The LONFLIT4-Venoruton study: A randomized trial - Prophylaxis of flight-edema in venous patients

Angiology

Volumn 54, Issue 2, 2003, Pages 137-142

  Cesarone, Maria Rosaria ^a   Belcaro, Gianni ^a   Brandolini, Rossella ^a   Di Renzo, Andrea ^a   Bavera, Pietro ^a   Dugall, Mark ^a   Simeone, Emilio ^a   Acerbi, G ^a   Ippolito, Edmondo ^a   Winford, Michelle ^a   Candiani, Carlo ^a   Golden, Gerard ^a   Ricci, Andrea ^a   Stuard, Stefano ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

LOW MOLECULAR WEIGHT HEPARIN; MONOXERUTIN; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG TOLERABILITY; EDEMA; FEMALE; FLIGHT; FLUID BALANCE; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL CARE; MICROCIRCULATION; PATIENT COMPLIANCE; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; THROMBOEMBOLISM; VEIN DISEASE; VISUAL ANALOG SCALE;

EID: 0037345989     PISSN: 00033197     EISSN: None     Source Type: Journal    
DOI: 10.1177/000331970305400201     Document Type: Article

References (32)

1. Geroulakos G, Hossain J, Tran T: Economy-class syndrome presenting as phlegmasia caerulea dolens. Eur J Vasc Endovasc Surg 20:102-104, 2000
2. Perry K: Blood clot kills woman after flight. Guardian 23 Oct, 2001.
3. Homans J: Thrombosis of the deep leg veins due to prolonged sitting. N Engl J Med 250:148-149, 1954.
4. Symington IS, Stack BHR: Pulmonary thromboembolism after travel. Br J Chest 17:138-140; 1977.
5. Simpson K: Shelter deaths from pulmonary embolism. Lancet 11:744, 1940.
6. Ferrari E, Chevallier T, Chapelier A, et al: Travel as a risk factor for venous thromboembolic disease: A case control study. Chest 115:440-444, 1999.
7. Cruickshank JM, Gorlin R, Jennett B: Air travel and thrombotic episodes: The economy class syndrome. Lancet 2:497-498; 1988.
8. Kraaijenhagen R, Haverkamp D, Koopman MMW, et al: Travel and risk of venous thrombosis. Lancet 356:1492-1493, 2000.
9. Sarvesvaran R: Sudden natural deaths associated with commercial air travel. Med Sci Law 26:35-38, 1986.
10. Landgraf H, Vanselow B, Schulte-Huerman D, et al: Economy class syndrome: Rheology fluid balance and lower leg oedema during a simulated 12-hour long-distance flight. Aviat Space Envir Med 65:930-935, 1994.
11. AMA Commission on Emergency Services: Medical aspects of transportation aboard commercial aircraft. JAMA 247:1007-1011, 1982.
12. Gertler JP, Perry L, L'Italien G, et al: Ambient oxygen tension modulates endothelial fibrinolysis. J Vasc Surg 18:939-946, 1993.
13. Bendz B, Rostrup M, Sevre K, et al: Association between acute hypobaric hypoxia and activation of coagulation in human beings. Lancet 356:1657-1658, 2000.
14. Belcaro G, Geroulakos G, Nicolaides AN, et al: Venous thromboembolism from air travel. The Lonflit Study. Angiology 52:369-374, 2001.
15. Belcaro G, Geroulakos G, Nicolaides AN, et al: Maladie veineuse thrombo-embolique apres vol aerien. Les etudes LONFLIT. Angeiologie 53:17-21, 2001.
16. Cesarone MR, Belcaro G, Nicolaides AN, et al: Venous thromboembolism from air travel: The Lonflit3 study. Prevention with aspirin vs low-molecular-weight heparin (LMWH) in high-risk subjects: A randomized trial. Angiology 52:1-6, 2002.
17. Scurr JH, Machin SJ, Bayley S, et al: Frequency and prevention of symptomless deep-vein thrombosis in long-haul flights: A randomized trial. Lancet 357:1485-1489, 2001.
18. Cesarone MR, Belcaro G, Geroulakos G, et al: Flight microangiopathy in medium-to-long distance flights: Prevention of edema and microcirculation alterations with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides: A prospective-randomized, controlled trial. J Cardiovasc Pharmacol Ther 7(suppl I):S17-S20, 2002.
19. Belcaro G, Nicolaides AN: Noninvasive Investigations in Vascular Disease. London: Imperial College Press, 2000.
20. Belcaro G, Stansby G, Nicolaides AN: The Venous Clinic. London: Imperial College Press, 1999.
21. Thulesius O: Chronic venous insufficiency and varicose veins physiopathological view points. Lakartidningen. 80:1791-1801, 1983.
22. Belcaro G, Hoffman U, Bollinger A, et al: Laser Doppler. London: Med-Orion, 1996.
23. Cesarone MR, Belcaro G, Nicolaides AN, et al: The edema tester in the evaluation of swollen limbs in venous and lymphatic disease. Panmin Med 41:10-14, 1999.
24. Webster B: Airlines tell passengers to stretch legs. London Times, Jan 12, 2001.
25. Geroulakos G: The risk of venous thromboembolism from air travel. The evidence is only circumstantial (editorial). BMJ 322:188, 2001.
26. Calder S: Exercise your constitutional rights in the air. The Independent, Jan 13, 2001.
27. The fit flyer. High Life magazine. Dec 2000.
28. Data from USA Today research, 2000.
29. James J: Perils of passage. Time, pp 54-59, 2001.
30. Eklof B: Report from the WHO meeting in Geneva, March 2001 (unpublished, manuscript in preparation).
31. Cesarone MR, Meli E: Volare con Sicurezza. Jet-leg. Il problema dell'edema e della trombosi in voli di lunga durata. Ediz Minerva Medica, Turin 2001.
32. Nicolaides AN: Investigation of chronic venous insufficiency: A consensus statement. Circulation 102: e126-163, 2000.