Anti-neutrophil cytoplasm antibody associated vasculitis

International Journal of Biochemistry and Cell Biology

Volumn 35, Issue 3, 2003, Pages 277-282

  Hewins, Peter ^a   Savage, Caroline ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Anti neutrophil cytoplasm antibodies (ANCA); Autoantibodies; Leukocyte autoantibody interactions

Indexed keywords

15 DEOXYSPERGUALIN; ANTIGEN; AUTOANTIBODY; AZATHIOPRINE; BETA2 INTEGRIN; CYCLOPHOSPHAMIDE; FC RECEPTOR; GENISTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; LEFLUNOMIDE; LEUKOCYTE ANTIBODY; METHOTREXATE; METHYLPREDNISOLONE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PREDNISOLONE; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ANTIBODY DETECTION; ANTIBODY SPECIFICITY; AUTOIMMUNE DISEASE; BLADDER CANCER; BONE MARROW SUPPRESSION; CHURG STRAUSS SYNDROME; CLINICAL TRIAL; CYSTITIS; DIABETES MELLITUS; DISEASE ASSOCIATION; HUMAN; HYPERSENSITIVITY REACTION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY FAILURE; LEUKOCYTE; LUNG HEMORRHAGE; MOLECULAR INTERACTION; NEUTROPHIL; NONHUMAN; OSTEOPOROSIS; PATHOGENESIS; PLASMAPHERESIS; REPRODUCTIVE TOXICITY; REVIEW; SIGNAL TRANSDUCTION; SKIN CANCER; TOXICITY; VASCULITIS; WEGENER GRANULOMATOSIS;

EID: 0037345502     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(02)00094-8     Document Type: Short Survey

References (17)

1. Cockwell P., Savage C.O. Role of leukocytes in the immunopathogenesis of ANCA-associated glomerulonephritis. Nephron. 85(4):2000;287-306.
2. Harper L., Savage C.O. Leukocyte-endothelial interactions in antineutrophil cytoplasmic antibody-associated systemic vasculitis. Rheum. Dis. Clin. North Am. 27(4):2001;887-903.
3. Jennette J.C.et al. Induction of pauci-immune necrotising and crescentic glomerulonephritis (NCGN) by intravenous administration of anti-myeloperoxidase (anti-MPO) antibodies to recombinase activating gene-2 deficient (RAG-2-/-) mice. Cleveland Clin. J. Med. 69(Suppl. 2):2002;13A.
4. Witko-Sarsat V.et al. Presence of proteinase 3 in secretory vesicles: evidence of a novel, highly mobilizable intracellular pool distinct from azurophil granules. Blood. 94(7):1999;2487-2496.
5. Kettritz R.et al. Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies. J. Am. Soc. Nephrol. 12(1):2001;37-46.
6. Kurosawa S., Esmon C.T., Stearns-Kurosawa D.J. The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18. J. Immunol. 165(8):2000;4697-4703.
7. Reumaux D.et al. Effect of tumor necrosis factor-induced integrin activation on Fc gamma receptor II-mediated signal transduction: relevance for activation of neutrophils by anti-proteinase 3 or anti-myeloperoxidase antibodies. Blood. 86(8):1995;3189-3195.
8. Hess C., Sadallah S., Schifferli J.A. Induction of neutrophil responsiveness to myeloperoxidase antibodies by their exposure to supernatant of degranulated autologous neutrophils. Blood. 96(8):2000;2822-2827.
9. Radford D.J., Lord J.M., Savage C.O. The activation of the neutrophil respiratory burst by anti-neutrophil cytoplasm autoantibody (ANCA) from patients with systemic vasculitis requires tyrosine kinases and protein kinase C activation. Clin. Exp. Immunol. 118(1):1999;171-179.
10. Iking-Konert C.et al. Polymorphonuclear neutrophils in Wegener's granulomatosis acquire characteristics of antigen presenting cells. Kidney Int. 60(6):2001;2247-2262.
11. Radford D.J.et al. Antineutrophil cytoplasmic antibodies stabilize adhesion and promote migration of flowing neutrophils on endothelial cells. Arthritis Rheum. 44(12):2001;2851-2861.
12. Hewins P., Wakelam M., Savage C. The tyrosine kinase Syk is recruited by anti-neutrophil cytoplasm antibodies (ANCA) during the activation of neutrophils: potential pathogenic significance in small vessel vasculitis. J. Am. Soc. Nephrol. 12:2001;652A. (Program and Abstracts ASN/ISN World Congress of Nephrology).
13. Ben-Smith A.et al. Antineutrophil cytoplasm autoantibodies from patients with systemic vasculitis activate neutrophils through distinct signaling cascades: comparison with conventional Fcgamma receptor ligation. Blood. 98(5):2001;1448-1455.
14. Hattar K.et al. Subthreshold concentrations of anti-proteinase 3 antibodies (c-ANCA) specifically prime human neutrophils for fMLP-induced leukotriene synthesis and chemotaxis. J. Leukocyte Biol. 69(1):2001;89-97.
15. Grimminger F.et al. Neutrophil activation by anti-proteinase 3 antibodies in Wegener's granulomatosis: role of exogenous arachidonic acid and leukotriene B4 generation. J. Exp. Med. 184(4):1996;1567-1572.
16. Jayne D. Update on the European Vasculitis Study Group trials. Curr. Opin. Rheumatol. 13(1):2001;48-55.
17. de Groot K., Adu D., Savage C.O. The value of pulse cyclophosphamide in ANCA-associated vasculitis: meta-analysis and critical review. Nephrol. Dial. Transplant. 16(10):2001;2018-2027.