Toluene inhalation induced 8-hydroxy-2′-deoxyguanosine formation as the peroxidative degeneration in rat organs

Legal Medicine

Volumn 5, Issue 1, 2003, Pages 34-41

  Tokunaga, Itsuo ^a   Gotohda, Takako ^a   Ishigami, Akiko ^a   Kitamura, Osamu ^a   Kubo, Shin Ichi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

8 Hydroxy 2 deoxyguanosine; Lipid peroxide; Peroxidative damage; Superoxide dismutase; Toluene

Indexed keywords

4 HYDROXYNONENAL; 8 HYDROXYDEOXYGUANOSINE; LIPID PEROXIDE; SUPEROXIDE DISMUTASE; TOLUENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; GENETIC MARKER; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INHALATION; KIDNEY; LIVER; LUNG; MALE; NONHUMAN; OXIDATIVE STRESS; PEROXIDATION; QUANTITATIVE ANALYSIS; RAT; RAT STRAIN; SPERMATOGONIUM; TESTIS;

EID: 0037348384     PISSN: 13446223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1344-6223(03)00004-X     Document Type: Article

References (21)

1. Ostergaard G, Hass U, Lund SP, Simonsen L. Four weeks' inhalation exposure of Long Evans rats to 4-tert-butyltoluene: Effect on evoked potentials, behaviour, and brain neurochemistry. Pharmacol Toxicol 2000;87(1):11-17.
2. Hass U, Lund SP, Hougaard KS, Simonsen L. Developmental neurotoxicity after toluene inhalation exposure in rats. Neurotoxicol Teratol 1999;21(4):349-57.
3. Tomas T, Wiaderna D, Swiercz R. Neurotoxicity assessment of selected organic solvents based on spontaneous and evoked cortical and hippocampal activity in rats. Int J Occup Med Environ Health 1999;12(1):73-84.
4. Cintra A, Andbjer B, Finnman UB, Hagman M, Agnati LF, Hoglund G, Fuxe K. Subacute toluene exposure increases DA dysfunction in the 6-OH dopamine lesioned nigrostriatal dopaminergic system of the rat. Neurosci Lett 1996;217(1):61-5.
5. De Gandarias JM, Echevarria E, Serrano R, Irazusta J, Casis L. Effect of subacute toluene administration on the enkephalinergic neuromodulatory system in rats and protective action of ganglioside treatments. Toxicol Ind Health 1994;10(3):155-61.
6. Gotohda T, Kuwada A, Morita K, Kubo S, Tokunaga I. Elevation of steroid 5α-reductase mRNA levels in rat cerebellum by toluene inhalation: Possible relation to GFAP expression. J Toxicol Sci 2000;25(3):223-31.
7. Gotohda T, Tokunaga I, Kubo S, Morita K, Kitamura O, Eguchi A. Effect of toluene inhalation on astrocytes and neurotrophic factor in rat brain. Forensic Sci Int 2000;113(1-3):233-8.
8. Gotohda T, Tokunaga I, Kubo S, Morita K. Enhancement of glial cell line-derived neurotrophic factor expression in rat adrenal glands by toluene exposure. Horm Metab Res 2000;32(8):301-5.
9. Ohkuma Y, Hiraku Y, Oikawa S, Yamashita N, Murata M, Kawanishi S. Distinct mechanisms of oxidative DNA damage by two metabolites of carcinogenic o-toluidine. Arch Biochem Biophys 1999;372(1):97-106.
10. Murata M, Tsujikawa M, Kawanishi S. Oxidative DNA damage by minor metabolites of toluene may lead to carcinogenesis and reproductive dysfunction. Biochem Biophys Res Commun 1999;261(2):478-83.
11. Anderson KM, Ou D, Wu YB, Jajeh A, Harris JE. Induction of type 1 programmed cell death in U937 cells by the antioxidant, butylated hydroxy-toluene or the free radical spin trap, NTBN. Leuk Res 1999;23(7):665-73.
12. Liu L, Zhang Q, Feng J, Deng L, Zeng N, Yang A, Zhang W. The study of DNA oxidative damage in benzene-exposed workers. Mutat Res 1996;370(3-4):145-50.
13. Carere A, Antoccia A, Crebelli R, Di Chiara D, Fuselli S, Iavarone I, Isacchi G, Lagorio S, Leopardi P, Marcon F. Exposure to benzene and genotoxic effects among filling station attendants. Epidemiol Prev 1995;19(62):105-19.
14. Lagorio S, Tagesson C, Forastiere F, Iavarone I, Axelson O, Carere A. Exposure to benzene and urinary concentrations of 8-hydroxydeoxyguanosine, a biological marker of oxidative damage to DNA. Occup Environ Med 1994;51(11):739-43.
15. Ahmed-Choudhury J, Orsler DJ, Coleman R. Hepatobiliary effects of tertiary-butylhydroperoxide (tBOOH) in isolated rat hepatocyte couplets. Toxicol Appl Pharmacol 1998;152(1):270-5.
16. Agar NS, Mahoney Jr JR, Eaton JW. Hemolytic and microbicidal actions of diethyldithiocarbamic acid. Biochem Pharmacol 1991;41(6-7):985-93.
17. Weisiger RA, Fridovich I. Mitochondrial superoxide dismutase. Site of synthesis and intramitochondrial localization. J Biol Chem 1973;248:4793-6.
18. Carlsson LM, Jonsson J, Edlund T, Marklund L. Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia. Proc. Natl. Acad Sci USA 1995;92:6264-8.
19. Maki H, Sekiguchi M. Mut T protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature 1992;355:273-5.
20. Brozovsky M, Winkler EG. Glue sniffing in children and adolescents. N Y State J Med 1965;65:1984-9.
21. Carlsson A, Lindqvist T. Exposure of animals and man to toluene. Scand J Work Environ Health 1977;3:135-43.