Phenytoin-induced toxic cholestatic hepatitis in a patient with skin lesions: Case report

Southern Medical Journal

Volumn 96, Issue 2, 2003, Pages 201-203

  Altuntaş, Yüksel ^a,b   Öztürk, Bülent ^a   Erdem, Levent ^a   Günes, Gürsel ^a   Karul, Sema ^a   Uçak, Sema ^a   Şengül, Ahmet ^a  

^a Sisli Etfal Research and Teaching Hospital   (Turkey)

^b Haznedar Mah   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; LIVER ENZYME; PHENYTOIN;

ADULT; ARTICLE; CASE REPORT; CHOLESTATIC HEPATITIS; DOSE RESPONSE; DRUG HYPERSENSITIVITY; EOSINOPHILIA; ERYTHEMA MULTIFORME; EXFOLIATIVE DERMATITIS; FEMALE; FEVER; HEPATOMEGALY; HUMAN; LEUKOCYTOSIS; LIVER BIOPSY; LIVER FUNCTION TEST; LIVER INJURY; LIVER TOXICITY; LYMPHADENOPATHY; LYMPHOCYTOSIS; RASH; SKIN DEFECT;

ANTICONVULSANTS; CHOLESTASIS; DERMATITIS, EXFOLIATIVE; FEMALE; HEPATITIS, TOXIC; HUMANS; MIDDLE AGED; PHENYTOIN; SEIZURES;

EID: 0037328142     PISSN: 00384348     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.SMJ.0000051269.23361.4A     Document Type: Article

References (15)

1. Gungor E, Alli N, Comcuoglu S, Comcuoglu C. Phenytoin hypersensitivity syndrome. Neurol Sci 2001;22:261-265.
2. de la Serna Higuera C, Gil Grande LA, Barcena Marugan R. Toxic cholestatic hepatitis due to phenytoin [in Spanish]. Gastroenterol Hepatol 1995;18:471-473.
3. Prosser TR, Lander RD. Phenytoin-induced hypersensitivity reactions. Clin Pharm 1987;6:728-734.
4. Mullick FG, Ishak KG. Hepatic injury associated with diphenylhydantoin therapy: A clinicopathologic study of 20 cases. Am J Clin Pathol 1980;74:442-452.
5. Roberts EA, Spielberg SP, Goldbach M, Phillips MJ. Phenobarbital hepatotoxicity in an 8-month-old infant. J Hepatol 1990; 10:235-239.
6. Kahn HD, Faguet GB, Agee JF, Middleton HM III. Drug-induced liver injury: In vitro demonstration of hypersensitivity to both phenytoin and phenobarbital. Arch Intern Med 1984;144:1677-1679.
7. Fonseca JC, Azulay DR, Rozembau I, Azulay RD. Hypersensitivity syndrome caused by phenytoin and phenobarbital [in Portuguese]. Med Cutan Ibero Lat Am 1984; 12:187-192.
8. Lee TJ, Carney CN, Lapis JL, Higgins T, Fallon HJ. Diphenylhydantoin-induced hepatic necrosis: A case study. Gastroenterology 1976;70:422-424.
9. Conger LA Jr, Grabski WJ. Dilantin hypersensitivity reaction. Cutis 1996;57:223-226.
10. Carro JA, Senior J, Rubio CE, Torres EA. Phenytoin induced fatal hepatic injury. Bol Asoc Med P R 1989;81:359-360.
11. Campbell CB, McGuffie C, Weedon AP, Powell LW. Cholestatic liver disease associated with diphenylhydantoin therapy: Possible pathogenic importance of altered bile salt metabolism. Am J Dig Dis 1977;22:255-262.
12. Spielberg SP, Gordon GB, Blake DA, Goldstein DA, Herlong HF. Predisposition to phenytoin hepatotoxicity assessed in vitro. N Engl J Med 1981;305:722-727.
13. Larrey D, Pageaux GP. Genetic predisposition to drug-induced hepatotoxicity. J Hepatol 1997;26(Suppl 2):12-21.
14. Gram L, Bentsen KD. Hepatic toxicity of antiepileptic drugs: A review. Acta Neurol Scand Suppl 1983;97:81-90.
15. Sherertz EF, Jegasothy BV, Lazarus GS. Phenytoin hypersensitivity reaction presenting with toxic epidermal necrolysis and severe hepatitis: Report of a patient treated with corticosteroid "pulse therapy." J Am Acad Dermatol 1985;12:178-181.