Intra-individual comparison of the cutaneous safety and efficacy of calcitriol 3 μg g-1 ointment and calcipotriol 50 μg g-1 ointment on chronic plaque psoriasis localized in facial, hairline, retroauricular or flexural areas

British Journal of Dermatology

Volumn 148, Issue 2, 2003, Pages 326-333

  Ortonne, J P ^a   Humbert, P ^b   Nicolas, J F ^c   Tsankov, N ^d   Tonev, S D ^e   Janin, A ^f   Czernielewski, J ^f   Lahfa, M ^g   Dubertret, Louis ^g  

^a CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

^b HÔPITAL SAINT JACQUES   (France)

^c CENTRE HOSPITALIER LYON SUD   (France)

^d UNIVERSITY HOSPITAL ALEXANDROVSKA   (Bulgaria)

^e MILITARY MEDICAL ACADEMY   (Bulgaria)

^f Galderma R and D   (France)

^g SAINT LOUIS HOSPITAL   (France)

Author keywords

Calcipotriol; Calcitriol; Chronic plaque psoriasis; Sensitive skin areas; Vitamin D

Indexed keywords

CALCIPOTRIOL; CALCITRIOL;

ADULT; AGED; ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONTACT DERMATITIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FACE; FEMALE; HAIR; HUMAN; IRRITANT DERMATITIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; PSORIASIS; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SKIN ALLERGY; SKIN BURNING SENSATION; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AXILLA; CALCITRIOL; DERMATOLOGIC AGENTS; DOUBLE-BLIND METHOD; DRUG TOLERANCE; EAR, EXTERNAL; EDEMA; ERYTHEMA; FACIAL DERMATOSES; FEMALE; HUMANS; MALE; MIDDLE AGED; OINTMENTS; PATIENT SATISFACTION; PSORIASIS; TREATMENT OUTCOME;

EID: 0037325836     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.2003.05228.x     Document Type: Article

References (19)

1. Ortonne JP. Recent developments in the understanding of the pathogenesis of psoriasis. Br J Dermatol 1999; 140 (Suppl. 54): 1-7.
2. Greaves M, Weinstein G. Treatment of psoriasis. N Engl J Med 1995; 332: 581-8.
3. Berth-Jones J. The emergence of vitamin D as a first-line treatment for psoriasis. J Dermatol Treat 1998; 9 (Suppl. 3): S13-18.
4. 3) treatment of psoriasis: an immunohistological evaluation. Acta Derm Venereol 1997; 77: 268-72.
5. Farber E, Bright R, Nall M. Psoriasis: a questionnaire survey of 2,144 patients. Arch Dermatol 1968; 98: 248-59.
6. Murdoch D, Clissold SP. Calcipotriol. A review of its pharmacological properties and therapeutic use in psoriasis vulgaris. Drugs 1992; 43: 415-29.
7. Barker JNWN, Griffiths cem, Poncet M et al. Systematic evaluation of calcitriol 3 μg/g ointment in subjects with chronic plaque psoriasis involving a variable body surface area. J Eur Acad Dermatol Venereol 2001; 15 (Suppl. 249): [Poster 24-48].
8. 3 (calcitriol) ointment in psoriasis. J Dermatol Treat 1992; 3: 177-80.
9. Queille-Roussel C, Duteil L, Parneix-Spake A et al. The safety of calcitriol 3 μg/g ointment. Evaluation of cutaneous contact sensitization, cumulative irritancy, photoallergic contact sensitization and phototoxicity. Eur J Dermatol 2001; 11: 219-24.
10. Langner A, Ashton P, van de Kerkhof PCM, Verjans H. A long-term multicentre assessment of the safety and tolerability of calcitriol ointment in the treatment of chronic plaque psoriasis. Br J Dermatol 1996; 135: 385-9.
11. Parneix-Spake A, Squire A, Arsonnaud S et al. Evaluation of the safety profile of calcitriol ointment in terms of cutaneous contact sensitization and irritancy. J Eur Acad Dermatol Venereol 2001; 15 (Suppl. 260): [Poster P19-57].
12. Queille-Roussel C, Poncet M, Rizova E, Pernin C. Cumulative irritancy potential of calcitriol ointment versus calcipotriol ointment and cream in healthy subjects. J Eur Acad Dermatol Venereol 2001; 15 (Suppl. 238): [Poster 24-6].
13. 3 metabolites and analogues in the treatment of scalp psoriasis. J Dermatol Treat 1998; 9 (Suppl. 3): S41-5.
14. Kragballe K. Vitamin D and derivatives. In: Psoriasis (Dubertret L. ed.). Brescia: ISED. 1994; 123-34.
15. de Arruda L, de Moraes A. The impact of psoriasis on quality of life. Br J Dermatol 2001; 144 (Suppl. 58): 33-6.
16. Krueger G, Koo J, Lebwohl M et al. The impact of psoriasis on quality of life: results of a 1998 National Psoriasis Foundation patient-membership survey. Arch Dermatol 2001; 137: 280-4.
17. 3 analogue calcipotriol. Arch Dermatol 1989; 125: 1647-52.
18. Kragballe K, Gjertsen BT, De Hoop D et al. Double-blind, right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris. Lancet 1991; 337: 193-6.
19. van de Kerkhof PCM, de Hoop D. de Korte J, Kuipers MV. Scalp psoriasis, clinical presentations and therapeutic management. Dermatology 1998; 197: 326-34.