-
1
-
-
0032922359
-
The role of tumour necrosis factor in health and disease
-
Beutler BA. The role of tumour necrosis factor in health and disease. J Rheumatol 1999; 26 (suppl 57):16-21.
-
(1999)
J Rheumatol
, vol.26
, Issue.SUPPL. 57
, pp. 16-21
-
-
Beutler, B.A.1
-
2
-
-
0029830209
-
Tumour necrosis factor alpha (TNF-α): The good, the bad and the potentially very effective
-
Barbara JA, Van Ostade X, Lopez A. Tumour necrosis factor alpha (TNF-α): the good, the bad and the potentially very effective. Immunol Cell Biol 1996; 75:434-443.
-
(1996)
Immunol Cell Biol
, vol.75
, pp. 434-443
-
-
Barbara, J.A.1
Van Ostade, X.2
Lopez, A.3
-
3
-
-
0026771135
-
Tumour necrosis factor (TNF-α) and lymphotoxin (TNF-β)
-
Riddle NH. Tumour necrosis factor (TNF-α) and lymphotoxin (TNF-β). Curr Opin Immunol 1992; 4:327-332.
-
(1992)
Curr Opin Immunol
, vol.4
, pp. 327-332
-
-
Riddle, N.H.1
-
4
-
-
0000264230
-
Increased mucosal TNF-α levels and numbers of TNF-α producing cells are unique to Crohn's disease mucosal inflammation
-
Plevy SE, Targan SR, Deem RL, Toyoda H. Increased mucosal TNF-α levels and numbers of TNF-α producing cells are unique to Crohn's disease mucosal inflammation. Gastroenterology 1995; 106:A754.
-
(1995)
Gastroenterology
, vol.106
-
-
Plevy, S.E.1
Targan, S.R.2
Deem, R.L.3
Toyoda, H.4
-
5
-
-
0028236232
-
Tumour necrosis factor α-producing cells in the intestinal mucosa of children with inflammatory bowel disease
-
Breese EJ, Michie CA, Nicholls SW, Murch SH, Williams CB, Domizio P, et al. Tumour necrosis factor α-producing cells in the intestinal mucosa of children with inflammatory bowel disease. Gastroenterology 1994; 106:1455-1466.
-
(1994)
Gastroenterology
, vol.106
, pp. 1455-1466
-
-
Breese, E.J.1
Michie, C.A.2
Nicholls, S.W.3
Murch, S.H.4
Williams, C.B.5
Domizio, P.6
-
6
-
-
0026531017
-
Tumour necrosis factor alpha in stool as a marker of intestinal inflammation
-
Braegger CP, Nicholls S, Murch SH, Stephens S, MacDonald TT. Tumour necrosis factor alpha in stool as a marker of intestinal inflammation. Lancet 1992; 339:89-91.
-
(1992)
Lancet
, vol.339
, pp. 89-91
-
-
Braegger, C.P.1
Nicholls, S.2
Murch, S.H.3
Stephens, S.4
MacDonald, T.T.5
-
7
-
-
0027486125
-
Location of tumour necrosis factor α by immunohistochemistry in chronic inflammatory bowel disease
-
Murch SH, Braegger CP, Walker-Smith JA, MacDonald TT. Location of tumour necrosis factor α by immunohistochemistry in chronic inflammatory bowel disease. Gut 1993; 34:1705-1709.
-
(1993)
Gut
, vol.34
, pp. 1705-1709
-
-
Murch, S.H.1
Braegger, C.P.2
Walker-Smith, J.A.3
MacDonald, T.T.4
-
8
-
-
0028038782
-
Inflammatory granuloma formation is mediated by TNF-alpha inducible intercellular adhesion molecule-1
-
Lukacs NW, Chensue SW, Strieter R, Warmington K, Kunkel SL. Inflammatory granuloma formation is mediated by TNF-alpha inducible intercellular adhesion molecule-1. J Immunol 1994; 152:5883-5889.
-
(1994)
J Immunol
, vol.152
, pp. 5883-5889
-
-
Lukacs, N.W.1
Chensue, S.W.2
Strieter, R.3
Warmington, K.4
Kunkel, S.L.5
-
9
-
-
0027361432
-
Construction and initial characterization of a mouse-human anti-TNF-antibody
-
Knight DM, Trinh H, Le J, Siegel S, Shealy D, McDonough M, et al. Construction and initial characterization of a mouse-human anti-TNF-antibody. Mol Immunol 1993; 30:1443-1453.
-
(1993)
Mol Immunol
, vol.30
, pp. 1443-1453
-
-
Knight, D.M.1
Trinh, H.2
Le, J.3
Siegel, S.4
Shealy, D.5
McDonough, M.6
-
10
-
-
0028964310
-
The mouse/human chimeric monoclonal antibody cA2 neutralizes in vitro and protects transgenic mice from cachexia and TNF-α lethality in vivo
-
Siegel SA, Shealy DJ, Nakada MT, Le J, Woulfe DS, Probert L, et al. The mouse/human chimeric monoclonal antibody cA2 neutralizes in vitro and protects transgenic mice from cachexia and TNF-α lethality in vivo. Cytokine 1995; 7:15-25.
-
(1995)
Cytokine
, vol.7
, pp. 15-25
-
-
Siegel, S.A.1
Shealy, D.J.2
Nakada, M.T.3
Le, J.4
Woulfe, D.S.5
Probert, L.6
-
11
-
-
0029004771
-
Chimeric anti-TNF-monoclonal antibody cA2 binds recombinant transmembrane TNF and activates immune effector functions
-
Scallon BJ, Moore MA, Trinh H, Knight DM, Ghrayeb J. Chimeric anti-TNF-monoclonal antibody cA2 binds recombinant transmembrane TNF and activates immune effector functions. Cytokine 1995; 7:251-259.
-
(1995)
Cytokine
, vol.7
, pp. 251-259
-
-
Scallon, B.J.1
Moore, M.A.2
Trinh, H.3
Knight, D.M.4
Ghrayeb, J.5
-
12
-
-
0036151047
-
Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease
-
Ten Hove T, van Montfrans C, Peppelenbosch MP, van Deventer SJH. Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease. Gut 2002; 50:206-211. Important work illustrating the mechanism of action of infliximab and explaining why it might be superior to other anti-TNF antibodies.
-
(2002)
Gut
, vol.50
, pp. 206-211
-
-
Ten Hove, T.1
Van Montfrans, C.2
Peppelenbosch, M.P.3
Van Deventer, S.J.H.4
-
13
-
-
0030954732
-
A short-term study of chimeric monoclonal antibody cA2 to tumour necrosis factor alpha for Crohn's disease
-
Crohn's Disease cA2 Study Group
-
Targan SR, Hanauer SB, van Deventer SJ, Mayer L, Present DH, Braakman T, et al. A short-term study of chimeric monoclonal antibody cA2 to tumour necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med 1997; 337:1029-1035. Pivotal trial demonstrating the potent efficacy of infliximab in active Crohn's disease.
-
(1997)
N Engl J Med
, vol.337
, pp. 1029-1035
-
-
Targan, S.R.1
Hanauer, S.B.2
Van Deventer, S.J.3
Mayer, L.4
Present, D.H.5
Braakman, T.6
-
14
-
-
0000493124
-
A multicenter trial of cA2 anti-TNF chimeric monoclonal antibody in patients with active Crohn's disease
-
McCabe RP, Woody J, van Deventer SJH, Targan SR, Mayer L, van Hogezand R, et al. A multicenter trial of cA2 anti-TNF chimeric monoclonal antibody in patients with active Crohn's disease. Gastroenterology 1996; 110:A962.
-
(1996)
Gastroenterology
, vol.110
-
-
McCabe, R.P.1
Woody, J.2
Van Deventer, S.J.H.3
Targan, S.R.4
Mayer, L.5
Van Hogezand, R.6
-
15
-
-
0032913394
-
Endoscopic and histological healing with infliximab antibodies in Crohn's disease: A European multicenter trial
-
D'Haens G, van Deventer S, Van Hogezand R, Chalmers D, Kothe C, Baert F, et al. Endoscopic and histological healing with infliximab antibodies in Crohn's disease: a European multicenter trial. Gastroenterology 1999; 116:1029-1034. This trial shows consistent endoscopic healing with infliximab in parallel with clinical improvement and accompanied by disappearance of inflammatory cells from the inflamed mucosa.
-
(1999)
Gastroenterology
, vol.116
, pp. 1029-1034
-
-
D'Haens, G.1
Van Deventer, S.2
Van Hogezand, R.3
Chalmers, D.4
Kothe, C.5
Baert, F.6
-
16
-
-
0032923705
-
Tumour necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis
-
Baert FJ, D'Haens GR, Peeters M, Hiele MI, Schaible TF, Shealy D, et al. Tumour necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis. Gastroenterology 1999; 116:22-28.
-
(1999)
Gastroenterology
, vol.116
, pp. 22-28
-
-
Baert, F.J.1
D'Haens, G.R.2
Peeters, M.3
Hiele, M.I.4
Schaible, T.F.5
Shealy, D.6
-
17
-
-
0035068351
-
Infliximab for Crohn's disease in clinical practice at the Mayo clinic: The first 100 patients
-
Ricart E, Panaccione R, Loftus EV, Tremaine WJ, Sandborn WJ. Infliximab for Crohn's disease in clinical practice at the Mayo clinic: the first 100 patients. Am J Gastroenterol 2001; 96;722-729.
-
(2001)
Am J Gastroenterol
, vol.96
, pp. 722-729
-
-
Ricart, E.1
Panaccione, R.2
Loftus, E.V.3
Tremaine, W.J.4
Sandborn, W.J.5
-
18
-
-
0033761188
-
Prolonged duration of response to infliximab in early but not late pediatric Crohn's disease
-
Kugathasan S, Werlin SL, Martinez A, Rivera MT, Heikenen JB, Binion DG. Prolonged duration of response to infliximab in early but not late pediatric Crohn's disease. Am J Gastroenterol 2000; 95:3089-3194.
-
(2000)
Am J Gastroenterol
, vol.95
, pp. 3089-3194
-
-
Kugathasan, S.1
Werlin, S.L.2
Martinez, A.3
Rivera, M.T.4
Heikenen, J.B.5
Binion, D.G.6
-
19
-
-
0032833517
-
Efficacy and safety of retreatment with anti-tumour necrosis factor antibody (infliximab) to maintain remission in Crohn's disease
-
Rutgeerts P, D'Haens G, Targan S, van Deventer SH, Present DH, Mayer L. Efficacy and safety of retreatment with anti-tumour necrosis factor antibody (infliximab) to maintain remission in Crohn's disease. Gastroenterology 1999; 117:761-769. This trial not only showed that repeated infusions of infliximab continue to be effective and, more importantly, that the incidence of adverse events did not increase with repeated use.
-
(1999)
Gastroenterology
, vol.117
, pp. 761-769
-
-
Rutgeerts, P.1
D'Haens, G.2
Targan, S.3
Van Deventer, S.H.4
Present, D.H.5
Mayer, L.6
-
20
-
-
0037018761
-
Maintenance infliximab for Crohn's disease: The Accent I randomised trial
-
Hanauer SB, Feagan BG, Lichtenstein GR, Mayer LF, Schreiber S, Colombel JF, et al. Maintenance infliximab for Crohn's disease: the Accent I randomised trial. Lancet 2002; 359:1541-1549. This trial is, so far, the largest controlled trial in Crohn's disease. Due to its meticulous but complex design, many questions were addressed at the same time. Results show that both systematic and 'on demand' retreatment with infliximab are safe and effective.
-
(2002)
Lancet
, vol.359
, pp. 1541-1549
-
-
Hanauer, S.B.1
Feagan, B.G.2
Lichtenstein, G.R.3
Mayer, L.F.4
Schreiber, S.5
Colombel, J.F.6
-
21
-
-
0003037738
-
Endoscopic healing after infliximab treatment for Crohn's disease provides a longer time to relapse
-
D'Haens GR, Noman M, Baert F, Hiele M, Van Assche G, Daperno M, et al. Endoscopic healing after infliximab treatment for Crohn's disease provides a longer time to relapse [Abstract]. Gastroenterology 2002; 122:A100.
-
(2002)
Gastroenterology
, vol.122
-
-
D'Haens, G.R.1
Noman, M.2
Baert, F.3
Hiele, M.4
Van Assche, G.5
Daperno, M.6
-
22
-
-
0033529049
-
Infliximab for the treatment of fistulas in patients with Crohn's disease
-
Present DH,. Rutgeerts P, Targan S, Hanauer SB, Mayer L, van Hogezand RA, et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 1999; 340:1398-1405. Largest ever trial in fistulizing Crohn's disease. Although the efficacy was better than has ever been shown with other therapies, the duration of response was disappointingly short, in spite of an induction regimen of three infusions.
-
(1999)
N Engl J Med
, vol.340
, pp. 1398-1405
-
-
Present, D.H.1
Rutgeerts, P.2
Targan, S.3
Hanauer, S.B.4
Mayer, L.5
Van Hogezand, R.A.6
-
23
-
-
0001965508
-
Long-term treatment of fistulizing Crohn's disease: Response to infliximab in the Accent II trial through 54 weeks
-
Sands B, Van Deventer S, Bernstein C, Kamm M, Rachmilewitz D, Chey W, et al. Long-term treatment of fistulizing Crohn's disease: response to infliximab in the Accent II trial through 54 weeks [Abstract]. Gastroenterology 2002; 122:A81.
-
(2002)
Gastroenterology
, vol.122
-
-
Sands, B.1
Van Deventer, S.2
Bernstein, C.3
Kamm, M.4
Rachmilewitz, D.5
Chey, W.6
-
24
-
-
0036144887
-
Endosonographic evidence of persistence of Crohn's disease-associated fistulas after infliximab treatment, irrespective of clinical response
-
van Bodegraven AA, Sloots CE, Felt-Bersma RJ, Meuwissen SG. Endosonographic evidence of persistence of Crohn's disease-associated fistulas after infliximab treatment, irrespective of clinical response. Dis Colon Rectum 2002; 45:39-45.
-
(2002)
Dis Colon Rectum
, vol.45
, pp. 39-45
-
-
Van Bodegraven, A.A.1
Sloots, C.E.2
Felt-Bersma, R.J.3
Meuwissen, S.G.4
-
25
-
-
17744373658
-
Infliximab induces potent antiinflammatory and local immunomodulatory activity but no systemic immune suppression in patients with Crohn's disease
-
Cornillie F, Shealy D, D'Haens G, Geboes K, Van Assche G, Ceuppens J, et al. Infliximab induces potent antiinflammatory and local immunomodulatory activity but no systemic immune suppression in patients with Crohn's disease. Ailment Pharmacol Ther 2001; 15:463-473.
-
(2001)
Ailment Pharmacol Ther
, vol.15
, pp. 463-473
-
-
Cornillie, F.1
Shealy, D.2
D'Haens, G.3
Geboes, K.4
Van Assche, G.5
Ceuppens, J.6
-
26
-
-
4244131796
-
Post infusion infliximab levels determine duration of response in Crohn's disease and are directly related to infusion reactions
-
Noman M, Baert F, Vermeire S, Van Assche G, D'Haens G, Carbonez A, et al. Post infusion infliximab levels determine duration of response in Crohn's disease and are directly related to infusion reactions [Abstract]. Gastroenterology 2002; 122:A100.
-
(2002)
Gastroenterology
, vol.122
-
-
Noman, M.1
Baert, F.2
Vermeire, S.3
Van Assche, G.4
D'Haens, G.5
Carbonez, A.6
-
27
-
-
0000777268
-
A randomized, double-blind, placebo-controlled trial of intravenous hydrocortisone in reducing human anti-chimeric antibody following infliximab therapy
-
Alsahli M, Jeen YT, Peppercorn M, Michetti P, Farrell RJ. A randomized, double-blind, placebo-controlled trial of intravenous hydrocortisone in reducing human anti-chimeric antibody following infliximab therapy [Abstract]. Gastroenterology 2002; 122:A100.
-
(2002)
Gastroenterology
, vol.122
-
-
Alsahli, M.1
Jeen, Y.T.2
Peppercorn, M.3
Michetti, P.4
Farrell, R.J.5
-
28
-
-
0000200979
-
Delayed hypersensitivity to infliximab (Remicade) infusion after a 2-4 year interval without treatment
-
Hanauer SB, Rutgeerts PJ, D'Haens GR, Targan SR, Kam L, Present DH, et al. Delayed hypersensitivity to infliximab (Remicade) infusion after a 2-4 year interval without treatment [Abstract]. Gastroenterology 1999; 116:G3174.
-
(1999)
Gastroenterology
, vol.116
-
-
Hanauer, S.B.1
Rutgeerts, P.J.2
D'Haens, G.R.3
Targan, S.R.4
Kam, L.5
Present, D.H.6
-
29
-
-
0035846326
-
Tuberculosis associated with infliximab, a tumour necrosis factor alpha-neutralizing agent
-
Keane J, Gershon S, Wise RP, Mirabile-Levens E. Tuberculosis associated with infliximab, a tumour necrosis factor alpha-neutralizing agent. N Engl J Med 2001; 345:1098-1104.
-
(2001)
N Engl J Med
, vol.345
, pp. 1098-1104
-
-
Keane, J.1
Gershon, S.2
Wise, R.P.3
Mirabile-Levens, E.4
-
30
-
-
0003099326
-
High incidence of anergy limits the usefulness of PPD screening for tuberculosis prior to Remicade in inflammatory bowel disease
-
Mow WS, Abreu MT, Papadakis KA, Targan SR, Vasiliauskas EA. High incidence of anergy limits the usefulness of PPD screening for tuberculosis prior to Remicade in inflammatory bowel disease [Abstract]. Gastroenterology 2002; 122:A100.
-
(2002)
Gastroenterology
, vol.122
-
-
Mow, W.S.1
Abreu, M.T.2
Papadakis, K.A.3
Targan, S.R.4
Vasiliauskas, E.A.5
-
31
-
-
0000487030
-
Complete bowel obstruction following initial response to infliximab therapy: A series of a newly described complication
-
Toy LS, Abittan C, Kornbluth A, Scherl EJ, Greenstein AJ, Agus S, et al. Complete bowel obstruction following initial response to infliximab therapy: a series of a newly described complication. Gastroenterology 2000; 118:A569.
-
(2000)
Gastroenterology
, vol.118
-
-
Toy, L.S.1
Abittan, C.2
Kornbluth, A.3
Scherl, E.J.4
Greenstein, A.J.5
Agus, S.6
|