Possible involvement of peripheral serotonin 5-HT3 receptors in fluvoxamine-induced emesis in Suncus murinus

Journal of Pharmacy and Pharmacology

Volumn 55, Issue 2, 2003, Pages 271-274

  Fujiwara Sawada, Mina ^a   Imanishi, Taiichiro ^a   Yoshida, Akiko ^a   Baba, Jun ^a  

^a MEIJI SEIKA KAISHA LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOXETINE; FLUVOXAMINE; GRANISETRON; SEROTONIN; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; SEROTONIN UPTAKE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE CALCULATION; DRUG ACTIVITY; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG MEGADOSE; DRUG RECEPTOR BINDING; DRUG TOLERABILITY; FEMALE; INSECTIVORE; LOW DRUG DOSE; MALE; NONHUMAN; RECEPTOR UPREGULATION; SUNCUS MURINUS; VOMITING;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLUOXETINE; FLUVOXAMINE; MALE; SEROTONIN UPTAKE INHIBITORS; SHREWS; VOMITING;

EID: 0037332010     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/002235702496     Document Type: Article

References (17)

1. 3 receptor antagonist and antiemetic properties. Eur. J. Pharmacol. 232: 139-145
2. 3 antagonist ondansetron reduces gastrointestinal side effects induced by a specific serotonin re-uptake inhibitor in man. J. Psychopharmacol. 9: 137-141
3. Bel, N., Artigas, F. (1992) Fluvoxamine preferentially increases extracellular 5-hydroxytryptamine in the raphe nuclei: An in vivo microdialysis study. Eur. J. Pharmacol. 229: 101-103
4. Bergeron, R., Blier, P. (1994) Cisapride for the treatment of nausea produced by selective serotonin reuptake inhibitors. Am. J. Psychiatry 151: 1084-1086
5. Endo, T., Minami, M., Hirafuji, M., Ogawa, T., Akita, K., Nemoto, M., Saito, H., Yoshioka, M., Parvez, S. H. (2000) Neurochemistry and neuropharmacology of emesis - The role of serotonin. Toxicology 153: 189-201
6. Fujiwara, M., Yamashita, N., Hayashi, A., Imanishi, T., Ichimaru, Y., Baba, J. (2000) Emetic reaaction induced by a selective serotonin reuptake inhibitor, fluvoxamine, in Suncus murinus (Abstr in English). Oyo Yakuri 59: 39-46
7. Heimke, C., Hartter, S. (2000) Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacol. Ther. 85: 11-28
8. Matsuki, N., Torii, Y., Ueno, S., Saito, H. (1992) Suncus murinus as an experimental animal model for emesis and motion sickness. In: Bianchi, A. L., Grelot, L., Miller, A. D., King, G. L. (eds) Mechanisms and Control of Emesis. John Libbey Eurotext Ltd, Montrouge, France, pp 323-329
9. McManis, P. G., Talley, N. (1997) Nausea and vomiting associated with selective serotonin reuptake inhibitors; Incidence, mechanisms and management. CNS Drugs 8: 394-401
10. Nutt, D. J., Forshall, S., Bell, C., Rich, A., Sandford, J., Nash, J., Argyropoulos, S. (1999) Mechanisms of action of selective serotonin reuptake inhibitors in the treatment of psychiatric disorders. Eur. Neuropsychopharmacol. 9: S81-86
11. 2 receptor agonist in Suncus murinus. Br. J. Pharmacol. 114: 931-934
12. Ortiz, J., Artigas, F. (1992) Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: Different effects of clomipramine and fluoxetine. Br. J. Pharmacol. 105: 941-946
13. Robbe, H. W., O'Hanlon, J. F. (1995) Acute and subchronic effects of paroxetine 20 and 40 mg on actual driving, psychomotor performance and subjective assessments in healthy volunteers. Eur. Neuropsychopharmacol. 5: 35-42
14. 3 receptor antagonists: Differences and similarities. Eur. J. Cancer 33: 1364-1370
15. Selve, N., Friderichs, E., Reimann, W., Reinartz, S. (1994) Absence of emetic effects of morphine and loperamide in Suncus murinus. Eur. J. Pharmacol. 256: 287-293
16. Torii, Y., Saito, H., Matsuki, N. (1991) 5-Hydroxytryptamine is emetogenic in the house musk shrew, Suncus murinus. Naunyn Schmiedebergs Arch. Pharmacol. 344: 564-567
17. Ueno, S., Matsuki, N., Saito, H. (1987) Suncus murinus: A new experimental model in emesis research. Life Sci. 41: 513-518