Injection pain of rocuronium and vecuronium is evoked by direct activation of nociceptive nerve endings

European Journal of Anaesthesiology

Volumn 20, Issue 3, 2003, Pages 245-253

  Blunk, J A ^a   Seifert, F ^a   Schmelz, M ^a   Reeh, P W ^a   Koppert, W ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Neuromuscular blocking agents, vecuronium bromide, rocuronium bromide; Peripheral nervous system, nociceptors; Psychophysiology, pain

Indexed keywords

BRADYKININ; HISTAMINE; NEUROMUSCULAR BLOCKING AGENT; PROTEIN; ROCURONIUM; TRYPTASE; VECURONIUM;

ADULT; ARTICLE; BURNING SENSATION; CONTROLLED STUDY; EVOKED RESPONSE; HUMAN; HUMAN EXPERIMENT; INJECTION PAIN; MEDIATOR RELEASE; MICRODIALYSIS; NERVE ENDING; NERVE EXCITABILITY; NERVE FIBER; NOCICEPTION; NORMAL HUMAN; PAIN ASSESSMENT; RECEPTIVE FIELD; SKIN NERVE; WITHDRAWAL SYNDROME;

ADULT; ANDROSTANOLS; ANIMALS; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; FEMALE; FOREARM; HUMANS; LASER-DOPPLER FLOWMETRY; MALE; MICE; MICRODIALYSIS; NERVE ENDINGS; NERVE FIBERS; NEURAL CONDUCTION; NEUROMUSCULAR NONDEPOLARIZING AGENTS; NOCICEPTORS; PAIN; REGIONAL BLOOD FLOW; VECURONIUM BROMIDE;

EID: 0037334979     PISSN: 02650215     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0265021503000413     Document Type: Article

References (30)

1. Lockey D, Coleman P. Pain during injection of rocuronium bromide. Anaesthesia 1995; 50: 474.
2. Moorthy SS, Dierdorf SF. Pain on injection of rocuronium bromide. Anesth Analg 1995; 80: 1067.
3. Robertson EN. Pain on administration of vecuronium. Anaesthesia 1996; 51: 93.
4. Steeger MAH, Robertson EN. Pain on injection of rocuronium bromide. Anesth Analg 1996; 83: 203.
5. Joshi GP, Whitten CW. Pain on injection of rocuronium bromide. Anesth Analg 1997; 84: 228.
6. Borgeat A, Kwiatkowski D. Spontaneous movements associated with rocuronium: is pain on injection the cause? Br J Anaesth 1997; 79: 382-383.
7. Shevchenko Y, Jocson JC, McRae VA, et al. The use of lidocaine for preventing the withdrawal associated with the injection of rocuronium in children and adolescents. Anesth Analg 1999; 88: 746-748.
8. Robertson EN, Hull JM, Verbeek AM, Booij LHDJ. A comparison of rocuronium and vecuronium: the pharmacodynamic, cardiovascular and intra-ocular effects. Eur J Anaesthesiol 1994; 11: 116-121.
9. Kent AP, Bricker SRW, Coleman P. Pain during injection of vecuronium. Anaesthesia 1988; 43: 334.
10. Chow LH, Ho CM, Yang YC, Lee TY, Lui PW. Vecuronium dissolved in normal saline exaggerates pain on intravenous injection. Chung-Hua-I-Hsueh-Tsa-Chih-Taipei 1995; 55: 315-318.
11. Schmelz M, Luz O, Averbeck B, Bickel A. Plasma extravasation and neuropeptide in human skin as measured by intradermal microdialysis. Neurosci Lett 1997; 230: 1-4.
12. Lischetzki G, Rukwied R, Handwerker HO, Schmelz M. Nociceptor activation and protein extravasation induced by inflammatory mediators in human skin. Eur J Pain 2001; 5: 49-57.
13. Koltzenburg M, Handwerker HO. Differential ability of human cutaneous nociceptors to signal mechanical pain and to produce vasodilatation. J Neurosci 1994; 14: 1756-1765.
14. Petersen LJ, Poulsen LK, Sondergaard J, Skov PS. The use of cutaneous microdialysis to measure substance P-induced histamine release in intact human skin in vivo. J Allergy Clin Immunol 1994; 94: 773-783.
15. Reeh PW. Sensory receptors in mammalian skin in an in vitro preparation. Neurosci Lett 1986; 66: 141-146.
16. Bretag A. Synthetic interstitial fluid for isolated mammalian tissue. Life Sci 1969; 8: 319-329.
17. Forster C, Handwerker HO. Automatic classification and analysis of microneurographic spike data using a PC/AT. J Neurosci Methods 1990; 31: 109-118.
18. Cheong KF, Wong WH. Pain on injection of rocuronium: influence of two doses of lidocaine pre-treatment. Br J Anaesth 2000; 84: 106-107.
19. Arndt JO, Klement W. Pain evoked by polymodal stimulation of hand veins in humans. J Physiol 1991; 440: 467-478.
20. Klement W, Arndt JO. Pain on i.v. injection of some anaesthetic agents is evoked by the unphysiological osmolality or pH of their formulations. Br J Anaesth 1991; 66: 189-195.
21. Kindgen-Milles D, Klement W, Arndt JO. The nociceptive systems of skin, paravascular tissue and hand veins of humans and their sensitivity to bradykinin. Neurosci Lett 1994; 181: 39-42.
22. Schmelz M, Zeck S, Raithel M, Rukwied R. Mast cell tryptase in dermal neurogenic inflammation. Clin Exp Allergy 1999; 29: 652-659.
23. Steen KH, Reeh PW, Anton F, Handwerker HO. Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro. J Neurosci 1992; 12: 86-95.
24. Koppert W, Blunk JA, Petersen LJ, Skov P, Rentsch K, Schmelz M. Different patterns of mast cell activation by muscle relaxants in human skin. Anesthesiology 2001; 95: 659-667.
25. Rukwied R, Lischetzki G, McGlone F, Heyer G, Schmelz M. Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study. Br J Dermatol 2000; 142: 1114-1120.
26. Kress M, Reeh PW. Chemical excitation and sensitization in nociceptors. In: Belmonte C, Cervero F, eds. Neurobiology of Nociceptors. Oxford, UK: University Press, 1996: 258-297.
27. Petersen LJ, Poulsen LK, Sondergaard J, Skov PS. The use of cutaneous microdialysis to measure substance P-induced histamine release in intact human skin in vivo. J Allergy Clin Immunol 1994; 94: 773783.
28. Kress M, Guthmann C, Averbeck B, Reeh PW. Calcitoningene related peptide and prostaglandin E2 but not Substance P release induced by antidromic nerve stimulation from tat skin, in vitro. Neuroscience 1999; 89: 303-310.
29. Bernardini N, Sauer SK, Haberberger R, Fischer MJ, Reeh PW. Excitatory nicotinic and desensitizing muscarinic (M2) effects on C-nociceptors in isolated rat skin. J Neurosci 2001; 21: 3295-3202.
30. Liang YF, Haake B, Reeh PW. Sustained sensitisation and recruitment of rat cutaneous nociceptors by bradykinin and a novel theory of its excitatory action. J Physiol 2001; 532: 229-239.