflectron time-of-flight mass spectrometer. Anal. Chem. 1997; 69: 4615.
6. Short RT, Fries DP, Kerr ML, Lembke CE, Toler SK, Wenner PG, Byrne RH. Underwater mass spectrometers for in situ chemical analysis of the hydrosphere. J. Am. Soc. Mass Spectrom. 2001; 12: 676.
7. Syage JA, Nies BJ, Evans MD, Hanold KA. Field-portable, high-speed GC /TOFMS. J. Am. Soc. Mass Spectrom. 2001; 12: 648.
8. Diaz JA, Giese CF, Gentry WR. Sub-miniature ExB sector-field mass spectrometer. J. Am. Soc. Mass Spectrom. 2001; 12: 619.
9. Berkout VD, Cotter RJ, Segers DP. Miniaturized EI/Q/oa TOF mass spectrometer. J. Am. Soc. Mass Spectrom. 2001; 12: 641.
10. Karas M, Bachmann D, Bahr U, Hillenkamp F. Matrix-assisted ultraviolet laser desorption of non-volatile compounds. Int. J. Mass Spectrom. Ion Processes 1987; 78: 53.
11. Tanaka K, Ido Y, Akita S. In Proceedings of the Second Japan-China Joint Symposium on Mass Spectrometry, Matsuda H, Liang X-T. (eds). Bango: Osaka, 1987; 185-188.
12. Cotter RJ. Time-of-Flight Mass Spectrometry: Instrumentation and Applications in Biological Research. American Chemical Society: Washington, DC, 1997.
13. Wiley WC, McLaren IH. Mass spectrometer with improved resolution. Rev. Sci. Instrum. 1955; 26:1150.
14. Colby SM, King TB, Reilly JP. Improving the resolution of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry by exploiting the correlation between ion position and velocity. Rapid Commun. Mass Spectrom. 1994; 8: 865.
15. Brown RS, Lennon JJ. Mass resolution improvement by incorporation of pulsed ion extraction in a matrix-assisted laser desorption/ionization linear time-of-flight mass spectrometer. Anal. Chem. 1995; 67: 1998.
16. Vestal ML, Juhasz P, Martin SA. Delayed extraction matrix-assisted laser desorption time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 1995; 9: 1044.
17. Whittal RM, Li L. High-resolution matrix-assisted laser desorption/ionization in a linear time-of-flight mass spectrometer. Anal. Chem. 1995; 67: 1950.
18. Vestal ML, Juhasz P. Resolution and mass accuracy in matrix-assisted laser desorption ionization-time-of-flight. J. Am. Soc. Mass Spectrom. 1998; 9: 892.
19. Whittal RM, Russon LM, Weinberger SR, Li L. Functional wave time-lag focusing matrix-assisted laser desorption/ionization in a linear time-of-flight mass spectrometer: improved mass accuracy. Anal. Chem. 1997; 69: 2147.
20. Franzen J. Improved resolution for MALDI-TOF mass spectrometers: a mathematical study. Int. J. Mass Spectrom. Ion Processes 1997; 164: 19.
21. Muga ML. US Patent 4 458 149, 1984.
22. Yefchak GE, Enke CG, Holland JF. Models for mass-independent space and energy focusing in time-of-flight mass spectrometry. Int. J. Mass Spectrom. Ion Processes 1989; 87: 313.
23. Kinsel GR, Johnston MV. Post source pulse focusing: a simple method to achieve improved resolution in a time-of-flight mass spectrometer. Int. J. Mass Spectrom. Ion Processes 1989; 91: 157.
24. Kinsel GR, Grundwuermer JM, Grotemeyer J. J. Am. Soc. Mass Spectrom. 1993; 4: 2.
25. Kovtoun SV. An approach to the design of mass-correlated delayed extraction in a linear time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom. 1997; 11: 433.
26. Kovtoun SV. Mass-correlated delayed extraction in linear time-of-flight mass spectrometers. Rapid Commun. Mass Spectrom. 1997; 11: 810.
27. Kovtoun SV, Cotter RJ. Mass-correlated pulsed extraction: theoretical analysis and implementation with a linear matrix-assisted laser desorption/ionization time of flight mass spectrometer. J. Am. Soc. Mass Spectrom. 2000; 11: 841.
28. Kovtoun SV, English RD, Cotter RJ. Mass correlated acceleration in a reflectron MALDI TOF mass spectrometer: an approach for enhanced resolution over a broad mass range. J. Am. Soc. Mass Spectrom. 2002; 13: 135.
29. Beavis RC, Chait BT. Rapid, sensitive analysis of protein mixtures by mass spectrometry. Proc. Natl. Acad. Sci. USA 1990; 87: 6873-6877.
30. Bai J, Liu YH, Cain TC, Lubman DM. Matrix-assisted laser desorption/ionization using an active perfluorosulfonated ionomer film substrate. Anal. Chem. 1994; 66: 3423.
31. Wu KJ, Steding A, Becker CH. Matrix-assisted laser desorption time-of-flight mass spectrometry of oligonucleotides using 3-hydroxypicolinic acid as an ultraviolet-sensitive matrix. Rapid Commun. Mass Spectrom. 1993; 7: 142.
32. Bowdler AR, Cotter RJ, Kovtoun SV. Combining mass correlated acceleration and a curved field reflectron. In Proceedings of the 49th ASMS Conference on Mass Spectrometry and Allied Topics, Chicago, IL, May 27-31, 2001; electronic proceedings.
33. Prieto MC, Kovtoun VV, Cotter RJ. Miniaturized linear time-of-flight mass spectrometer with pulsed extraction. J. Mass Spectrom. in press.