Synthesis and biological evaluation of novel 1β-methylcarbapenems with isothiazoloethenyl side chains

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 3, 2003, Pages 463-466

  Kang, Yong Koo ^a   Lee, Kyung Seok ^a   Yoo, Kyung Ho ^a   Shin, Kye Jung ^a   Kim, Dong Chan ^a   Lee, Chang Seok ^b   Kong, Jae Yang ^c   Kim, Dong Jin ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b LG Chemical Ltd   (South Korea)

^c Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

1BETA METHYLCARBAPENEM DERIVATIVE; IMIPENEM; ISOTHIAZOLE DERIVATIVE; MEROPENEM;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG SCREENING; DRUG SYNTHESIS;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; CARBAPENEMS; HALF-LIFE; INDICATORS AND REAGENTS; MICE; MICROBIAL SENSITIVITY TESTS; OXIDATION-REDUCTION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIENAMYCINS;

EID: 0037328479     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00948-4     Document Type: Article

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14. MIC (μg/mL) data. S. pyogens 308A: 0.04 (1a), 0.007 (IPM), 0.013 (MPM); S. pyogens 77A: 0.002 (1a), 0.004 (IPM), 0.002 (MPM); S. aureus 6538P: 0.031 (1a), 0.016 (IPM), 0.13 (MPM); S. aureus giogio: 0.016 (1a), 0.008 (IPM), 0.13 (MPM); S. aureus 77: 0.25 (1a), 0.13 (IPM), 2 (MPM); S. aureus 241: 8 (1a), 8 (IPM), 32 (MPM); S. pneumoniae PG-R PN01: 0.25 (1a), 0.25 (IPM), 0.25 (MPM); K. pneumoniae 2011E: 0.063 (1a), 0.13 (IPM), 0.031 (MPM); M. catarrhalis 25240: ≤0.008 (1a), ≤0.008 (IPM), ≤0.008 (MPM).