Significant enhancement of gastric mucin content after rabeprazole administration: Its potential clinical significance in acid-related disorders

Digestive Diseases and Sciences

Volumn 48, Issue 2, 2003, Pages 322-328

  Skoczylas, T ^a   Sarosiek, I ^a   Sostarich, S ^a   McElhinney, C ^a   Durham, S ^a   Sarosiek, Jerzy ^a,b  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Gastric mucin; Mucus; Rabeprazole; Viscosity

Indexed keywords

PENTAGASTRIN; PLACEBO; RABEPRAZOLE; STOMACH MUCIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MECHANISM; DRUG UTILIZATION; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MUCUS SECRETION; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STIMULATION; STOMACH ACID; STOMACH JUICE; STOMACH MUCOSA; STOMACH MUCUS; STOMACH PH; STOMACH PROTECTION; VISCOSITY;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ADULT; ANALYSIS OF VARIANCE; BENZIMIDAZOLES; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; GASTRIC ACIDITY DETERMINATION; GASTRIC MUCIN; GASTRIC MUCOSA; HUMANS; MALE; MIDDLE AGED; MUCUS; OMEPRAZOLE; PROBABILITY; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY;

EID: 0037324026     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021983611768     Document Type: Article

References (28)

1. Sarosiek J, Marshall BJ, Peura DA, Hoffman S, Feng T, McCallum RW: Gastroduodenal mucus gel thickness in patients with Helicobacter pylori: a method for assessment of biopsy specimens. Am J Gastroenterol 86:729-734, 1991
2. Slomiany BL, Sarosiek J, Slomiany A: Gastric mucus and the mucosal barrier. Dig Dis 5:125-145, 1987
3. Sarosiek J, McCallum RW: The evolving appreciation of the role of esophageal mucosal protection in the pathophysiology of gastroesophageal reflux disease. J Pract Gastroenterol 18:20J-20Q, 1994
4. Allen A: Structure and function of gastrointestinal mucus. In Physiology of the Gastrointestinal Tract. LR Johnson (ed.) Raven Press: New York, 1981, pp. 617-639
5. Allen A, Flemstrom G, Garner A, Kivilaakso E: Gastroduodenal mucosal protection. Physiol Rev 73:823-857, 1993
6. Peterson WL, Barnett CC, Evans DJ Jr, Feldman M, Carmody T. Richardson C. Walsh J, Graham DY: Acid secretion and serum gastrin in normal subjects and patients with duodenal ulcer: the role of Helicobacter pylori [see comments]. Am J Gastroenterol 88:2038-2043, 1993
7. Hunt RH: pH and Hp - gastric acid secretion and Helicobacter pylori: implications for ulcer healing and eradication of the organism [editorial; comment]. Am J Gastroenterol 88:481-483, 1993
8. Feldman M, Barnett C: Fasting gastric pH and its relationship to tree hypochlorhydria in humans. Dig Dis Sci 36:866-869, 1991
9. Huang JQ, Hunt RH: pH, healing rate and symptom relief in acid-related diseases. Yale J Biol Med 69:159-174, 1996
10. Wormsley KG: Campylobacter pylori and ulcer disease - a causal connection. Scand J Gastroenterol Suppl 160:53-58, 1989
11. Sarosiek J, Mizuta K, Slomiany A, Slomiany BL: Effect of acetylsalicylic acid on gastric mucin viscosity, permeability to hydrogen ion and susceptibility to pepsin. Biochem Pharmacol 35:4291-4295, 1986
12. Sarosiek J, Slomiany A, Slomiany BL: Retardation of hydrogen ion diffusion by gastric mucus constituents: Effect of proteolysis. Biochem Biophys Res Commun 113:1053-1060, 1983
13. Sarosiek J, Slomiany A, Slomiany BL: Evidence for weakening of gastric mucus integrity by Campylobacter pylori. Scand J Gastroenterol 23:585-590, 1988
14. Sarosiek J, Feng T, McCallum RW: The interrelationship between salivary epidermal growth factor and the functional integrity of the esophageal mucosal barrier in the rat. Am J Med Sci 302:359-363, 1991
15. Bilski J, Sarosiek J, Murty VLN, Aono M, Moriga M, Slomiany A, Slomiany BL: Enhancament of the lipid content and physical properties of gastric mucus by geranylgeranylacetone. Biochem Pharmacol 36:4059-4065, 1987
16. +-ATPase. Annu Rev Pharmacol Toxicol 35:277-305, 1995
17. Takiuchi H, Asada S, Umegaki E, Tahashi Y, Ohshiba S: Effects of proton pump inhibitors: omeprazole, lansoprazole, and E-3810 on the gastric mucin. 1404P (abstract), 1994
18. Namiot Z, Sarosiek J, Rourk RM, McCallum RW: Human esophageal secretion: Mucosal response to luminal acid and pepsin. Gastroenterology 106:973-981, 1994
19. Zalewsky CA, Moody FG: Mechanisms of mucus release in exposed canine gastric mucosa. Gastroenterology 79:719-730, 1979
20. Sarosiek J, Slomiany A, Takagi T, Slomiany BL: Hydrogen ion diffusion in dog gastric mucus glycoprotein: Effect of associated lipids and covalently bound fatty acids. Biochem Biophys Res Commun 118:523-531, 1984
21. Namiot Z, Sarosiek J, Marcinkiewicz M, Edmunds MC, McCallum RW: Declined human esophageal mucin secretion in patients with severe reflux esophagitis. Dig Dis Sci 39:2523-2529, 1994
22. 2 in residual gastric juice reflects endoscopic damage to the gastric mucosa after naproxen sodium administration. Am J Gastroenterol 91:873-878, 1996
23. Marcinkiewicz M, Sarosiek J, Peura DA: The relationship between the content of gastric mucus protective components in gastric juice and endoscopic damage to the gastric mucosa after naproxen sodium administration. Am J Gastroenterol 91:360-365, 1996
24. Slomiany BL, Murty VLN, Sarosiek J, Piotrowski J. Slomiany A: Role of associated and covalently bound lipids in salivary mucin hydrophobicity: effect of proteolysis and disulphide bridge reduction. Biochem Biophys Res Commun 151:1046-1053, 1988
25. Hills BA, Butler BD, Lichtenberger LM: Gastric mucosal barrier: hydrophobic lining to the lumen of the stomach. Am J Physiol 244:G561-G568, 1983
26. Go MF, Lew GM, Lichtenberger LM, Genta RM, Graham DY: Gastric mucosal hydrophobicity and Helicobacter pylori: response to antimicrobial therapy. Am J Gastroenterol 88:1362-1365, 1993
27. Sarosiek J, Namiot Z, Marshall BJ, Peura D, Guerrant RL, Harlow D, McCallum RW: Breakdown of the mucus layer by H. pylori. In Helicobacter pylori: Basic Mechanisms to Clinical Cure. RH Hunt, GNJ Tytgat, (eds.) Kluwer Academic, Dordrecht, 1994, pp. 123-138
28. DeRosa J, Marcinkiewicz M, Sarosiek J, Edmunds MC, McCallum RW: Modulatory impact of acid and pepsin on esophageal hydrophobicity in human. Am J Gastroenterol 90:2020-2024, 1995