First-trimester maternal serum PAPP-A, SP1 and M-CSF levels in normal and trisomic twin pregnancies

Prenatal Diagnosis

Volumn 23, Issue 2, 2003, Pages 157-162

  Bersinger, N A ^a   Noble, P ^b   Nicolaides, K H ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

First trimester biochemical trisomy screening; PAPP A; Twin pregnancy

Indexed keywords

COLONY STIMULATING FACTOR 1; PREGNANCY ASSOCIATED PLASMA PROTEIN A; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DECIDUA; FETUS; FIRST TRIMESTER PREGNANCY; GESTATIONAL AGE; HUMAN; IMMUNOASSAY; PLACENTA; PRENATAL DIAGNOSIS; PRENATAL SCREENING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SERUM; TRISOMY 13; TRISOMY 18; TRISOMY 21; TWIN PREGNANCY;

ADULT; FEMALE; GENETIC SCREENING; HUMANS; IMMUNOASSAY; KARYOTYPING; MACROPHAGE COLONY-STIMULATING FACTOR; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PREGNANCY, MULTIPLE; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; PREGNANCY-SPECIFIC BETA 1-GLYCOPROTEINS; RETROSPECTIVE STUDIES; TRISOMY; TWINS;

EID: 0037327685     PISSN: 01973851     EISSN: None     Source Type: Journal    
DOI: 10.1002/pd.547     Document Type: Article

References (26)

1. Aitken DA, McKinnon D, Crossley JA, et al. 1994. Changes in the maternal serum concentrations of PAPP-A and SP1 in Down's syndrome pregnancies between the first and second trimesters. J Med Genet 31: 170.
2. Bersinger NA, Brizot ML, Johnson A, et al. 1994. First trimester maternal serum pregnancy-associated plasma protein A and pregnancy-specific β1-glycoprotein in fetal trisomies. Brit J Obstet Gynaecol 101: 970-974.
3. Bersinger NA, Marguerat P, Pescia G, Schneider H. 1995a. Pregnancy-associated plasma protein A (PAPP-A): measurement by highly sensitive and specific enzyme immunoassay, importance of first-trimester serum determinations, and stability studies. Reprod Fertil Dev 7: 1419-1423.
4. Bersinger NA, Zakher A, Huber U, Pescia G, Schneider H. 1995b. A sensitive enzyme immunoassay for pregnancy-associated plasma protein A (PAPP-A): a possible first trimester method of screening for Down syndrome and other trisomies. Arch Gynecol Obstet 256: 185-192.
5. Bersinger NA, Brandenberger AW, Birkhäuser MH. 1995c. Endometrial and placental protein markers and ovarian steroids in serum during in-vitro fertilisation cycles. Hum Reprod 10: 2149-2154.
6. Bersinger NA, Altermatt HJ, Birkhäuser MH, et al. 1997. Non-placental production of pregnancy-associated plasma protein A (PAPP-A): old and new evidence. Early Pregnancy Biol Med 3: 96-101.
7. Bersinger NA, Leporrier N, Herrou M, Leymarie P. 1999. Maternal serum pregnancy-associated plasma protein A (PAPP-A) but not pregnancy-specific β1-glycoprotein (SP1) is a useful second-trimester marker for fetal trisomy 18. Prenat Diagn 19: 537-541.
8. Bischof P. 1984. Placental proteins. Contrib Gynecol Obstet 12: 6-73.
9. Brambati B, Tului L, Bonacchi I, Shrimanker K, Suzuki Y, Grudzinskas JG. 1994. Serum PAPP-A and free β1-hCG are first-trimester screening markers for Down syndrome. Prenat Diagn 14: 1043-1047.
10. Brizot ML, Bersinger NA, Xydias G, Snijders RJ, Nicolaides KH. 1995. Maternal serum SP1 and fetal chromosomal abnormalities at 10-13 weeks' gestation. Early Hum Dev 43: 31-36.
11. Cuckle H, Lilford RJ, Teisner B, Holding S, Chard T, Grudzinskas JG. 1992. Pregnancy associated plasma protein A in Down's syndrome. Brit Med J 305: 425.
12. Folkersen J, Grudzinskas JG, Hindersson P, Teisner B, Westergaard JG. 1981. Pregnancy-associated plasma protein A: circulating levels during normal pregnancy. Am J Obstet Gynecol 139: 910-914.
13. Hayashi M, Numaguchi M, Watabe H, Yaoi Y. 1996. High blood levels of macrophage colony-stimulating factor in preeclampsia. Blood 88: 4426-4428.
14. Katano K, Matsumoto Y, Ogasawara M, et al. 1997. Low serum MCSF levels are associated with unexplained recurrent abortion. Am J Reprod Immunol 38: 1-5.
15. Knight GJ, Palomaki GE, Haddow JE, Miller W, Bersinger NA, Schneider H. 1993. Pregnancy-associated plasma protein A as a marker for Down syndrome in the second trimester of pregnancy. Prenat Diagn 13: 222, 223.
16. Lin TM, Halbert SP, Kiefer D, Spellacy WN, Gall S. 1974. Characterisation of four human pregnancy-associated plasma proteins. Am J Obstet Gynecol 118: 223-226.
17. Muller F, Cuckle H, Teisner B, Grudinskas JG. 1993. Serum PAPP-A levels are depressed in women with fetal Down syndrome in early pregnancy. Prenat Diagn 13: 633-636.
18. Niemimaa M, Suonpää M, Heinonen S, Seppää M, Bloigu R, Ryynänen M. 2002. Maternal serum human chorionic gonadotrophin and pregnancy-associated plasma protein A in twin pregnancies in the first trimester. Prenat Diagn 22: 183-185.
19. Noble PL, Snijders RJ, Abraha HD, Sherwood RA, Nicolaides KH. 1997. Maternal serum free β-hCG at 10 to 14 weeks of gestation in trisomic twin pregnancies. Brit J Obstet Gynaecol 104: 741-743.
20. Saito S, Saito M, Motoyoshi K, Ichijo M. 1991. Enhancing effects of human macrophage colony-stimulating factor on the secretion of human chorionic gonadotrophin by human chorionic villous cells and tPA30-1 cells. Biochem Biophys Res Commun 178: 1099-1104.
21. Spencer K. 2000. Screening for trisomy 21 in twin pregnancies in the first trimester using free β-HCG and PAPP-A, combined with fetal nuchal translucency. Prenat Diagn 20: 91-95.
22. Tatarinov YS, Masyukevich VN. 1970. Immunological identification of a new beta1-globulin in the blood serum of pregnant women. Bull Exp Biol Med USSR 69: 66-68.
23. Towler CM, Home CH, Jandial V, Campbell DM, MacGillivray I. 1976. Plasma levels of pregnancy-specific β1-glycoprotein in normal pregnancy. Brit J Obstet Gynaecol 83: 775-779.
24. Tsakonas DP, Nicolaides KH, Tsakona CP, Worman CP, Goldstone AH. 1995. Changes in maternal plasma macrophage-colony stimulating factor levels during normal pregnancy. Clin Lab Haematol 17: 57-59.
25. Wald NJ, Hackshaw AK. 2000. Advances in antenatal screening for Down syndrome. Bailliè's Clin Obstet Gynaecol 14: 563-580.
26. Wheeler DM, Sinosich MJ. 1998. Prenatal screening in the first trimester of pregnancy. Prenat Diagn 18: 537-543.