Psychotic symptoms in severe MTHFR deficiency and their successful treatment with betaine

European Journal of Pediatrics

Volumn 162, Issue 3, 2003, Pages 200-201

  Bönig, Halvard ^a   Däublin, Gerhard ^a   Schwahn, Bernd ^a   Wendel, Udo ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BETAINE; HOMOCYSTEINE; METHIONINE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

AMINO ACID BLOOD LEVEL; ARTICLE; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; CHILD; CLINICAL EXAMINATION; DISEASE COURSE; DRUG EFFICACY; ENZYME DEFICIENCY; FIBROBLAST CULTURE; HUMAN; HYPERHOMOCYSTEINEMIA; MALE; PRIORITY JOURNAL; PSYCHOSIS;

EID: 0037340211     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00431-002-1148-9     Document Type: Article

References (6)

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2. Bottiglieri T, Hyland K (1994) S-adenosylmethionine levels in psychiatric and neurological disorders: a review. Acta Neurol Scand Suppl 154:19-26
3. Freeman JM, Finkelstein JD, Mudd SH (1975) Folate-responsive homocystinuria and "schizophrenia". A defect in methylation due to deficient 5,10-methylenetetrahydrofolate reductase activity. N Engl J Med 292:491-496
4. Pasquier F, Lebert F, Petit H (1994) Methylenetetrahydrofolate reductase deficiency revealed by a neuropathy in a psychotic adult. J Neurol Neurosurg Psychiatry 57:765-766
5. Regland B, Johannson BV, Gottfries CG (1994) Homocysteinemia and schizophrenia as a case of methylation deficiency. J Neural Transm 98:143-152
6. Surtees R, Bowron A, Leonard J (1997) Cerebrospinal fluid and plasma total homocysteine and related metabolites in children with cystathionine beta-synthase deficiency: the effect of treatment. Pediatr Res 42:577-582