Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra

Psychiatry and Clinical Neurosciences

Volumn 57, Issue 1, 2003, Pages 97-104

  Tan, Xin ^a,b   Uchida, Sunao ^a   Matsuura, Masato ^b   Nishihara, Kyoko ^a   Kojima, Takuya ^b  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b NIHON UNIVERSITY   (Japan)

Author keywords

Benzodiazepines; Pharmacological potency; Sleep electroencephalogram; Spectral analysis

Indexed keywords

BENZODIAZEPINE; FLUNITRAZEPAM; HALOXAZOLAM; TRIAZOLAM;

ADULT; ARTICLE; BETA RHYTHM; CHRONOPHARMACOLOGY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG HALF LIFE; DRUG POTENCY; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAM; FOURIER TRANSFORMATION; FREQUENCY ANALYZER; HUMAN; MALE; NONREM SLEEP; POWER SPECTRUM; PSYCHOPHARMACOLOGY; REM SLEEP; SLEEP PARAMETERS; SLEEP TIME; SLEEP WAKING CYCLE; SPECTROSCOPY; THETA RHYTHM;

ADULT; ANTI-ANXIETY AGENTS; BENZODIAZEPINES; BETA RHYTHM; DOUBLE-BLIND METHOD; ELECTROCARDIOGRAPHY; ELECTROENCEPHALOGRAPHY; ELECTROOCULOGRAPHY; FLUNITRAZEPAM; HUMANS; MALE; SLEEP STAGES; TRIAZOLAM;

EID: 0037324429     PISSN: 13231316     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1819.2003.01085.x     Document Type: Article

References (24)

1. Duka T, Holt V, Herz A. Occupation by benzodiazepines and correlation with pharmaological effect. Brain Res. 1979; 179: 147-156.
2. Greenblatt DJ, Miller LG, Shader BI. Neurochemical and pharmacokinetic correlates of the clinical ation of benzodiazepine hypnotic drugs. Am. J. Med. 1990; 88: 18S-24S.
3. Greenblatt DJ. Benzodiazepine hypnotics: Sorting the pharmacokinetic facts. J. Clin. Psychiatry 1991; 52 (9 Suppl.): 4-10.
4. Breimer DD. Pharmacokinetics and metabolism of various benzodiazepines used as hypnotics. Br. J. Clin. Pharmacol. 1979; 8: 7S-13S.
5. Roth T, Roehrs TA. Issues in the use of benzodiazepine therapy. J. Clin. Psychiatry 1992; 53: 14-18.
6. Hommer D, Weingartner H, Breier A. Disociation of benzodiazepine induced amnesia from sedation by flumazenil pretreatment. Psychopharmacology 1993; 112: 455-460.
7. Mendelson WB. Clinical distinctions between long-acting and short-acting benzodiazepines. J. Clin. Psychiatry 1992; 53: 4-7.
8. Muraoka M, Tada K, Nogami Y, Ishikawa K, Nagoya T. Residual effects of repeated administration of triazolam and nitrazepam in healthy volunteers. Neuropsychobiology 1992; 25: 134-139.
9. Tazaki T, Tada K, Nogami Y, Takemura N, Ishikawa K. Effects of butoctamide hydrogen succinate and nitrazepam on psychomotor function and EEG in healthy volunteers. Psychopharmacology (Berl) 1989; 97: 370-375.
10. Misaki K, Nakagawa H, Koshino Y et al. Effect of flunitrazepam on sleep and memory. Psychiatry Clin. Neurosci. 1998; 52: 327-332.
11. Uchida S, Okudaira N, Nishihara K, Iguchi Y. Flunitrazepam effects on human sleep EEG spectra: Differences in NREM, REM and individual responses. Life Sci. 1996; 58: PL199-205.
12. Uchida S, Okudaira N, Nishihara K, Iguchi Y, Xin T. Flunitrazepam effects on human sleep EEG spectra II. Sigma and beta alterations during NREM sleep. Life Sci. 1996; 59: PL117-120.
13. Tan X, Uchida S, Matsuura M, Nishihara K, Iguchi Y, Kojima T. Benzodiazepine effects on human sleep EEG spectra: a comparison of triazolam and flunitrazepam. Life Sci. 1998; 63: 675-684.
14. Rechtschaffen A, Kales A. A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Washington, DC: Public Health Service U.S. Government Printing Office, 1968.
15. Feinberg I. Changes in sleep cycle patterns with age. J. Psychiat. Res. 1974; 10: 283-306.
16. Itil TM, Saletu B, Marasa J. Determination of drug-induced changes in sleep qulity based on digital computer 'sleep prints'. Pharmakopsychiatr. Neuropsychopharmakol. 1974; 7: 265-280.
17. Borbely AA, Mattmann P, Loepfe M, Strauch I, Lehmann D. Effect of benzodiazepine hypnotics on all-night sleep EEG spectra. Hum. Neurobiol. 1985; 4: 189-194.
18. Gevins AS, Stone RK, Ragsdale SD. Differentiating the effects of benzodiazepines on NREM sleep EEG spectra. Neuropsychobiology 1988; 19: 108-115.
19. Johnson LC, Spinweber CL. Effects of short-acting benzodiazepine on brain electrical activity during sleep. Electroenceph. Clin. Neurophysiol. 1981; 52: 89-97.
20. Hirshkowitz M, Thornby JI, Karacan I. Sleep spindles: Pharmacological effects in humans. Sleep 1982; 5: 85-94.
21. Uchida S, Maloney T, Feinberg I. Sigma (12-16 Hz) and beta (20-28 Hz) EEG discriminate NREM and REM sleep. Brain Res. 1994; 659: 243-248.
22. Steriade M, Domich L, Oakson G. The deafferented reticular thalamic nucleus generates spindle rhythmicity. J. Neurophysiol. 1987; 57: 260-273.
23. Kobayashi T, Kiuchi Y, Shimizu H, Takeuchi J, Ogata H, Toru M. Studies on benzodiazepine recepto in human post-mortem brain. Ann. Rep Pharmacopsychiat. Res. Found. 1989; 20: 113-120.
24. Saletu B, Anderer P, Brandstatter N et al. Insomnia in generalized anxiety disorder: polysomnographic, psychometric and clincal investigations before, during and after therapy with a long- versus a short-half-life benzodiazepine (quazepam versus triazolam). Neuropyschobiology 1994; 29: 69-90.