Identification and characterization of the new gene rhtA involved in threonine and homoserine efflux in Escherichia coli

Research in Microbiology

Volumn 154, Issue 2, 2003, Pages 123-135

  Livshits, Vitaliy A ^a   Zakataeva, Natalia P ^a   Aleshin, Vladimir V ^b,c   Vitushkina, Maria V ^a  

^a Ajinomoto Genetika Research Institute   (Russian Federation)

^b STATE RESEARCH INSTITUTE OF GENETICS AND SELECTION OF INDUSTRIAL MICROORGANISMS   (Russian Federation)

^c MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Efflux; Homoserine; Membrane protein; Threonine; Transport

Indexed keywords

AMINO ACID; HOMOSERINE; LYSINE; MEMBRANE PROTEIN; PROLINE; PROTEIN; PROTEIN RHTA; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GENOME; CODON; CONTROLLED STUDY; ESCHERICHIA COLI; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; GENETIC CODE; GENETIC TRAIT; HYDROPHOBICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PARALOGY; PHYLOGENY; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

ESCHERICHIA COLI;

EID: 0037341767     PISSN: 09232508     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-2508(03)00036-6     Document Type: Article

References (51)

1. Adachi J., Hasegawa M. Instability of quartet analyses of molecular sequence data by the maximum likelihood method: the Cetacea/Artiodactyla relationships. Mol. Phylogenet. Evol. 6:1996;72-76.
2. Aleshin V.V., Zakataeva N.P., Livshits V.A. A new family of amino acid efflux proteins. Trends Biochem. Sci. 24:1999;133-135.
3. Altschul S.F., Madden T.L., Schäffer A.A., Zhang J., Zhang Z., Miller W., Lipman D.J. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res. 25:1997;3389-3402.
4. Bateman A., Birney E., Durbin R., Eddy S.R., Howe K.L., Sonnhammer E.L.L. The Pfam protein family database. Nucleic Acids Res. 28:2000;263-266.
5. Bellmann A., Vrljić M., Pátek M., Sahm H., Krämer R., Eggeling L. Expression control and specificity of the basic amino acid exporter LysE of Corynebacterium glutamicum. Microbiology. 147:2001;1765-1774.
6. Daßler T., Maier T., Winterhalter C., Böck A. Identification of a major facilitator protein from Escherichia coli involved in efflux of metabolites of the cysteine pathway. Mol. Microbiol. 36:2000;1101-1112.
7. V.G. Debabov, J.I. Kozlov, E.M. Khurges, V.A. Livshits, N.I. Zhdanova, M.M. Gusyatiner, A.K. Sokolov, T.A. Bachina, Bacterial strain of Escherichia coli VNII GENETIKA 472T23 as the producer of L-threonine, United States patent 5,631,157, Ajinomoto, Tokio, Japan, 1997.
8. Ebbighausen H., Weil B., Krämer R. Isoleucine excretion in Corynebacterium glutamicum: Evidence for a specific efflux carrier system. Appl. Microbiol. Biotechnol. 31:1989;184-190.
9. J. Felsenstein, PHYLIP - Phylogeny Inference Package, version 3.5, University of Washington, Seattle, 1993.
10. Grass G., Groβe C., Nies D.H. Regulation of the cnr cobalt and nickel resistance determinant from Ralstonia sp. Strain CH34. J. Bacteriol. 182:2000;1390-1398.
11. Groisman E.A., Casadaban M.J. Mini-Mu bacteriophage with plasmid replicons for in vivo cloning and lac gene fusing. J. Bacteriol. 168:1986;357-364.
12. Gusyatiner M.M., Zhdanova N.I., Livshits V.A., Zaigraeva G.G., Shakulov R.S. Investigation of the relA gene function in the expression of amino acid operons. II. Effect of the relA gene allelic state on the overproduction of threonine by an Escherichia coli K-12 mutant resistant to β -hydroxynorvaline. Genetika. 14:1978;957-968. (in Russian).
13. Hama H., Kayahara T., Tsuda M., Tsuchiya T. Inhibition of homoserine dehydrogenase I by L-serine in Escherichia coli. J. Biochem. (Tokyo). 109:1991;604-608.
14. Harris C.L. Cysteine and growth inhibition of Escherichia coli: Threonine deaminase as the target enzyme. J. Bacteriol. 145:1981;1031-1035.
15. Hirose Y., Okada H. Microbial production of amino acids. Peppler H.J., Perlman D. Microbial Technology, Vol. 1. 1979;211-244 Academic Press, New York.
16. Hui A., Hayflick J., Dinkelspiel K., de Boer H.A. Mutagenesis of the three bases preceding the start codon of the β -galactosidase mRNA and its effect on translation in Escherichia coli. EMBO J. 3:1984;623-629.
17. Jack D.L., Yang N.M., Saier M.H. Jr. The drug/metabolite transporter superfamily. Eur. J. Biochem. 268:2001;3620-3639.
18. Kotre A.M., Sullivan S.J., Savageau M.A. Metabolic regulation by homoserine in Escherichia coli B/r. J. Bacteriol. 116:1973;663-672.
19. Krämer R. Systems and mechanisms of amino acid uptake and excretion in prokaryotes. Arch. Microbiol. 162:1994;1-13.
20. Kyte J., Doolittle R.F. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157:1982;105-132.
21. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
22. V.A. Livshits, N.P. Zakataeva, K. Nakanishi, V.V. Aleshin, P.V. Troshin, I.L. Tokmakova, Escherichia coli DNA fragment determining enhanced production of amino acids (variants) and method of amino acid producing, Russian patent No. 2175351, GNII Genetika, Moscow, Russia, 2001.
23. Lolkema J.S., Slotboom D.-J. Hydropathy profile aligment: A tool to search for structural homologues of membrane proteins. FEMS Microbiol. Rev. 22:1998;305-322.
24. 38 -dependent expression of a core Escherichia coli starvation gene, pexB. J. Bacteriol. 176:1994;3928-3935.
25. Makrides S.C. Strategies for achiving high-level expression of genes in Escherichia coli. Microbiol. Rev. 60:1996;512-538.
26. Miller J.H. Experiments in Molecular Genetics. 1972;Cold Spring Harbor Laboratory Press, New York.
27. Nikaido H. Multidrug efflux pumps of gram-negative bacteria. J. Bacteriol. 178:1996;5853-5859.
28. Nochno T., Saito T., Hong J.-S. Cloning and complete nucleotide sequence of the Escherichia coli glutamine permease operon (glnHPQ). Mol. Gen. Genet. 205:1986;260-269.
29. Okamoto K., Kino K., Ikeda M. Hyperproduction of L-threonine by Escherichia coli mutant with impaired L-threonine uptake. Biosci. Biotech. Biochem. 61:1997;1877-1882.
30. Page R.D.M. TREEVIEW: An application to display phylogenetic trees on personal computers. Comp. Appl. Biosci. 12:1996;357-358.
31. Parker B., Marinus M.G. A simple and rapid method to obtain substitution mutations in Escherichia coli: Isolation of a dam deletion/insertion mutation. Gene. 73:1988;531-535.
32. Payne J.W., Smith M.W. Peptide transport by microorganisms. Adv. Microb. Physiol. 36:1994;1-80.
33. Praillet T., Reverchon S., Robert-Baudouy J., Nasser W. The PecM protein is necessary for the DNA-binding capacity of the PecS repressor, one of the regulators of virulence-factor synthesis in Erwinia chrysanthemi. FEMS Microbiol. Lett. 154:1997;265-270.
34. Rouanet C., Nasser W. The PecM protein of the phytopathogenic bacterium Erwinia chrysanthemi, membrane topology and possible involvement in the efflux of the blue pigment indigoidine. J. Mol. Microbiol. Biotechnol. 3:2001;309-318.
35. Saier M.H. Jr., Paulsen I.T., Sliwinski M.K., Pao S.S., Skurrey R.A., Nikaido H. Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria. FASEB J. 12:1998;265-274.
36. Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning, A Laboratory Manual. 1989;Cold Spring Harbor Laboratory Press, New York.
37. Santiviago C.A., Fuentes J.A., Bueno S.M., Trombert A.N., Hildago A.A., Socias L.T., Youderian P., Mora G.C. The Salmonella enterica sv. Typhimurium smvA, yddG, and ompD (porin) genes are required for the efficient efflux of methyl viologen. Mol. Microbiol. 46:2002;687-698.
38. Simic P., Sahm H., Eggeling L. L-Threonine export: Use of peptides to identify a new translocator from Corynebacterium glutamicum. J. Bacteriol. 183:2001;5317-5324.
39. Strimmer K., von Haeseler A. Quartet puzzling: A quartet maximum likelihood method for reconstructing tree topologies. Mol. Biol. Evol. 24:1996;964-969.
40. Tabor S., Richardson C.C. A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. Proc. Natl. Acad. Sci. USA. 82:1985;1074-1078.
41. Tatusov R.L., Natale D.N., Garkavtsev I.V., Tatusova T.A., Shankavaram U.T., Rao B.S., Kiryutin B., Galperin M.Y., Fedorova N.D., Koonin E.V. The COG database: New developments in phylogenetic classification of proteins from complete genomes. Nucleic Acids Res. 28:2001;263-266.
42. Theze J., Saint-Girons I. Threonine locus of Escherichia coli K-12: Genetic structure and evidence for an operon. J. Bacteriol. 118:1974;990-998.
43. Thompson J.D., Higgins D.G., Gibson T.J. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:1994;4673-4680.
44. Tusnády G.E., Simon I. Principles governing amino acid composition of integral membrane proteins: Application to topology prediction. J. Mol. Biol. 283:1998;489-506.
45. Umbarger H.E. Biosynthesis of the branched-chain amino acids. Neidhardt F.C., Curtiss R. III, Ingraham J.L., Lin E.C.C., Low K.B., Magasanik B., Reznikoff W.S., Riley M., Schaecher M., Umbarger H.E. Escherichia coli and Salmonella typhymurium: Cellular and Molecular Biology, Vol. 1. 1996;442-457 American Society for Microbiology Press, Washington.
46. Umbarger H.E. Metabolic analogues as genetic and biochemical probes. Adv. Genet. 16:1971;119-140.
47. Vieira J., Messing J. New pUC-derived cloning vectors with different selectable markers and DNA replication origins. Gene. 100:1991;189-194.
48. Vrljic M., Sahm H., Eggeling L. A new type of transporter with a new type of cellular function: L-lysine export from Corynebacterium glutamicum. Mol. Microbiol. 22:1996;815-826.
49. Wallace B., Yang Y.-J., Hong J., Lum D. Cloning and sequencing of a gene encoding a glutamate and aspartate carrier of Escherichia coli K-12. J. Bacteriol. 172:1990;3214-3220.
50. Yen M.-R., Tseng Y.-H., Simic P., Sahm H., Eggeling L., Saier M.H. Jr. The ubiquitous ThrE family of putative transmembrane amino acid efflux transporters. Res. Microbiol. 153:2002;19-25.
51. Zakataeva N.P., Aleshin V.V., Tokmakova I.L., Troshin P.V., Livshits V.A. The novel transmembrane Escherichia coli proteins involved in the amino acid efflux. FEBS Lett. 452:1999;228-232.